[Vaccinations] Study confirms Parkinson's-pesticides link: organochlorines and organophosphorus compounds

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Stop Vaccines <vaccineinfo@...> wrote: From: Binstock <binstockpeakpeak>Study as published is free online, via 2nd url hereinbelow. Note that organochlorines and organophosphorus compounds are associated with autism (D'Amelio et al 2005; Windham et al 2007).- - - -Study confirms Parkinson's-pesticides linkFri Apr 18, 2008Reuters<http://www.reutershealth.com/archive/>http://www.reutershealth.com/archive/2008/04/18/eline/links/20080418elin027.htmlNEW YORK (Reuters Health) - Results of a family-based, "case-control" study support a relationship between exposure to pesticides and the development of Parkinson's disease (PD).Prior studies have shown that people with Parkinson's disease are over twice as likely to report being exposed to pesticides as people without the disease, but few studies have looked at this association in people from the same family or have assessed associations between specific classes of pesticides and Parkinson's disease.In their study of 319 Parkinson's patients and more than 200 unaffected relatives, Dr. Dana Hancock from Duke University, Durham,

North Carolina and colleagues found that the Parkinson's patients were 61 percent more likely to report direct pesticide application than were healthy relatives.Both insecticides and herbicides -- most notably organochlorines, organophosphorus compounds, chlorophenoxy acids/esters, and botanicals -- significantly increased the risk of Parkinson's disease, the researchers report in the online journal BioMedCentral (BMC) Neurology."Further investigation of these specific pesticides and others may lead to identification of pertinent biological pathways influencing Parkinson's disease development," the investigators suggest.It's also worth noting, they say, that "the strongest associations between Parkinson's disease and pesticides were obtained in families with no history of Parkinson's. "This finding suggests that sporadic Parkinson's cases may be particularly vulnerable to the toxic effects of

pesticides, but the possibility of pesticides influencing risk of Parkinson's in individuals from families with a history of PD cannot be ruled out."SOURCE: BioMedCentral-Neurology 2008.- - - -Pesticide exposure and risk of Parkinson's disease: a family-based case-control study.Hancock DB et al.BMC Neurol. 2008 Mar 28;8:6.<http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed & pubmedid=18373838>http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed & pubmedid=18373838BACKGROUND: Pesticides and correlated lifestyle factors (e.g., exposure to well-water and farming) are repeatedly reported risk factors for Parkinson's disease (PD),

but few family-based studies have examined these relationships. METHODS: Using 319 cases and 296 relative and other controls, associations of direct pesticide application, well-water consumption, and farming residences/occupations with PD were examined using generalized estimating equations while controlling for age-at-examination, sex, cigarette smoking, and caffeine consumption. RESULTS: Overall, individuals with PD were significantly more likely to report direct pesticide application than their unaffected relatives (odds ratio = 1.61; 95% confidence interval, 1.13-2.29). Frequency, duration, and cumulative exposure were also significantly associated with PD in a dose-response pattern (p </= 0.013). Associations of direct pesticide application did not vary by sex but were modified by family history of PD, as significant associations were restricted to individuals with no family history. When classifying

pesticides by functional type, both insecticides and herbicides were found to significantly increase risk of PD. Two specific insecticide classes, organochlorines and organophosphorus compounds, were significantly associated with PD. Consuming well-water and living/working on a farm were not associated with PD. CONCLUSION: These data corroborate positive associations of broadly defined pesticide exposure with PD in families, particularly for sporadic PD. These data also implicate a few specific classes of pesticides in PD and thus emphasize the need to consider a more narrow definition of pesticides in future studies.PMID: 18373838The material in this post is distributed withoutprofit to those who have expressed a prior interestin receiving the included information for researchand educational purposes.For more information go to:<http://www4.law.cornell.edu/uscode/17/107.html>http://www4.law.cornell.edu/uscode/17/107.htmlhttp://oregon.uoregon.edu/~csundt/documents.htmIf you wish to use copyrighted material from thisemail for purposes that go beyond 'fair use', youmust obtain permission from the copyright owner.--------------------------------------------------------Sheri Nakken, former R.N., MA, Hahnemannian HomeopathVaccination Information & Choice Network, Nevada City CA & Wales UKVaccines - http://www.wellwithin1.com/vaccine.htmVaccine Dangers & Homeopathy Online/email courses[Non-text portions of this message have been

removed]

