PBMC: HCV - CD5+ B cells is associated with mild disease in chronic HCV

[Guest guest]

J Hepatol 2000 Jan;32(1):121-5

Expansion of peripheral blood CD5+ B cells is associated with mild disease

in chronic hepatitis C virus infection.

Curry MP, Golden-Mason L, Nolan N, Parfrey NA, Hegarty JE, O'Farrelly C

The Liver Unit, St 's Hospital, Dublin, Ireland.

BACKGROUND/AIMS:

Hepatitis C virus (HCV) infection is associated with the development of

chronic liver disease and extra-hepatic manifestations, which include

autoantibody production, immune-mediated diseases such as

cryoglobulinaemia and B-cell lymphoproliferation.

Recent identification of intra-hepatic clonal B cells capable of rheumatoid

factor production, selective infection of B cells over T cells and of an HCV

receptor on B lymphocytes strongly supports a central role for these cells

in the immune response to HCV infection.

In particular, CD5+ B cells which are capable of producing natural

antibodies with autoreactive specificities are likely to be important in the

development of HCV-associated autoimmunity and lymphoproliferation.

METHODS: We have investigated the presence of CD5+ B cells in a unique

cohort of HCV-infected women who were infected with a single inoculum of HCV

genotype 1b following immunisation with contaminated anti-D immunoglobulin

in 1977.

RESULTS: CD5+ B cells are significantly increased in chronic HCV infection

(37.66+/-1.92%) as compared with those with resolved infection

(25.33+/-1.90%). High levels of CD5+ B cells were associated with the

production of rheumatoid factor. The number of peripheral blood CD5+ B cells

correlated negatively with histological activity index.

CONCLUSIONS:

The expansion of this B cell population in patients with active HCV

infection may give rise to immune-mediated sequelae associated with HCV

infection.

This expanded population of CD5+ B cells may protect against the development

of progressive liver disease.

PMID: 10673076, UI: 20135631

[Guest guest]

J Hepatol 2000 Jan;32(1):121-5

Expansion of peripheral blood CD5+ B cells is associated with mild disease

in chronic hepatitis C virus infection.

Curry MP, Golden-Mason L, Nolan N, Parfrey NA, Hegarty JE, O'Farrelly C

The Liver Unit, St 's Hospital, Dublin, Ireland.

BACKGROUND/AIMS:

Hepatitis C virus (HCV) infection is associated with the development of

chronic liver disease and extra-hepatic manifestations, which include

autoantibody production, immune-mediated diseases such as

cryoglobulinaemia and B-cell lymphoproliferation.

Recent identification of intra-hepatic clonal B cells capable of rheumatoid

factor production, selective infection of B cells over T cells and of an HCV

receptor on B lymphocytes strongly supports a central role for these cells

in the immune response to HCV infection.

In particular, CD5+ B cells which are capable of producing natural

antibodies with autoreactive specificities are likely to be important in the

development of HCV-associated autoimmunity and lymphoproliferation.

METHODS: We have investigated the presence of CD5+ B cells in a unique

cohort of HCV-infected women who were infected with a single inoculum of HCV

genotype 1b following immunisation with contaminated anti-D immunoglobulin

in 1977.

RESULTS: CD5+ B cells are significantly increased in chronic HCV infection

(37.66+/-1.92%) as compared with those with resolved infection

(25.33+/-1.90%). High levels of CD5+ B cells were associated with the

production of rheumatoid factor. The number of peripheral blood CD5+ B cells

correlated negatively with histological activity index.

CONCLUSIONS:

The expansion of this B cell population in patients with active HCV

infection may give rise to immune-mediated sequelae associated with HCV

infection.

This expanded population of CD5+ B cells may protect against the development

of progressive liver disease.

PMID: 10673076, UI: 20135631