Profile, spectrum and significance of HBV genotypes in chronic liver disease patients in the Indian subcontinent

[Guest guest]

Journal of Gastroenterology and Hepatology

Volume 17 Issue 2 Page 165 - February 2002

Profile, spectrum and significance of HBV genotypes in chronic liver

disease patients in the Indian subcontinent

VARSHA THAKUR*, RAJKUMAR CHANDRA GUPTAN*, SYED NAQUI KAZIM*, VEENA

MALHOTRA AND SHIV KUMAR SARIN*

ABSTRACT

BACKGROUND & AIM

Certain hepatitis B virus (HBV) genotypes have been alleged to be

associated with the development of cirrhosis and hepatocellular carcinoma

(HCC), and the response to interferon therapy in Taiwanese patients. We

undertook to study the prevalence and significance of HBV genotypes in the

Indian subcontinent.

METHODS

One hundred and thirty histopathologically proven chronic HBV-infected

patients, including 52 incidentally detected asymptomatic hepatitis B

surface antigen (HBsAg)-positive subjects (IDAHS) with chronic HBV infection

(group I), 48 cirrhotics (group II) and 30 hepatocellular carcinoma (HCC;

group III) patients were studied. Hepatitis B virus genotypes were

determined by using restriction fragment length polymorphism, and direct

sequencing of the s gene including the <IMG alt=`

src= " /na102/home/ACS/journals/entities/2018.png " align=bottom border=0>a

determinant region.

RESULTS

Only genotypes A (46) and D (48) were found in the chronic

HBV-infected patients. A mixed infection with genotypes A and D was seen in

6 of patients. Genotype A was found in 42, 48 and 50, and genotype D in 48,

50 and 47 of group I, II and III patients, respectively (P = NS). The

patients who had mixed genotypes were significantly younger (P< 0.05). In

group I (IDAHS) patients infected with genotype D, none had a histological

activity index (HAI) of < four. Genotype D was significantly more common in

group I patients with HAI > 4 as compared to genotype A (53 vs 32, P< 0.05).

Similarly, genotype D was associated with more severe liver diseases (61 vs

30, P< 0.05). Genotype D was more prevalent in HCC patients of < 40 years of

age, as compared to IDAHS (63 vs 44, P = 0.06).

CONCLUSIONS

(i) Hepatitis B virus genotypes A and D are prevalent in chronic liver

disease patients of Indian origin; and (ii) HBV genotype D is associated

with more severe diseases and may predict the occurrence of HCC in young

patients.

-------------------------------------

[Guest guest]

Journal of Gastroenterology and Hepatology

Volume 17 Issue 2 Page 165 - February 2002

Profile, spectrum and significance of HBV genotypes in chronic liver

disease patients in the Indian subcontinent

VARSHA THAKUR*, RAJKUMAR CHANDRA GUPTAN*, SYED NAQUI KAZIM*, VEENA

MALHOTRA AND SHIV KUMAR SARIN*

ABSTRACT

BACKGROUND & AIM

Certain hepatitis B virus (HBV) genotypes have been alleged to be

associated with the development of cirrhosis and hepatocellular carcinoma

(HCC), and the response to interferon therapy in Taiwanese patients. We

undertook to study the prevalence and significance of HBV genotypes in the

Indian subcontinent.

METHODS

One hundred and thirty histopathologically proven chronic HBV-infected

patients, including 52 incidentally detected asymptomatic hepatitis B

surface antigen (HBsAg)-positive subjects (IDAHS) with chronic HBV infection

(group I), 48 cirrhotics (group II) and 30 hepatocellular carcinoma (HCC;

group III) patients were studied. Hepatitis B virus genotypes were

determined by using restriction fragment length polymorphism, and direct

sequencing of the s gene including the <IMG alt=`

src= " /na102/home/ACS/journals/entities/2018.png " align=bottom border=0>a

determinant region.

RESULTS

Only genotypes A (46) and D (48) were found in the chronic

HBV-infected patients. A mixed infection with genotypes A and D was seen in

6 of patients. Genotype A was found in 42, 48 and 50, and genotype D in 48,

50 and 47 of group I, II and III patients, respectively (P = NS). The

patients who had mixed genotypes were significantly younger (P< 0.05). In

group I (IDAHS) patients infected with genotype D, none had a histological

activity index (HAI) of < four. Genotype D was significantly more common in

group I patients with HAI > 4 as compared to genotype A (53 vs 32, P< 0.05).

Similarly, genotype D was associated with more severe liver diseases (61 vs

30, P< 0.05). Genotype D was more prevalent in HCC patients of < 40 years of

age, as compared to IDAHS (63 vs 44, P = 0.06).

CONCLUSIONS

(i) Hepatitis B virus genotypes A and D are prevalent in chronic liver

disease patients of Indian origin; and (ii) HBV genotype D is associated

with more severe diseases and may predict the occurrence of HCC in young

patients.

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