Importance of maternal and cord blood viremia in pregnant women with chronic hepatitis B virus infection

[Guest guest]

http://www.ejinme.com/article/PIIS0953620510002414/abstract?rss=yes

European Journal of Internal Medicine

Volume 22, Issue 2 , Pages 182-186, April 2011

Importance of maternal and cord blood viremia in pregnant women with chronic

hepatitis B virus infection¡î

Ioannis S. Elefsiniotis

Affiliations

University Department of Internal Medicine-Hepatology Unit, ¡°Elena Venizelou¡±

Hospital, Athens, Greece

Corresponding author. Carchidonos 9, A. Glyfada, 16562, Athens, Greece.

, Konstantinos Tsoumakas

Affiliations

Department of Pediatrics, Faculty of Nursing, University of Athens, Greece

, Miltos Papadakis

Affiliations

University Department of Obstetrics and Gynecology, ¡°andra¡± Hospital,

Athens, Greece

, Vlachos

Affiliations

University Department of Obstetrics and Gynecology, ¡°andra¡± Hospital,

Athens, Greece

, Saroglou

Affiliations

University Department of Obstetrics and Gynecology, ¡°andra¡± Hospital,

Athens, Greece

, Aristidis Antsaklis

Affiliations

University Department of Obstetrics and Gynecology, ¡°andra¡± Hospital,

Athens, Greece

Received 7 September 2010; received in revised form 30 November 2010; accepted 7

December 2010. published online 10 January 2011.

Abstract

Background/aim

The spontaneous preterm birth (SPB) rates in a group of HBeAg-negative chronic

HBV infected pregnant women without several known risk factors for preterm

delivery as well as the mother to infant HBV transmission rates was evaluated.

Moreover the role of maternal data during perinatal period as well as the role

of HBsAg and/or HBV-DNA presence in cord blood in respect to preterm labour and

vertical transmission of the infection was examined.

Methods

138 consecutive chronic HBV infected pregnant women were haematologically,

serologically and virologically evaluated during the perinatal period. 102 women

were finally evaluated and fifteen of them (14.7%) exhibited SPB. Overall, 44

infants who had completed the proposed vaccination schedule were evaluated at

month 12 of their life.

Results

A significant association between SPB and HBV-DNA presence in cord blood was

observed (p=0.007). HBV-DNA positivity in cord blood was significantly

associated with maternal HBV-DNA levels (p=0.002). The relative risk of HBV-DNA

presence in cord blood was 6.43 times higher among women with serum

HBV-DNA¡Ý10.000copies/ml and lymphocyte count<1500 compared to those with all

the other combinations of both parameters (p=0.001). All infants evaluated at

month 12 were HBsAg-negative and exhibited undetectable HBV-DNA levels.

Conclusion

The presence of HBV-DNA in cord blood is significantly associated with SPB in

chronic HBV infected pregnant women. Maternal or cord blood viremia does not

pose an additional risk factor for vertical transmission of HBV infection, in

passive¨Cactive immunoprotected infants from HBeAg-negative chronic HBV infected

mothers.

[Guest guest]

http://www.ejinme.com/article/PIIS0953620510002414/abstract?rss=yes

European Journal of Internal Medicine

Volume 22, Issue 2 , Pages 182-186, April 2011

Importance of maternal and cord blood viremia in pregnant women with chronic

hepatitis B virus infection¡î

Ioannis S. Elefsiniotis

Affiliations

University Department of Internal Medicine-Hepatology Unit, ¡°Elena Venizelou¡±

Hospital, Athens, Greece

Corresponding author. Carchidonos 9, A. Glyfada, 16562, Athens, Greece.

, Konstantinos Tsoumakas

Affiliations

Department of Pediatrics, Faculty of Nursing, University of Athens, Greece

, Miltos Papadakis

Affiliations

University Department of Obstetrics and Gynecology, ¡°andra¡± Hospital,

Athens, Greece

, Vlachos

Affiliations

University Department of Obstetrics and Gynecology, ¡°andra¡± Hospital,

Athens, Greece

, Saroglou

Affiliations

University Department of Obstetrics and Gynecology, ¡°andra¡± Hospital,

Athens, Greece

, Aristidis Antsaklis

Affiliations

University Department of Obstetrics and Gynecology, ¡°andra¡± Hospital,

Athens, Greece

Received 7 September 2010; received in revised form 30 November 2010; accepted 7

December 2010. published online 10 January 2011.

Abstract

Background/aim

The spontaneous preterm birth (SPB) rates in a group of HBeAg-negative chronic

HBV infected pregnant women without several known risk factors for preterm

delivery as well as the mother to infant HBV transmission rates was evaluated.

Moreover the role of maternal data during perinatal period as well as the role

of HBsAg and/or HBV-DNA presence in cord blood in respect to preterm labour and

vertical transmission of the infection was examined.

Methods

138 consecutive chronic HBV infected pregnant women were haematologically,

serologically and virologically evaluated during the perinatal period. 102 women

were finally evaluated and fifteen of them (14.7%) exhibited SPB. Overall, 44

infants who had completed the proposed vaccination schedule were evaluated at

month 12 of their life.

Results

A significant association between SPB and HBV-DNA presence in cord blood was

observed (p=0.007). HBV-DNA positivity in cord blood was significantly

associated with maternal HBV-DNA levels (p=0.002). The relative risk of HBV-DNA

presence in cord blood was 6.43 times higher among women with serum

HBV-DNA¡Ý10.000copies/ml and lymphocyte count<1500 compared to those with all

the other combinations of both parameters (p=0.001). All infants evaluated at

month 12 were HBsAg-negative and exhibited undetectable HBV-DNA levels.

Conclusion

The presence of HBV-DNA in cord blood is significantly associated with SPB in

chronic HBV infected pregnant women. Maternal or cord blood viremia does not

pose an additional risk factor for vertical transmission of HBV infection, in

passive¨Cactive immunoprotected infants from HBeAg-negative chronic HBV infected

mothers.