Prophylactic analgesia before percutaneous liver biopsy: a clinical comparative study

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Source: Eur J Gastroenterol Hepatol | Posted 6 days ago

Prophylactic analgesia before percutaneous liver biopsy: a clinical comparative

study

Kramskay R, Tansky A, Eisenberg E, Veitsman E, Baruch Y

European Journal of Gastroenterology and Hepatology (Jun 2011)

INTRODUCTION: Liver biopsy remains the gold standard for the diagnosis and

staging of liver diseases. Despite being painful, analgesia before liver biopsy

is usually avoided due to the notion that pain is minor and due to the concern

of masking possible abdominal symptoms. Postbiopsy pain levels were previously

mapped for the purpose of analgesia planning. AIM: To compare pain and anxiety

levels between two prophylactic treatment regimens, a combination of sublingual

tramadol Hcl with oral lorazepam and oral diazepam only. PATIENTS AND METHODS:

One hundred and thirteen consecutive patients were selected to receive either

prophylactic analgesia with sublingual tramadol Hcl (50 mg) flashtabs and oral

lorazepam [(1 mg) analgesia group (AG), n=56] or oral diazepam (5 mg) alone

[nonAG (NAG), n=57]. Pain and anxiety levels were assessed using Visual Analogue

Scale (1-10) and State Anxiety Inventory, respectively, 30 min before, and 30

min and 6 h after the biopsy. RESULTS: The groups were comparable with respect

to baseline characteristics. Thirty minutes after the procedure, pain levels

were significantly lower in the AG (mean Visual Analogue Scale±standard error of

the mean, 1.8±0. 3; median=1) compared with the NAG (3.1±0.3, median=3;

P<0.005). Patients in the NAG (13.8%), reported high pain intensities (>7)

compared with the patients in the AG (3.6%; P=0.09). Six hours after the

procedure, pain intensity remained significantly lower in the AG compared with

the NAG (0.8±0.1 vs. 1.5±0.2; P<0.005). Anxiety levels were comparable.

CONCLUSION: Prophylactic combination of short-acting tramadol and lorazepam is

effective, safe, and can be used routinely before liver biopsy.

[Guest guest]

http://www.docguide.com/prophylactic-analgesia-percutaneous-liver-biopsy-clinica\

l-comparative-study?hash=04301bd4 & eid=21056 & alrhash=2e06a4-d460252966da8019c5213\

f6ae197892e

Source: Eur J Gastroenterol Hepatol | Posted 6 days ago

Prophylactic analgesia before percutaneous liver biopsy: a clinical comparative

study

Kramskay R, Tansky A, Eisenberg E, Veitsman E, Baruch Y

European Journal of Gastroenterology and Hepatology (Jun 2011)

INTRODUCTION: Liver biopsy remains the gold standard for the diagnosis and

staging of liver diseases. Despite being painful, analgesia before liver biopsy

is usually avoided due to the notion that pain is minor and due to the concern

of masking possible abdominal symptoms. Postbiopsy pain levels were previously

mapped for the purpose of analgesia planning. AIM: To compare pain and anxiety

levels between two prophylactic treatment regimens, a combination of sublingual

tramadol Hcl with oral lorazepam and oral diazepam only. PATIENTS AND METHODS:

One hundred and thirteen consecutive patients were selected to receive either

prophylactic analgesia with sublingual tramadol Hcl (50 mg) flashtabs and oral

lorazepam [(1 mg) analgesia group (AG), n=56] or oral diazepam (5 mg) alone

[nonAG (NAG), n=57]. Pain and anxiety levels were assessed using Visual Analogue

Scale (1-10) and State Anxiety Inventory, respectively, 30 min before, and 30

min and 6 h after the biopsy. RESULTS: The groups were comparable with respect

to baseline characteristics. Thirty minutes after the procedure, pain levels

were significantly lower in the AG (mean Visual Analogue Scale±standard error of

the mean, 1.8±0. 3; median=1) compared with the NAG (3.1±0.3, median=3;

P<0.005). Patients in the NAG (13.8%), reported high pain intensities (>7)

compared with the patients in the AG (3.6%; P=0.09). Six hours after the

procedure, pain intensity remained significantly lower in the AG compared with

the NAG (0.8±0.1 vs. 1.5±0.2; P<0.005). Anxiety levels were comparable.

CONCLUSION: Prophylactic combination of short-acting tramadol and lorazepam is

effective, safe, and can be used routinely before liver biopsy.