Pregnancy outcomes associated with viral hepatitis

[Guest guest]

J Viral Hepat. 2011 Jul;18(7):e394-8. doi: 10.1111/j.1365-2893.2011.01436.x.

Epub 2011 Feb 8.Pregnancy outcomes associated with viral hepatitis.Reddick KL,

Jhaveri R, Gandhi M, AH, Swamy GK.SourceDepartment of Obstetrics and

Gynecology Department of Pediatrics Department of Molecular Genetics and

Microbiology Research on Research Group, Duke University Medical Center, Durham,

NC, USA Department of Biostatistics, Singapore Clinical Research Institute,

Singapore, Singapore.AbstractSummary.  The aim of this study was to examine

the contribution of hepatitis B virus (HBV) and hepatitis C virus (HCV) to

pregnancy-related complications including gestational diabetes mellitus (GDM),

preterm birth (PTB), intrauterine growth restriction (IUGR), pre-eclampsia,

antepartum haemorrhage and cholestasis. The Nationwide Inpatient Sample was

queried for all pregnancy-related discharges, pregnancy complications and viral

hepatitis from 1995 to 2005. Logistic regression was used to examine the

association between HBV, HCV, HBV + HCV and pregnancy-related complications

including GDM, PTB, IUGR, pre-eclampsia, antepartum haemorrhage, cholestasis and

caesarean delivery. Model covariates included maternal age, race, insurance

status, substance use and medical complications including liver complication,

hypertension, HIV, anaemia, thrombocytopenia and sexually transmitted

infections. Of 297 664 pregnant women data available for analysis, 1446 had a

coded diagnosis of HBV, HCV or both. High-risk behaviours, such as smoking,

alcohol and substance use were higher in women with either HBV or HCV. Women

with HBV had an increased risk for PTB (aOR 1.65, CI [1.3, 2.0]) but a decreased

risk for caesarean delivery (aOR 0.686, CI [0.53, 0.88]). Individuals with HCV

had an increased risk for GDM (aOR 1.6, CI [1.0, 2.6]). Individuals with both

HBV and HCV co-infection had an increased risk for antepartum haemorrhage (aOR

2.82, CI [1.1, 7.2]). There was no association of viral hepatitis with IUGR or

pre-eclampsia. Women with hepatitis have an increased risk for complications

during pregnancy. Research to determine the efficacy and cost-effectiveness of

counselling patients about potential risks for adverse outcomes is warranted.©

2011 Blackwell Publishing Ltd.PMID: 21692952 [PubMed - in process]

[Guest guest]

J Viral Hepat. 2011 Jul;18(7):e394-8. doi: 10.1111/j.1365-2893.2011.01436.x.

Epub 2011 Feb 8.Pregnancy outcomes associated with viral hepatitis.Reddick KL,

Jhaveri R, Gandhi M, AH, Swamy GK.SourceDepartment of Obstetrics and

Gynecology Department of Pediatrics Department of Molecular Genetics and

Microbiology Research on Research Group, Duke University Medical Center, Durham,

NC, USA Department of Biostatistics, Singapore Clinical Research Institute,

Singapore, Singapore.AbstractSummary.  The aim of this study was to examine

the contribution of hepatitis B virus (HBV) and hepatitis C virus (HCV) to

pregnancy-related complications including gestational diabetes mellitus (GDM),

preterm birth (PTB), intrauterine growth restriction (IUGR), pre-eclampsia,

antepartum haemorrhage and cholestasis. The Nationwide Inpatient Sample was

queried for all pregnancy-related discharges, pregnancy complications and viral

hepatitis from 1995 to 2005. Logistic regression was used to examine the

association between HBV, HCV, HBV + HCV and pregnancy-related complications

including GDM, PTB, IUGR, pre-eclampsia, antepartum haemorrhage, cholestasis and

caesarean delivery. Model covariates included maternal age, race, insurance

status, substance use and medical complications including liver complication,

hypertension, HIV, anaemia, thrombocytopenia and sexually transmitted

infections. Of 297 664 pregnant women data available for analysis, 1446 had a

coded diagnosis of HBV, HCV or both. High-risk behaviours, such as smoking,

alcohol and substance use were higher in women with either HBV or HCV. Women

with HBV had an increased risk for PTB (aOR 1.65, CI [1.3, 2.0]) but a decreased

risk for caesarean delivery (aOR 0.686, CI [0.53, 0.88]). Individuals with HCV

had an increased risk for GDM (aOR 1.6, CI [1.0, 2.6]). Individuals with both

HBV and HCV co-infection had an increased risk for antepartum haemorrhage (aOR

2.82, CI [1.1, 7.2]). There was no association of viral hepatitis with IUGR or

pre-eclampsia. Women with hepatitis have an increased risk for complications

during pregnancy. Research to determine the efficacy and cost-effectiveness of

counselling patients about potential risks for adverse outcomes is warranted.©

2011 Blackwell Publishing Ltd.PMID: 21692952 [PubMed - in process]