A comparison of four fibrosis indexes in chronic HCV: Development of new fibrosis-cirrhosis index (FCI)

April 22, 2011

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A comparison of four fibrosis indexes in chronic HCV: Development of new

fibrosis-cirrhosis index (FCI)

BMC Gastroenterology, 04/22/2011

Ahmad W et al. - The fibrosis-cirrhosis index (FCI) accurately predicted

fibrosis stages in Hepatitis C virus (HCV) infected patients and seems more

efficient than frequently used serum indexes.Methods

157 HCV infected patients who underwent liver biopsy.

In order to differentiate HCV fibrosis progression, readily available AAR, APRI,

FI and FIB-4 serum indexes were tested in the patients.

A new fibrosis-cirrhosis index (FCI) comprised of ALP, bilirubin, serum albumin

and platelet count. FCI = [(ALP x Bilirubin) / (Albumin x Platelet count)] was

derived.

Results

Already established serum indexes AAR, APRI, FI and FIB-4 were able to stage

liver fibrosis with correlation coefficient indexes 0.130, 0.444, 0.578 and

0.494, respectively.

The new fibrosis cirrhosis index FCI significantly correlated with the

histological fibrosis stages F0-F1, F2-F3 and F4 (r =0.818, p<0.05) with AUROCs

0.932 and 0.996, respectively.

The sensitivity and PPV of FCI at a cutoff value <0.130 for predicting fibrosis

stage F0-F1 was 81% and 82%, respectively with AUROC 0.932.

Corresponding value of FCI at a cutoff value [greater than or equal to]1.25 for

the prediction of cirrhosis was 86% and 100%.

April 22, 2011