Guest guest Posted September 8, 2008 Report Share Posted September 8, 2008 http://www3.interscience.wiley.com/journal/120848818/abstract Liver International Volume 28 Issue 9, Pages 1298 - 1304 Published Online: 25 Jul 2008 CLINICAL STUDIES Changing aetiology of liver dysfunction in the new generation of a hepatitis B and C-endemic area: cross-sectional studies on adolescents born in the first 10 years after universal hepatitis B vaccination Jung-Ta Kao 1 , Jing-Houng Wang 1 , Chao-Hung Hung 1 , Tsung-Hui Hu 1 , Chuan-Mo Lee 1 , Shu-Fen Hung 1 and Sheng-Nan Lu 1 1 Department of Internal Medicine, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Division of Hepato-Gastroenterology, Chang Gung University College of Medicine, Kaohsiung, Taiwan Correspondence Sheng-Nan Lu MD, MPH, PhD, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Division of Hepato-Gastroenterology, #123 Ta Pei Road, Niao Sung 833, Kaohsiung, Taiwan Tel: +886 7 731 7123, ext. 8301 Fax: +886 7 732 2402 e-mail: juten@... ABSTRACT Background/Aim: Geographical variation in viral hepatitis infection complicates various levels of liver diseases. This study elucidates the changing aetiology of alanine transaminase elevation (ALT levels>40 IU/L) in a previously hepatitis-endemic township. Design/Methods: Five cross-sectional screenings were performed on teenagers born from 1984 to 1993. We examined hepatitis B surface antigen (HBsAg), anti-hepatitis C virus (anti-HCV), ALT and body mass index, and additionally checked hepatitis B envelope antigen (HBeAg) for positive HBsAg and HCV RNA for positive anti-HCV. Teenagers with ALT elevation underwent an ultrasonography examination. Results: This study enrolled 1788 (93.7%) of 1909 students, discovering individual prevalence of HBsAg (6.3%), anti-hepatitis B core (anti-HBc) (15.5%), anti-HCV (2.2%), overweight (22.4%), obesity (12.8%) and ALT>40 IU/L (3.7%). HBsAg and anti-HBc prevalence declined with trends, while obesity increased with trends (P Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 8, 2008 Report Share Posted September 8, 2008 http://www3.interscience.wiley.com/journal/120848818/abstract Liver International Volume 28 Issue 9, Pages 1298 - 1304 Published Online: 25 Jul 2008 CLINICAL STUDIES Changing aetiology of liver dysfunction in the new generation of a hepatitis B and C-endemic area: cross-sectional studies on adolescents born in the first 10 years after universal hepatitis B vaccination Jung-Ta Kao 1 , Jing-Houng Wang 1 , Chao-Hung Hung 1 , Tsung-Hui Hu 1 , Chuan-Mo Lee 1 , Shu-Fen Hung 1 and Sheng-Nan Lu 1 1 Department of Internal Medicine, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Division of Hepato-Gastroenterology, Chang Gung University College of Medicine, Kaohsiung, Taiwan Correspondence Sheng-Nan Lu MD, MPH, PhD, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Division of Hepato-Gastroenterology, #123 Ta Pei Road, Niao Sung 833, Kaohsiung, Taiwan Tel: +886 7 731 7123, ext. 8301 Fax: +886 7 732 2402 e-mail: juten@... ABSTRACT Background/Aim: Geographical variation in viral hepatitis infection complicates various levels of liver diseases. This study elucidates the changing aetiology of alanine transaminase elevation (ALT levels>40 IU/L) in a previously hepatitis-endemic township. Design/Methods: Five cross-sectional screenings were performed on teenagers born from 1984 to 1993. We examined hepatitis B surface antigen (HBsAg), anti-hepatitis C virus (anti-HCV), ALT and body mass index, and additionally checked hepatitis B envelope antigen (HBeAg) for positive HBsAg and HCV RNA for positive anti-HCV. Teenagers with ALT elevation underwent an ultrasonography examination. Results: This study enrolled 1788 (93.7%) of 1909 students, discovering individual prevalence of HBsAg (6.3%), anti-hepatitis B core (anti-HBc) (15.5%), anti-HCV (2.2%), overweight (22.4%), obesity (12.8%) and ALT>40 IU/L (3.7%). HBsAg and anti-HBc prevalence declined with trends, while obesity increased with trends (P Quote Link to comment Share on other sites More sharing options...
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