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Stop Vaccines <vaccineinfo@...> wrote: From: Binstock <binstockpeakpeak>Study as published is free online, via 2nd url hereinbelow. Note that organochlorines and organophosphorus compounds are associated with autism (D'Amelio et al 2005; Windham et al 2007).- - - -Study confirms Parkinson's-pesticides linkFri Apr 18, 2008Reuters<http://www.reutershealth.com/archive/>http://www.reutershealth.com/archive/2008/04/18/eline/links/20080418elin027.htmlNEW YORK (Reuters Health) - Results of a family-based, "case-control" study support a relationship between exposure to pesticides and the development of Parkinson's disease (PD).Prior studies have shown that people with Parkinson's disease are over twice as likely to report being exposed to pesticides as people without the disease, but few studies have looked at this association in people from the same family or have assessed associations between specific classes of pesticides and Parkinson's disease.In their study of 319 Parkinson's patients and more than 200 unaffected relatives, Dr. Dana Hancock from Duke University, Durham,

North Carolina and colleagues found that the Parkinson's patients were 61 percent more likely to report direct pesticide application than were healthy relatives.Both insecticides and herbicides -- most notably organochlorines, organophosphorus compounds, chlorophenoxy acids/esters, and botanicals -- significantly increased the risk of Parkinson's disease, the researchers report in the online journal BioMedCentral (BMC) Neurology."Further investigation of these specific pesticides and others may lead to identification of pertinent biological pathways influencing Parkinson's disease development," the investigators suggest.It's also worth noting, they say, that "the strongest associations between Parkinson's disease and pesticides were obtained in families with no history of Parkinson's. "This finding suggests that sporadic Parkinson's cases may be particularly vulnerable to the toxic effects of

pesticides, but the possibility of pesticides influencing risk of Parkinson's in individuals from families with a history of PD cannot be ruled out."SOURCE: BioMedCentral-Neurology 2008.- - - -Pesticide exposure and risk of Parkinson's disease: a family-based case-control study.Hancock DB et al.BMC Neurol. 2008 Mar 28;8:6.<http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed & pubmedid=18373838>http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed & pubmedid=18373838BACKGROUND: Pesticides and correlated lifestyle factors (e.g., exposure to well-water and farming) are repeatedly reported risk factors for Parkinson's disease (PD),

but few family-based studies have examined these relationships. METHODS: Using 319 cases and 296 relative and other controls, associations of direct pesticide application, well-water consumption, and farming residences/occupations with PD were examined using generalized estimating equations while controlling for age-at-examination, sex, cigarette smoking, and caffeine consumption. RESULTS: Overall, individuals with PD were significantly more likely to report direct pesticide application than their unaffected relatives (odds ratio = 1.61; 95% confidence interval, 1.13-2.29). Frequency, duration, and cumulative exposure were also significantly associated with PD in a dose-response pattern (p </= 0.013). Associations of direct pesticide application did not vary by sex but were modified by family history of PD, as significant associations were restricted to individuals with no family history. When classifying

pesticides by functional type, both insecticides and herbicides were found to significantly increase risk of PD. Two specific insecticide classes, organochlorines and organophosphorus compounds, were significantly associated with PD. Consuming well-water and living/working on a farm were not associated with PD. CONCLUSION: These data corroborate positive associations of broadly defined pesticide exposure with PD in families, particularly for sporadic PD. These data also implicate a few specific classes of pesticides in PD and thus emphasize the need to consider a more narrow definition of pesticides in future studies.PMID: 18373838The material in this post is distributed withoutprofit to those who have expressed a prior interestin receiving the included information for researchand educational purposes.For more information go to:<http://www4.law.cornell.edu/uscode/17/107.html>http://www4.law.cornell.edu/uscode/17/107.htmlhttp://oregon.uoregon.edu/~csundt/documents.htmIf you wish to use copyrighted material from thisemail for purposes that go beyond 'fair use', youmust obtain permission from the copyright owner.--------------------------------------------------------Sheri Nakken, former R.N., MA, Hahnemannian HomeopathVaccination Information & Choice Network, Nevada City CA & Wales UKVaccines - http://www.wellwithin1.com/vaccine.htmVaccine Dangers & Homeopathy Online/email courses[Non-text portions of this message have been

removed]