Adherence to pegylated combination therapy in patients with chronic hepatitis C. Importance of the trio hepatologist general practitioner, nurse

[Guest guest]

Gastroenterol Clin Biol. 2008 Mar;32(3 Pt 2):S96-S108.

[Adherence to pegylated combination therapy in patients with chronic hepatitis

C. Importance of the trio hepatologist general practitioner, nurse]

[Article in French]

Wartelle-Bladou C, Rosenthal E, Ratziu V, De Lédinghen V, Lang JP, Poynard T.

Service d'Hépato-Gastroentérologie, Centre Hospitalier du Pays d'Aix, Avenue des

tamaris, 13616 Aix-en-Provence cedex 1, France. cwartelle@...

Adhesion to pegylated combination therapy is a key factor for therapeutic

success in patients HCV infected. To optimize it, goals to reach are to limit

dose reduction and premature discontinuation of treatment due to adverse events

; to improve the patient compliance to treatment, particularly during the first

three months, particularly to ribavirin. Therapeutic education, management of

psychiatric adverse events, epoetin alfa, have demonstrated their benefit in

terms of sustained virologic response or quality of life. Preparing the

treatment with the patient and a multi-disciplinary team, setting successive

therapeutic goals with the predictive value of the early virologic response will

promote adhesion to treatment. A hepatitis C training program for general

practitioners (GP) allows an efficient follow-up of treated patients by a trio

hepatologist - GP - nurse and a concrete implication of GP in the field of

hepatitis C. Further developments are needed for : taking in account the patient

quality of life during treatment to anticipate premature discontinuation,

promotion of therapeutic education by specialized nurses, standardization of the

diagnosis of depression during treatment, and regular updating of general

practitioners on antiviral C treatment.

Publication Types:

English Abstract

PMID: 18675187 [PubMed - in process]

[Guest guest]

Gastroenterol Clin Biol. 2008 Mar;32(3 Pt 2):S96-S108.

[Adherence to pegylated combination therapy in patients with chronic hepatitis

C. Importance of the trio hepatologist general practitioner, nurse]

[Article in French]

Wartelle-Bladou C, Rosenthal E, Ratziu V, De Lédinghen V, Lang JP, Poynard T.

Service d'Hépato-Gastroentérologie, Centre Hospitalier du Pays d'Aix, Avenue des

tamaris, 13616 Aix-en-Provence cedex 1, France. cwartelle@...

Adhesion to pegylated combination therapy is a key factor for therapeutic

success in patients HCV infected. To optimize it, goals to reach are to limit

dose reduction and premature discontinuation of treatment due to adverse events

; to improve the patient compliance to treatment, particularly during the first

three months, particularly to ribavirin. Therapeutic education, management of

psychiatric adverse events, epoetin alfa, have demonstrated their benefit in

terms of sustained virologic response or quality of life. Preparing the

treatment with the patient and a multi-disciplinary team, setting successive

therapeutic goals with the predictive value of the early virologic response will

promote adhesion to treatment. A hepatitis C training program for general

practitioners (GP) allows an efficient follow-up of treated patients by a trio

hepatologist - GP - nurse and a concrete implication of GP in the field of

hepatitis C. Further developments are needed for : taking in account the patient

quality of life during treatment to anticipate premature discontinuation,

promotion of therapeutic education by specialized nurses, standardization of the

diagnosis of depression during treatment, and regular updating of general

practitioners on antiviral C treatment.

Publication Types:

English Abstract

PMID: 18675187 [PubMed - in process]