Vaccine-strain Varicella Shedding Detected Up to Month After Zoster Vaccination (shingles vax)

March 10, 2011

shingles vaccine - (which means you

can catch vax version of chickenpox from these people who had this

vaccine, up to 1 month after the vaccine)

Varicella Shedding Detected Up to Month After Zoster Vaccination

By: BRUCE JANCIN, Internal Medicine News

Digital Network

http://www.internalmedicinenews.com/news/infectious-diseases/single-article/varicella-shedding-detected-up-to-month-after-zoster-vaccination/8f6b51d39f.html

NEW ORLEANS – Varicella zoster virus DNA was detected in subjects’ saliva

for a month after immunization with the Zostavax herpes zoster vaccine in

a prospective study. Genotypic analysis demonstrated that the varicella

zoster virus that was present in saliva was indeed the Zostavax live

attenuated vaccine virus, Dr. M. DiGiorgio said at the annual

meeting of the American Academy of Dermatology....

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Not that viruses ever cause anything - just because present, does not

mean cause? I do not think we are told the truth about what viruses

are or are not...Sheri

Do viruses cause

inner ear disturbances?

Pyykko I, Zou J.

ORL J Otorhinolaryngol Relat Spec. 2008;70(1):32-40; discussion

40-1

The association of viral infection to inner ear disease is controversial.

Experiments on animals show that several viruses are capable of causing

hearing loss, if applied into the perilymph. Some of these have specific

affinity to the cellular type of the inner ear, as sensory epithelia and

cochlear nerve. Some viruses as adenoviruses and sackie virus B have

specific CAR receptors that are identified in different cell types,

whereas other act by attaching onto nonspecific cellular surface

receptors. Some viruses such as varicella zoster virus (VZV) do not cause

disease in rodents. We assessed 273 patients with clinical, serological,

neuro-otologic and endoscopic evaluations. Of the 273 patients, 43 served

as control subjects. The patients either had Ménière's disease (n = 158),

recurrent vertigo of unknown etiology (n = 56), or hearing loss (n = 17).

Antibodies against neurotropic and common viruses were evaluated. VZV,

influenza B, CBV5 and RSV titers were significantly elevated in patients

with inner ear disease when compared with the control group. In analyzing

the internal relationship, VZV and influenza B were intercorrelated. We

did not find a correlation between hearing loss and viral titers. In

conclusion, VZV, sackie virus B5 and influenza B virus may be the main

causes of inner ear disorder. The spiral and Scarpa's ganglion are

potential sites harboring viral DNA for possible latent infection.

Presence of

herpesviruses in middle ear fluid of children with otitis media with

effusion.

Bulut Y, Karlidag T, Seyrek A, Keles E, Toraman ZA.

Pediatr Int. 2007 Feb;49(1):36-9.

BACKGROUND: Otitis media with effusion (OME) is a disease that frequently

occurs in children. Etiopathogenesis of the diseases has not been

completely elucidated. There are limited numbers of studies on the

presence of herpesviruses in otitis media cases with OME. The present

study was undertaken to determine the rate of some herpesviruses in OME

cases of children.

METHODS: A total of 92-middle ear fluids were collected from 51 children.

The samples were analyzed using polymerase chain reaction (PCR) for

detection of herpesviruses including Herpes simplex virus (HSV),

cytomegalovirus (CMV), Varicella zoster virus (VZV), and Epstein-Barr

virus (EBV).

RESULTS: PCR analysis of the 92 samples showed that genomes of EBV in 12

(13.04%), HSV in seven (7.60%), CMV in five (5.43%), and VZV in three

(3.26%) were present. Two of these samples were positive for both HSV and

EBV genomes. Therefore, 25 (27.17%) of the samples were determined to be

infected with any of the herpesviruses tested.

CONCLUSIONS: In the present study, herpesviruses were determined at a

high rate in middle ear fluids of children with OME. However, the present

study is a preliminary study and more extensive studies, especially

experimental studies, are required to elucidate the role of herpesviruses

in pathogenesis of OME and whether there is a relation between rate of

herpesviruses in OME cases, and the reactivation of latent

infections.

Presence of

cytomegalovirus and herpes simplex virus in middle ear fluids from

children with acute otitis media.

Chonmaitree T, Owen MJ, Patel JA, Hedgpeth D, Horlick D,

Howie VM.

Clin Infect Dis. 1992 Oct;15(4):650-3.

Twenty-seven (10%) of 271 infants and children with acute otitis media

(AOM) were found to be infected with cytomegalovirus (CMV) or herpes

simplex virus type 1 (HSV). CMV or HSV, alone or in combination with

bacteria or other viruses, was isolated from the middle ear fluid (MEF)

of 10 patients. In three cases, CMV alone was isolated from the MEF, and

in one case, HSV alone was isolated. One of the CMV cases involved an

acute primary or reactivation of CMV infection, with CMV-bacterial otitis

and conjunctivitis as major manifestations. One patient with AOM and

stomatitis had purulent otitis associated with the presence of HSV in

MEF, with no other bacterial or viral pathogens noted in MEF or nasal

wash specimens. While most patients with CMV infection were probably

asymptomatic excreters at the time of development of AOM, CMV did enter

the middle ear. The presence of CMV in MEF was prolonged, and the

patients continued to have clinical signs of otitis despite negative

bacterial cultures. Among patients with bacterial otitis, a higher

proportion of those who had CMV found only in nasal wash specimens had

persistent bacteria in MEF, compared with those who were concurrently

infected with other viruses (57% vs. 19%; P less than .04). This report

is the first to suggest an etiologic role for CMV and HSV in

AOM.

March 10, 2011