Drug-induced liver injury in a Swedish University hospital out-patient hepatolog

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Alimentary Pharmacology & Therapeutics

Volume 24 Page 1187 - October 2006

doi:10.1111/j.1365-2036.2006.03117.x

Volume 24 Issue 8

Drug-induced liver injury in a Swedish University hospital out-patient

hepatology clinic

M. B. DE VALLE, V. AV KLINTEBERG, N. ALEM, R. OLSSON & E. BJÖRNSSON

Summary

Background

Limited data exist on the proportion of drug-induced liver injury among

out-patients seen in a hepatology clinic.

Aim

To determine the proportion of drug-induced liver injury cases, and identify

the most important agents and the nature of the liver injury.

Methods

A computerized diagnoses database in an out-patient hepatology clinic in a

Swedish University hospital was analysed during the period 1995–2005. All

suspected drug-induced liver injury cases were causality assessed with the

International Consensus Criteria.

Results

A total of 1164 cases were seen for the first time during this period.

Drug-induced liver injury with at least a possible causal relationship was

found in 77 cases (6.6%), 38 (3.3%) of whom were referred for evaluation to

the out-patient clinic whereas 3% had a follow-up after hospitalization of

drug-induced liver injury. The median age was 58 years, 43 (56%) were

females, a hepatocellular pattern was observed in 37 cases (48%),

cholestatic in 31 (40%) and mixed in 12%. Antibiotics were the most common

agents causing drug-induced liver injury followed by non-steroidal

anti-inflammatory drugs, with diclofenac most often responsible for the

drug-induced liver injury.

Conclusions

Drug-induced liver injury cases constituted 6% of all out-patients and 3% of

referrals and occurred more often in women. Antibiotics and diclofenac were

the most common causes of drug-induced liver injury among out-patients.

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[Guest guest]

Alimentary Pharmacology & Therapeutics

Volume 24 Page 1187 - October 2006

doi:10.1111/j.1365-2036.2006.03117.x

Volume 24 Issue 8

Drug-induced liver injury in a Swedish University hospital out-patient

hepatology clinic

M. B. DE VALLE, V. AV KLINTEBERG, N. ALEM, R. OLSSON & E. BJÖRNSSON

Summary

Background

Limited data exist on the proportion of drug-induced liver injury among

out-patients seen in a hepatology clinic.

Aim

To determine the proportion of drug-induced liver injury cases, and identify

the most important agents and the nature of the liver injury.

Methods

A computerized diagnoses database in an out-patient hepatology clinic in a

Swedish University hospital was analysed during the period 1995–2005. All

suspected drug-induced liver injury cases were causality assessed with the

International Consensus Criteria.

Results

A total of 1164 cases were seen for the first time during this period.

Drug-induced liver injury with at least a possible causal relationship was

found in 77 cases (6.6%), 38 (3.3%) of whom were referred for evaluation to

the out-patient clinic whereas 3% had a follow-up after hospitalization of

drug-induced liver injury. The median age was 58 years, 43 (56%) were

females, a hepatocellular pattern was observed in 37 cases (48%),

cholestatic in 31 (40%) and mixed in 12%. Antibiotics were the most common

agents causing drug-induced liver injury followed by non-steroidal

anti-inflammatory drugs, with diclofenac most often responsible for the

drug-induced liver injury.

Conclusions

Drug-induced liver injury cases constituted 6% of all out-patients and 3% of

referrals and occurred more often in women. Antibiotics and diclofenac were

the most common causes of drug-induced liver injury among out-patients.

_________________________________________________________________

Share your special moments by uploading 500 photos per month to Windows Live

Spaces

http://clk.atdmt.com/MSN/go/msnnkwsp0070000001msn/direct/01/?href=http://www.get\

..live.com/spaces/features