The Expression of Hypoxia-Inducible Factor-1alpha in Hepatitis B Virus-Related Hepatocellular Carcin

[Guest guest]

Dig Dis Sci. 2008 May 9 [Epub ahead of print]

The Expression of Hypoxia-Inducible Factor-1alpha in Hepatitis B Virus-Related

Hepatocellular Carcinoma: Correlation with Patients' Prognosis and Hepatitis B

Virus X Protein.

Xie H, Song J, Liu K, Ji H, Shen H, Hu S, Yang G, Du Y, Zou X, Jin H, Yan L, Liu

J, Fan D.

State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing

Hospital, the Fourth Military Medical University, Xi’an, 710032, Shaanxi

Province, People’s Republic of China.

Hypoxia inducible factor-1alpha (HIF-1alpha) was well correlated with

carcinogenesis and tumor progression in many kinds of cancer. In this study,

high expression of HIF-1alpha was found in 37 of the 72 (51.39%) tumor

specimens, and significantly correlated with venous invasion and lymphonode

invasion. Patients with high expression of HIF-1alpha had a significantly

shorter overall survival rate and disease-free survival rate than those with low

expression. Multivariate analysis showed high HIF-1alpha expression was a

borderline independent factor of overall survival. HIF-1alpha expression was

also found to be significantly correlated with the expression of hepatitis B

virus X protein (HBx), and over-expressed HBx upregulated HIF-1alpha protein

expression in vitro. These results suggested that HIF-1alpha, which was

partially regulated by HBx, might be a prognostic marker of HBV-related HCC

patients.

PMID: 18465238 [PubMed - as supplied by publisher]

_________________________________________________________________

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_052008

[Guest guest]

Dig Dis Sci. 2008 May 9 [Epub ahead of print]

The Expression of Hypoxia-Inducible Factor-1alpha in Hepatitis B Virus-Related

Hepatocellular Carcinoma: Correlation with Patients' Prognosis and Hepatitis B

Virus X Protein.

Xie H, Song J, Liu K, Ji H, Shen H, Hu S, Yang G, Du Y, Zou X, Jin H, Yan L, Liu

J, Fan D.

State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing

Hospital, the Fourth Military Medical University, Xi’an, 710032, Shaanxi

Province, People’s Republic of China.

Hypoxia inducible factor-1alpha (HIF-1alpha) was well correlated with

carcinogenesis and tumor progression in many kinds of cancer. In this study,

high expression of HIF-1alpha was found in 37 of the 72 (51.39%) tumor

specimens, and significantly correlated with venous invasion and lymphonode

invasion. Patients with high expression of HIF-1alpha had a significantly

shorter overall survival rate and disease-free survival rate than those with low

expression. Multivariate analysis showed high HIF-1alpha expression was a

borderline independent factor of overall survival. HIF-1alpha expression was

also found to be significantly correlated with the expression of hepatitis B

virus X protein (HBx), and over-expressed HBx upregulated HIF-1alpha protein

expression in vitro. These results suggested that HIF-1alpha, which was

partially regulated by HBx, might be a prognostic marker of HBV-related HCC

patients.

PMID: 18465238 [PubMed - as supplied by publisher]

_________________________________________________________________

With Windows Live for mobile, your contacts travel with you.

http://www.windowslive.com/mobile/overview.html?ocid=TXT_TAGLM_WL_Refresh_mobile\

_052008