Hepatitis B virus genotype B with G1896A and A1762T/G1764A mutations is associated with hepatitis B related acute-on-chronic liver failure

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http://www.ncbi.nlm.nih.gov/pubmed/21739444

J Med Virol. 2011 Sep;83(9):1544-50. doi: 10.1002/jmv.22159.

Hepatitis B virus genotype B with G1896A and A1762T/G1764A mutations is

associated with hepatitis B related acute-on-chronic liver failure.

Xiao L, Zhou B, Gao H, Ma S, Yang G, Xu M, Abbott WG, Chen J, Sun J, Wang Z, Hou

J.

Source

Hepatology Unit and Key Lab for Organ Failure Research, Nanfang Hospital,

Southern Medical University, Guangzhou, China.

Abstract

The existence of statistical associations between hepatitis B-related

acute-on-chronic liver failure and both hepatitis B virus (HBV) genotype and

mutations in the basal core promoter (BCP) and precore (PC) regions needs to be

confirmed. A total of 322 patients with a chronic HBV infection, including 77

with hepatitis B-related acute-on-chronic liver failure, 109 with hepatocellular

carcinoma (HCC) and 136 with chronic hepatitis B (CHB) were enrolled. The HBV

genotype and the presence of mutations in the BCP/PC regions were determined by

direct sequencing, and the frequencies were compared in the three patient

groups. Overall, 198/322 (61.5%) were infected with genotype B and 124/322

(38.5%) with genotype C. Genotype B was significantly more frequent in patients

with acute-on-chronic liver failure than CHB (92.2% vs. 60.3%, P < 0.001).

As a contrast, genotype C was more common in patients with HCC than CHB (58.7%

vs. 39.7%, P = 0.003). In genotype B patients, the A1762T/G1764A, A1846T,

and G1896A mutations were significantly more prevalent in patients with

acute-on-chronic liver failure than CHB (50.7% vs. 28.0%, P = 0.004; 59.2%

vs. 34.1%, P = 0.002; 69.0% vs. 41.5%, P = 0.001, respectively). In

multivariate analysis, the risk factors for acute-on-chronic liver failure were

genotype B, A1762T/G1764A, and G1896A. In conclusion, CHB patients with genotype

B, G1896A, and A1762T/G1764A had a higher tendency to develop liver failure than

patients with genotype C. Therefore, HBV genotyping and detecting G1896A and

A1762T/G1764A mutations might have important clinical implications as predictive

risk factors for hepatitis B-related acute-on-chronic liver failure. J. Med.

Virol. 83:1544-1550, 2011. © 2011 Wiley-Liss, Inc.

Copyright © 2011 Wiley-Liss, Inc.

PMID: 21739444 [PubMed - in process]

[Guest guest]

http://www.ncbi.nlm.nih.gov/pubmed/21739444

J Med Virol. 2011 Sep;83(9):1544-50. doi: 10.1002/jmv.22159.

Hepatitis B virus genotype B with G1896A and A1762T/G1764A mutations is

associated with hepatitis B related acute-on-chronic liver failure.

Xiao L, Zhou B, Gao H, Ma S, Yang G, Xu M, Abbott WG, Chen J, Sun J, Wang Z, Hou

J.

Source

Hepatology Unit and Key Lab for Organ Failure Research, Nanfang Hospital,

Southern Medical University, Guangzhou, China.

Abstract

The existence of statistical associations between hepatitis B-related

acute-on-chronic liver failure and both hepatitis B virus (HBV) genotype and

mutations in the basal core promoter (BCP) and precore (PC) regions needs to be

confirmed. A total of 322 patients with a chronic HBV infection, including 77

with hepatitis B-related acute-on-chronic liver failure, 109 with hepatocellular

carcinoma (HCC) and 136 with chronic hepatitis B (CHB) were enrolled. The HBV

genotype and the presence of mutations in the BCP/PC regions were determined by

direct sequencing, and the frequencies were compared in the three patient

groups. Overall, 198/322 (61.5%) were infected with genotype B and 124/322

(38.5%) with genotype C. Genotype B was significantly more frequent in patients

with acute-on-chronic liver failure than CHB (92.2% vs. 60.3%, P < 0.001).

As a contrast, genotype C was more common in patients with HCC than CHB (58.7%

vs. 39.7%, P = 0.003). In genotype B patients, the A1762T/G1764A, A1846T,

and G1896A mutations were significantly more prevalent in patients with

acute-on-chronic liver failure than CHB (50.7% vs. 28.0%, P = 0.004; 59.2%

vs. 34.1%, P = 0.002; 69.0% vs. 41.5%, P = 0.001, respectively). In

multivariate analysis, the risk factors for acute-on-chronic liver failure were

genotype B, A1762T/G1764A, and G1896A. In conclusion, CHB patients with genotype

B, G1896A, and A1762T/G1764A had a higher tendency to develop liver failure than

patients with genotype C. Therefore, HBV genotyping and detecting G1896A and

A1762T/G1764A mutations might have important clinical implications as predictive

risk factors for hepatitis B-related acute-on-chronic liver failure. J. Med.

Virol. 83:1544-1550, 2011. © 2011 Wiley-Liss, Inc.

Copyright © 2011 Wiley-Liss, Inc.

PMID: 21739444 [PubMed - in process]