Impact of radiation and hepatitis virus infection on risk of hepatocellular carcinoma

[Guest guest]

Hepatology. 2011 Apr;53(4):1237-45. doi: 10.1002/hep.24207.

Impact of radiation and hepatitis virus infection on risk of hepatocellular

carcinoma.

Ohishi W, Fujiwara S, Cologne JB, Suzuki G, Akahoshi M, Nishi N, Tsuge M,

ma K.

Department of Clinical Studies, Hiroshima, Japan. nwaka@....

Abstract

In cohort studies of atomic bomb survivors and Mayak nuclear facility workers,

radiation-associated increases in liver cancer risk were observed, but hepatitis

B virus (HBV) and hepatitis C virus (HCV) infections were not taken strictly

into account. We identified 359 hepatocellular carcinoma (HCC) cases between

1970 and 2002 in the cohort of atomic bomb survivors and estimated cumulative

incidence of HCC by radiation dose. To investigate contributions of radiation

exposure and hepatitis virus infection to HCC risk, we conducted a nested

case-control study using sera stored before HCC diagnosis in the longitudinal

cohort of atomic bomb survivors. The study included 224 HCC cases and 644

controls that were matched to the cases on gender, age, city, and time and

method of serum storage, and countermatched on radiation dose. The cumulative

incidence of HCC by follow-up time and age increased significantly with

radiation dose. The relative risk (RR) of HCC for radiation at 1 Gy was 1.67

(95% confidence interval: 1.22-2.35) with adjustment for alcohol consumption,

body mass index (BMI), and smoking habit, whereas the RRs for HBV or HCV

infection alone were 63 (20-241) and 83 (36-231) with such adjustment,

respectively. Those estimates changed little when radiation and hepatitis virus

infection were fit simultaneously. The RR of non-B, non-C HCC at 1 Gy was 1.90

(1.02-3.92) without adjustment for alcohol consumption, BMI, or smoking habit

and 2.74 (1.26-7.04) with such adjustment. Conclusion: These results indicate

that radiation exposure and HBV and HCV infection are associated independently

with increased HCC risk. In particular, radiation exposure was a significant

risk factor for non-B, non-C HCC with no apparent confounding by alcohol

consumption, BMI, or smoking habit.

(HEPATOLOGY 2011;53:-).

Copyright © 2011 American Association for the Study of Liver Diseases.

PMID: 21480328 [PubMed - in process]

[Guest guest]

Hepatology. 2011 Apr;53(4):1237-45. doi: 10.1002/hep.24207.

Impact of radiation and hepatitis virus infection on risk of hepatocellular

carcinoma.

Ohishi W, Fujiwara S, Cologne JB, Suzuki G, Akahoshi M, Nishi N, Tsuge M,

ma K.

Department of Clinical Studies, Hiroshima, Japan. nwaka@....

Abstract

In cohort studies of atomic bomb survivors and Mayak nuclear facility workers,

radiation-associated increases in liver cancer risk were observed, but hepatitis

B virus (HBV) and hepatitis C virus (HCV) infections were not taken strictly

into account. We identified 359 hepatocellular carcinoma (HCC) cases between

1970 and 2002 in the cohort of atomic bomb survivors and estimated cumulative

incidence of HCC by radiation dose. To investigate contributions of radiation

exposure and hepatitis virus infection to HCC risk, we conducted a nested

case-control study using sera stored before HCC diagnosis in the longitudinal

cohort of atomic bomb survivors. The study included 224 HCC cases and 644

controls that were matched to the cases on gender, age, city, and time and

method of serum storage, and countermatched on radiation dose. The cumulative

incidence of HCC by follow-up time and age increased significantly with

radiation dose. The relative risk (RR) of HCC for radiation at 1 Gy was 1.67

(95% confidence interval: 1.22-2.35) with adjustment for alcohol consumption,

body mass index (BMI), and smoking habit, whereas the RRs for HBV or HCV

infection alone were 63 (20-241) and 83 (36-231) with such adjustment,

respectively. Those estimates changed little when radiation and hepatitis virus

infection were fit simultaneously. The RR of non-B, non-C HCC at 1 Gy was 1.90

(1.02-3.92) without adjustment for alcohol consumption, BMI, or smoking habit

and 2.74 (1.26-7.04) with such adjustment. Conclusion: These results indicate

that radiation exposure and HBV and HCV infection are associated independently

with increased HCC risk. In particular, radiation exposure was a significant

risk factor for non-B, non-C HCC with no apparent confounding by alcohol

consumption, BMI, or smoking habit.

(HEPATOLOGY 2011;53:-).

Copyright © 2011 American Association for the Study of Liver Diseases.

PMID: 21480328 [PubMed - in process]