Hepatitis B virus infection and risk of intrahepatic cholangiocarcinoma and non-Hodgkin lymphoma: A cohort study of parous women in Taiwan.

April 18, 2011

Hepatology. 2011 Apr;53(4):1217-25. doi: 10.1002/hep.24150.

Hepatitis B virus infection and risk of intrahepatic cholangiocarcinoma and

non-Hodgkin lymphoma: A cohort study of parous women in Taiwan.

Fwu CW, Chien YC, You SL, KE, Kirk GD, Kuo HS, Feinleib M, Chen CJ.

Department of Epidemiology, s Hopkins University Bloomberg School of Public

Health, Baltimore, MD.

Abstract

Few studies have evaluated the risk of cancers other than hepatocellular

carcinoma associated with hepatitis B virus (HBV) infection. This study aimed to

estimate incidence rates of intrahepatic cholangiocarcinoma (ICC) and

non-Hodgkin lymphoma (NHL) and its major subtypes in a nationwide cohort of

parous women and to assess their associations with chronic HBV infection. We

conducted a cohort study including 1,782,401 pregnant Taiwanese women whose HBV

serostatus was obtained from the National Hepatitis B Vaccination Registry.

Newly diagnosed ICCs and NHLs were ascertained through data linkage with the

National Cancer Registry. Risks of ICC and NHL were assessed using

proportional hazards regression models. After a mean of 6.91 years of follow-up,

there were 18 cases of ICC and 192 cases of NHL, including 99 cases of diffuse

large B-cell lymphoma (DLBCL). Incidence rates of ICC were 0.09 and 0.43 per

100,000 person-years, respectively, among women who were hepatitis B surface

antigen (HBsAg)-seronegative and HBsAg-seropositive, showing an age-adjusted

hazard ratio (HR(adj) ) (95% confidence interval [CI]) of 4.80 (1.88-12.20). The

incidence rates of NHL overall for HBsAg-seronegative and HBsAg-seropositive

women were 1.23 and 3.18 per 100,000 person-years, respectively, with an HR(adj)

(95% CI) of 2.63 (1.95-3.54). Among NHL subtypes, HBsAg-seropositive women had

an increased risk of DLBCL compared with those who were HBsAg-seronegative

(incidence rates: 1.81 and 0.60 per 100,000 person-years, respectively; HR(adj)

[95% CI]: 3.09 [2.06-4.64]). The significantly increased risk was not observed

for other specific subtypes of NHL. Conclusions: Chronic HBV infection was

associated with an increased risk of ICC and DLBCL in women. Our data suggested

a possible etiological role of HBV in the development of ICC and specific

subtypes of NHL.

(HEPATOLOGY 2011;).

PMID: 21480326 [PubMed - in process]

April 18, 2011