Clinical importance of serum hepatitis B surface antigen levels in chronic hepatitis B

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2893.2011.01486.x/abstract

Clinical importance of serum hepatitis B surface antigen levels in chronic

hepatitis B

S. Togo, M. Arai, A. Tawada, T. Chiba, T. Kanda, K. Fujiwara, F. Imazeki, O.

YokosukaArticle first published online: 22 JUL 2011

DOI: 10.1111/j.1365-2893.2011.01486.x

© 2011 Blackwell Publishing Ltd

Issue

Journal of Viral Hepatitis

Early View (Online Version of Record published before inclusion in an issue)

Summary.  Quantitative serology for hepatitis B surface antigen (HBsAg) is a

new candidate marker for prediction of clinical outcome. The aim of this study

was to investigate the clinical significance of quantifying HBsAg in patients

with hepatitis B virus (HBV) infection. A total of 424 patients who tested

positive for HBsAg and were referred to Chiba University Hospital between

January 1985 and April 2008 were included in the study, and the following

characteristics were analyzed: age, gender, status of hepatitis B e antigen

(HBeAg), alanine aminotransferase level (ALT), HBV DNA level, number of

platelets and development of hepatocellular carcinoma. Measurement of HBsAg was

performed using the chemiluminescent enzyme immunoassay method. The study group

consisted of 239 men and 185 women, and their average age was 40.6 ± 14.0

years. HBsAg showed a positive correlation with HBV DNA level (Pearson’s

product moment correlation, r = 0.586, P < 0.001) and a weak inverse correlation

with age (r = 0.3325, P < 0.001). A control study, matched with age and sex, was

performed between two groups with and without HBeAg seroconversion during

follow-up period. Compared with the age and sex-matched controls, the change in

HBsAg levels per year showed a significant decrease 2 years before

seroconversion (paired t-test, P < 0.05). The serial measurement of quantitative

HBsAg level has the possibility of predicting the occurrence of HBeAg

seroconversion.

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2893.2011.01486.x/abstract

Clinical importance of serum hepatitis B surface antigen levels in chronic

hepatitis B

S. Togo, M. Arai, A. Tawada, T. Chiba, T. Kanda, K. Fujiwara, F. Imazeki, O.

YokosukaArticle first published online: 22 JUL 2011

DOI: 10.1111/j.1365-2893.2011.01486.x

© 2011 Blackwell Publishing Ltd

Issue

Journal of Viral Hepatitis

Early View (Online Version of Record published before inclusion in an issue)

Summary.  Quantitative serology for hepatitis B surface antigen (HBsAg) is a

new candidate marker for prediction of clinical outcome. The aim of this study

was to investigate the clinical significance of quantifying HBsAg in patients

with hepatitis B virus (HBV) infection. A total of 424 patients who tested

positive for HBsAg and were referred to Chiba University Hospital between

January 1985 and April 2008 were included in the study, and the following

characteristics were analyzed: age, gender, status of hepatitis B e antigen

(HBeAg), alanine aminotransferase level (ALT), HBV DNA level, number of

platelets and development of hepatocellular carcinoma. Measurement of HBsAg was

performed using the chemiluminescent enzyme immunoassay method. The study group

consisted of 239 men and 185 women, and their average age was 40.6 ± 14.0

years. HBsAg showed a positive correlation with HBV DNA level (Pearson’s

product moment correlation, r = 0.586, P < 0.001) and a weak inverse correlation

with age (r = 0.3325, P < 0.001). A control study, matched with age and sex, was

performed between two groups with and without HBeAg seroconversion during

follow-up period. Compared with the age and sex-matched controls, the change in

HBsAg levels per year showed a significant decrease 2 years before

seroconversion (paired t-test, P < 0.05). The serial measurement of quantitative

HBsAg level has the possibility of predicting the occurrence of HBeAg

seroconversion.