Hepatocellular carcinoma appearance in patients with hepatitis C virus-related chronic liver disease

February 18, 2008

Liver International 28 (3) , 407–411 doi:10.1111/j.1478-3231.2007.01593.x

Abstract

CASE REPORT

Hepatocellular carcinoma appearance in patients with hepatitis C virus-related

chronic liver disease 90 and 70 months after sustained virological response to

interferon and ribavirin

Ranka Vukotic11 Semeiotica Medica, Dipartimento di Medicina Interna,

Cardioangiologia ed Epatologia, Università di Bologna, Bologna, Italy,

giulia Gramenzi11 Semeiotica Medica, Dipartimento di Medicina Interna,

Cardioangiologia ed Epatologia, Università di Bologna, Bologna, Italy, Giovanni

Vitale11 Semeiotica Medica, Dipartimento di Medicina Interna, Cardioangiologia

ed Epatologia, Università di Bologna, Bologna, Italy, Carmela Cursaro11

Semeiotica Medica, Dipartimento di Medicina Interna, Cardioangiologia ed

Epatologia, Università di Bologna, Bologna, Italy, Carla Serra22 Dipartimento di

Medicina Interna e Gastroenterologia, Università di Bologna, Bologna, Italy,

Maurizio Biselli11 Semeiotica Medica, Dipartimento di Medicina Interna,

Cardioangiologia ed Epatologia, Università di Bologna, Bologna, Italy,

Alessandra Scuteri11 Semeiotica Medica, Dipartimento di Medicina Interna,

Cardioangiologia ed Epatologia, Università di Bologna, Bologna, Italy, Pietro

Andreone11 Semeiotica Medica, Dipartimento di Medicina Interna, Cardioangiologia

ed Epatologia, Università di Bologna, Bologna, Italy and Mauro Bernardi11

Semeiotica Medica, Dipartimento di Medicina Interna, Cardioangiologia ed

Epatologia, Università di Bologna, Bologna, Italy1 Semeiotica Medica,

Dipartimento di Medicina Interna, Cardioangiologia ed Epatologia, Università di

Bologna, Bologna, Italy

2 Dipartimento di Medicina Interna e Gastroenterologia, Università di Bologna,

Bologna, Italy

Correspondence

Pietro Andreone, MD, Dipartimento di Medicina Interna, Cardioangiologia ed

Epatologia, Policlinico S.Orsola Malpighi, Via Massarenti, 9, 40138 Bologna,

Italy

Tel: +39 051 6363618

Fax: +39 051 345806

e-mail: pietro.andreone@...

Abstract

We report here two cases of hepatocellular carcinoma (HCC) 90 and 70 months,

respectively, after successful treatment with interferon (IFN) and ribavirin for

hepatitis C virus (HCV)-related cirrhosis. A 50-year-old Caucasian man and a

66-year-old Caucasian woman with HCV-related cirrhosis were treated with IFN and

ribavirin and in both cases a sustained virological response (SVR) was obtained

with persistent normalization of serum aminotransferases and continuous

disappearance of serum HCV-RNA. Both patients were subsequently followed up

within an HCC surveillance programme based on biochemical and ultrasound (US)

evaluation every 6 months and the appearance of HCC was detected 90 and 70

months, respectively, after discontinuation of therapy. We introduce these two

cases to call attention to the importance of not underestimating the risk of HCC

development even many years after complete HCV eradication, especially in the

presence of established cirrhosis and concomitance of other risk factors for

HCC.

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1478-3231.2007.01593.x

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February 18, 2008