Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: Comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores

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J Hepatol. 2008 Oct 26. [Epub ahead of print]

Early detection in routine clinical practice of cirrhosis and oesophageal

varices in chronic hepatitis C: Comparison of transient elastography (FibroScan)

with standard laboratory tests and non-invasive scores.

Castéra L, Bail BL, Roudot-Thoraval F, Bernard PH, Foucher J, Merrouche W,

Couzigou P, de Lédinghen V.

Service d'Hépato-Gastroentérologie, Hôpital Haut-Lévêque, Centre Hospitalier

Universitaire (CHU) de Bordeaux, Pessac, France; Service

d'Hépato-Gastroentérologie, Hôpital Saint-André, CHU Bordeaux, Bordeaux, France.

BACKGROUND/AIMS: To assess prospectively the accuracy of transient elastography

(TE, FibroScan) for the detection of cirrhosis and oesophageal varices (OV) in

chronic hepatitis C (CHC), as compared with currently available non-invasive

methods (AST/ALT ratio (AAR), APRI, prothrombin index (PI), platelet count (PC),

FibroTest (FT) and Lok index). METHODS: All tests were performed the day of

liver biopsy (LB), taken as reference, in 298 consecutive CHC patients

(cirrhosis: 70; Child-Pugh A: 70; OV: 25). RESULTS: TE had the best diagnostic

accuracy for detection of cirrhosis (AUROCs: TE 0.96 vs. FT 0.82, Lok and APRI

0.80, PC 0.79, PI 0.73, AAR 0.61, respectively; p

[Guest guest]

J Hepatol. 2008 Oct 26. [Epub ahead of print]

Early detection in routine clinical practice of cirrhosis and oesophageal

varices in chronic hepatitis C: Comparison of transient elastography (FibroScan)

with standard laboratory tests and non-invasive scores.

Castéra L, Bail BL, Roudot-Thoraval F, Bernard PH, Foucher J, Merrouche W,

Couzigou P, de Lédinghen V.

Service d'Hépato-Gastroentérologie, Hôpital Haut-Lévêque, Centre Hospitalier

Universitaire (CHU) de Bordeaux, Pessac, France; Service

d'Hépato-Gastroentérologie, Hôpital Saint-André, CHU Bordeaux, Bordeaux, France.

BACKGROUND/AIMS: To assess prospectively the accuracy of transient elastography

(TE, FibroScan) for the detection of cirrhosis and oesophageal varices (OV) in

chronic hepatitis C (CHC), as compared with currently available non-invasive

methods (AST/ALT ratio (AAR), APRI, prothrombin index (PI), platelet count (PC),

FibroTest (FT) and Lok index). METHODS: All tests were performed the day of

liver biopsy (LB), taken as reference, in 298 consecutive CHC patients

(cirrhosis: 70; Child-Pugh A: 70; OV: 25). RESULTS: TE had the best diagnostic

accuracy for detection of cirrhosis (AUROCs: TE 0.96 vs. FT 0.82, Lok and APRI

0.80, PC 0.79, PI 0.73, AAR 0.61, respectively; p