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PSI-7977 with Standard Therapy Produces 91% Sustained

ResponseThe experimental hepatitis C virus (HCV)

nucleotide analog polymerase inhibitor PSI-7977, used in

combination with pegylated interferon and ribavirin,

demonstrated a 12-week sustained virological response

rate of 91% for previously untreated genotype 1 chronic

hepatitis C patients in the ongoing PROTON trial.HALT-C

Finds High Rate of Liver-Related Death and Transplants

among Interferon Non-RespondersChronic hepatitis C

patients in the HALT-C study who did not achieve

sustained response to standard combination therapy or

long-term pegylated interferon monotherapy had a high

rate of liver transplantation and liver-related death,

researchers reported in the August 2011 issue of Hepatology.

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PSI-7977 with Standard Therapy Produces 91% Sustained

ResponseThe experimental hepatitis C virus (HCV)

nucleotide analog polymerase inhibitor PSI-7977, used in

combination with pegylated interferon and ribavirin,

demonstrated a 12-week sustained virological response

rate of 91% for previously untreated genotype 1 chronic

hepatitis C patients in the ongoing PROTON trial.HALT-C

Finds High Rate of Liver-Related Death and Transplants

among Interferon Non-RespondersChronic hepatitis C

patients in the HALT-C study who did not achieve

sustained response to standard combination therapy or

long-term pegylated interferon monotherapy had a high

rate of liver transplantation and liver-related death,

researchers reported in the August 2011 issue of Hepatology.

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