Mother-to-infant transmission of hepatitis B virus: A chinese experience

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J Med Virol. 2011 Feb 25. doi: 10.1002/jmv.22043. [Epub ahead of print]

Mother-to-infant transmission of hepatitis B virus: A chinese experience.

Shao ZJ, Zhang L, Xu JQ, Xu DZ, Men K, Zhang JX, Cui HC, Yan YP.

Department of Epidemiology, School of Public Health, The Fourth Military Medical

University, Xi'an, China.

Abstract

Over 90% of infants infected with hepatitis B virus (HBV) caused by

mother-to-infant transmission will evolve to carrier status, and this cannot be

prevented until widespread administration of the HB vaccine and hepatitis B

immune globulin (HBIG) is implemented. This prospective study of 214 infants

born to HBsAg-positive mothers was carried out to determine if either perinatal

or intrauterine HBV transmission could be effectively prevented with HBIG and

the HB vaccine. Peripheral blood was collected from mothers and from newborns

before they received HBIG and the HB vaccine, as well as at 0, 1, 7, 24, and

36 months after birth. Infants born with an ratio of signal to noise(S/N)

value of >5 for HBsAg (ABBOTT Diagnostic Kit) were defined as mother-to-infant

transmission cases, those with an S/N between 5 and 50 were classified as

perinatal transmission cases, and those with an S/N >50 were considered

intrauterine transmission cases. Mother-to-infant transmission occurred in

approximately 4.7% (10/214) of the infants; the perinatal transmission and

intrauterine transmission rates were 3.7% (8/214) and 0.9% (2/214),

respectively. The risk of mother-to-infant transmission increased along with

maternal HBeAg or HBVDNA levels. After 36 months of follow-up, all perinatal

cases became HBsAg-negative, whereas all intrauterine transmission cases evolved

into carrier status. These results indicate that infants infected via

intrauterine transmission cannot be effectively protected by HBIG and HB

vaccine.

J. Med. Virol. © 2011 Wiley-Liss, Inc.

Copyright © 2011 Wiley-Liss, Inc.

PMID: 21360547 [PubMed - as supplied by publisher]

[Guest guest]

J Med Virol. 2011 Feb 25. doi: 10.1002/jmv.22043. [Epub ahead of print]

Mother-to-infant transmission of hepatitis B virus: A chinese experience.

Shao ZJ, Zhang L, Xu JQ, Xu DZ, Men K, Zhang JX, Cui HC, Yan YP.

Department of Epidemiology, School of Public Health, The Fourth Military Medical

University, Xi'an, China.

Abstract

Over 90% of infants infected with hepatitis B virus (HBV) caused by

mother-to-infant transmission will evolve to carrier status, and this cannot be

prevented until widespread administration of the HB vaccine and hepatitis B

immune globulin (HBIG) is implemented. This prospective study of 214 infants

born to HBsAg-positive mothers was carried out to determine if either perinatal

or intrauterine HBV transmission could be effectively prevented with HBIG and

the HB vaccine. Peripheral blood was collected from mothers and from newborns

before they received HBIG and the HB vaccine, as well as at 0, 1, 7, 24, and

36 months after birth. Infants born with an ratio of signal to noise(S/N)

value of >5 for HBsAg (ABBOTT Diagnostic Kit) were defined as mother-to-infant

transmission cases, those with an S/N between 5 and 50 were classified as

perinatal transmission cases, and those with an S/N >50 were considered

intrauterine transmission cases. Mother-to-infant transmission occurred in

approximately 4.7% (10/214) of the infants; the perinatal transmission and

intrauterine transmission rates were 3.7% (8/214) and 0.9% (2/214),

respectively. The risk of mother-to-infant transmission increased along with

maternal HBeAg or HBVDNA levels. After 36 months of follow-up, all perinatal

cases became HBsAg-negative, whereas all intrauterine transmission cases evolved

into carrier status. These results indicate that infants infected via

intrauterine transmission cannot be effectively protected by HBIG and HB

vaccine.

J. Med. Virol. © 2011 Wiley-Liss, Inc.

Copyright © 2011 Wiley-Liss, Inc.

PMID: 21360547 [PubMed - as supplied by publisher]