Comparable Ten-Year Outcome in Hemodialysis Patients with Hepatitis C Virus and Hepatitis B Virus Coinfection and Single Hepatitis B Virus Infection

March 8, 2011

324196 & Ausgabe=255014 & ProduktNr=223997

Original Paper

Comparable Ten-Year Outcome in Hemodialysis Patients with Hepatitis C Virus and

Hepatitis B Virus Coinfection and Single Hepatitis B Virus Infection

Cheng-Chia Leea, I-Jung Lia, b, Yung-Chang Chena, Jen-Wei Chenga, Hsin-Hsu Wua,

b, Cheng-Hao Wenga, b, Ji-Tseng Fanga, Ya-Chung Tiana

aDepartment of Nephrology, Lin-Kou Chang Gung Memorial Hospital, Taipei, and

Department of Medicine, Chang Gung University, and

bGraduate Institute of Clinical Medical Sciences, Chang Gung University, Tao

Yuan, Taiwan, ROC

Address of Corresponding Author

Blood Purif 2011;32:89-95 (DOI: 10.1159/000324196)

Abstract

Hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection in comparison

with single HBV infection causes more severe liver disease in nonuremic

population. The long-term impact of HBV/HCV coinfection on severity of liver

diseases and patient survival in hemodialysis patients is unclear. Forty-eight

HBV-positive patients and 19 HBV/HCV-positive patients were followed up from

February 1996 to September 2006. During 10-year follow-up, there was no

difference in acute hepatitis episodes, abnormal serum alanine aminotransferase

period, occurrence of cirrhosis and hepatocellular carcinoma, and patient

survival between the two groups. The serum HBV DNA levels in HBV/HCV-positive

patients were significantly lower than those in HBV-positive patients during the

first 27-month follow-up. In conclusion, HCV infection suppresses the serum HBV

DNA level in hemodialysis patients. Nevertheless, HBV/HCV coinfection in

comparison with single HBV infection does not cause more severe liver diseases

or reduce patient survival in hemodialysis patients during 10-year follow-up.

March 8, 2011