Pregnancy outcomes associated with viral hepatitis

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2893.2011.01436.x/abstract

Pregnancy outcomes associated with viral hepatitis

K. L. B. Reddick1, R. Jhaveri2,3, M. Gandhi4,5, A. H. 1, G. K.

Swamy1Article first published online: 8 FEB 2011

DOI: 10.1111/j.1365-2893.2011.01436.x

© 2011 Blackwell Publishing Ltd

Issue

Journal of Viral Hepatitis

Early View (Articles online in advance of print)

Summary. 

The aim of this study was to examine the contribution of hepatitis B virus (HBV)

and hepatitis C virus (HCV) to pregnancy-related complications including

gestational diabetes mellitus (GDM), preterm birth (PTB), intrauterine growth

restriction (IUGR), pre-eclampsia, antepartum haemorrhage and cholestasis. The

Nationwide Inpatient Sample was queried for all pregnancy-related discharges,

pregnancy complications and viral hepatitis from 1995 to 2005. Logistic

regression was used to examine the association between HBV, HCV, HBV + HCV and

pregnancy-related complications including GDM, PTB, IUGR, pre-eclampsia,

antepartum haemorrhage, cholestasis and caesarean delivery. Model covariates

included maternal age, race, insurance status, substance use and medical

complications including liver complication, hypertension, HIV, anaemia,

thrombocytopenia and sexually transmitted infections. Of 297 664 pregnant women

data available for analysis, 1446 had a coded diagnosis of HBV, HCV or both.

High-risk behaviours, such as smoking, alcohol and substance use were higher in

women with either HBV or HCV. Women with HBV had an increased risk for PTB (aOR

1.65, CI [1.3, 2.0]) but a decreased risk for caesarean delivery (aOR 0.686, CI

[0.53, 0.88]). Individuals with HCV had an increased risk for GDM (aOR 1.6, CI

[1.0, 2.6]). Individuals with both HBV and HCV co-infection had an increased

risk for antepartum haemorrhage (aOR 2.82, CI [1.1, 7.2]). There was no

association of viral hepatitis with IUGR or pre-eclampsia. Women with hepatitis

have an increased risk for complications during pregnancy. Research to determine

the efficacy and cost-effectiveness of counselling patients about potential

risks for adverse outcomes is warranted.

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2893.2011.01436.x/abstract

Pregnancy outcomes associated with viral hepatitis

K. L. B. Reddick1, R. Jhaveri2,3, M. Gandhi4,5, A. H. 1, G. K.

Swamy1Article first published online: 8 FEB 2011

DOI: 10.1111/j.1365-2893.2011.01436.x

© 2011 Blackwell Publishing Ltd

Issue

Journal of Viral Hepatitis

Early View (Articles online in advance of print)

Summary. 

The aim of this study was to examine the contribution of hepatitis B virus (HBV)

and hepatitis C virus (HCV) to pregnancy-related complications including

gestational diabetes mellitus (GDM), preterm birth (PTB), intrauterine growth

restriction (IUGR), pre-eclampsia, antepartum haemorrhage and cholestasis. The

Nationwide Inpatient Sample was queried for all pregnancy-related discharges,

pregnancy complications and viral hepatitis from 1995 to 2005. Logistic

regression was used to examine the association between HBV, HCV, HBV + HCV and

pregnancy-related complications including GDM, PTB, IUGR, pre-eclampsia,

antepartum haemorrhage, cholestasis and caesarean delivery. Model covariates

included maternal age, race, insurance status, substance use and medical

complications including liver complication, hypertension, HIV, anaemia,

thrombocytopenia and sexually transmitted infections. Of 297 664 pregnant women

data available for analysis, 1446 had a coded diagnosis of HBV, HCV or both.

High-risk behaviours, such as smoking, alcohol and substance use were higher in

women with either HBV or HCV. Women with HBV had an increased risk for PTB (aOR

1.65, CI [1.3, 2.0]) but a decreased risk for caesarean delivery (aOR 0.686, CI

[0.53, 0.88]). Individuals with HCV had an increased risk for GDM (aOR 1.6, CI

[1.0, 2.6]). Individuals with both HBV and HCV co-infection had an increased

risk for antepartum haemorrhage (aOR 2.82, CI [1.1, 7.2]). There was no

association of viral hepatitis with IUGR or pre-eclampsia. Women with hepatitis

have an increased risk for complications during pregnancy. Research to determine

the efficacy and cost-effectiveness of counselling patients about potential

risks for adverse outcomes is warranted.