Atypical Drugs Cause Atypical Syndromes

[Guest guest]

In a message dated 6/26/02 2:54:36 PM Mountain Daylight Time,

heather_buggy@... writes:

> They call this 'stiff man syndrome' or 'the frankenstein shuffle' in the

> so-called mental health community...my friend got it immediately after a

>

It's also called the Thorazine Two-Step and the Haldol Shuffle.

========

[Guest guest]

In a message dated 6/26/02 2:54:36 PM Mountain Daylight Time,

heather_buggy@... writes:

> They call this 'stiff man syndrome' or 'the frankenstein shuffle' in the

> so-called mental health community...my friend got it immediately after a

>

It's also called the Thorazine Two-Step and the Haldol Shuffle.

========

[Guest guest]

http://www.medscape.com/viewarticle/434458?srcmp=psy-062102 & WebLogicSession=PRnp\

zod7R7a5B1IuyTjDYC4KF18zw1oQ0N2rME0h9jLxPKQT6Ks5|-6279864661229444239/-140823335\

4/6/7001/7001/7002/7002/7001/-1

Atypical Neuroleptic Malignant Syndrome Associated With Olanzapine

Roy R. Reeves, D.O., Ph.D., Raphael A. , M.D., Liberto, M.D.,

Roy H. Hart, M.D.

Abstract and Introduction

Abstract

Neuroleptic malignant syndrome (NMS) is a potentially life-threatening

adverse effect of antipsychotic agents. It generally is characterized by

fever, altered mental status, rigidity, and autonomic dysfunction. A

53-year-old man developed NMS without rigidity while taking olanzapine. Such

atypical cases may support either a spectrum concept of NMS or the theory

that NMS secondary to atypical antipsychotics differs from that caused by

conventional neuroleptics. More flexible diagnostic criteria than currently

mandated by the the Diagnostic and Statistical Manual of Mental Disorders,

Fourth Revision, may be warranted.

Introduction

Neuroleptic malignant syndrome (NMS) is an uncommon side effect of

antipsychotic drugs, usually characterized by fever, altered mental status,

rigidity, and autonomic dysfunction. The pathophysiology of NMS is not fully

understood. Reduction in dopaminergic activity secondary to

neuroleptic-induced dopamine blockade is considered the chief mechanism.

This syndrome was first described in 1960 during clinical trials with

haloperidol. Since that time, NMS has been associated with virtually all

dopamine-blocking agents. Because many atypical antipsychotic agents have

weaker dopamine blockade and lower rates of extrapyramidal side effects than

conventional antipsychotic agents, it has been suggested that atypical

antipsychotic agents are less likely to cause NMS. However, this remains

unproven, and cases of NMS associated with clozapine, risperidone,

olanzapine, and quetiapine have been reported...

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[Guest guest]

http://www.medscape.com/viewarticle/434458?srcmp=psy-062102 & WebLogicSession=PRnp\

zod7R7a5B1IuyTjDYC4KF18zw1oQ0N2rME0h9jLxPKQT6Ks5|-6279864661229444239/-140823335\

4/6/7001/7001/7002/7002/7001/-1

Atypical Neuroleptic Malignant Syndrome Associated With Olanzapine

Roy R. Reeves, D.O., Ph.D., Raphael A. , M.D., Liberto, M.D.,

Roy H. Hart, M.D.

Abstract and Introduction

Abstract

Neuroleptic malignant syndrome (NMS) is a potentially life-threatening

adverse effect of antipsychotic agents. It generally is characterized by

fever, altered mental status, rigidity, and autonomic dysfunction. A

53-year-old man developed NMS without rigidity while taking olanzapine. Such

atypical cases may support either a spectrum concept of NMS or the theory

that NMS secondary to atypical antipsychotics differs from that caused by

conventional neuroleptics. More flexible diagnostic criteria than currently

mandated by the the Diagnostic and Statistical Manual of Mental Disorders,

Fourth Revision, may be warranted.

Introduction

Neuroleptic malignant syndrome (NMS) is an uncommon side effect of

antipsychotic drugs, usually characterized by fever, altered mental status,

rigidity, and autonomic dysfunction. The pathophysiology of NMS is not fully

understood. Reduction in dopaminergic activity secondary to

neuroleptic-induced dopamine blockade is considered the chief mechanism.

This syndrome was first described in 1960 during clinical trials with

haloperidol. Since that time, NMS has been associated with virtually all

dopamine-blocking agents. Because many atypical antipsychotic agents have

weaker dopamine blockade and lower rates of extrapyramidal side effects than

conventional antipsychotic agents, it has been suggested that atypical

antipsychotic agents are less likely to cause NMS. However, this remains

unproven, and cases of NMS associated with clozapine, risperidone,

olanzapine, and quetiapine have been reported...

_________________________________________________________________

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[Guest guest]

They call this 'stiff man syndrome' or 'the frankenstein shuffle' in the

so-called mental health community...my friend got it immediately after a

time release shot of risperodol...to say its uncommon is grossly

misleading...it is not atypical, hell, you can spy a person on

anti-psychotics a mile away, their bodies are frozen, like zombies...

>

>Atypical Neuroleptic Malignant Syndrome Associated With Olanzapine

>

>Roy R. Reeves, D.O., Ph.D., Raphael A. , M.D., Liberto, M.D.,

>Roy H. Hart, M.D.

>

>Abstract and Introduction

>Abstract

>Neuroleptic malignant syndrome (NMS) is a potentially life-threatening

>adverse effect of antipsychotic agents. It generally is characterized by

>fever, altered mental status, rigidity, and autonomic dysfunction. A

>53-year-old man developed NMS without rigidity while taking olanzapine.

>Such

>atypical cases may support either a spectrum concept of NMS or the theory

>that NMS secondary to atypical antipsychotics differs from that caused by

>conventional neuroleptics. More flexible diagnostic criteria than currently

>mandated by the the Diagnostic and Statistical Manual of Mental Disorders,

>Fourth Revision, may be warranted.

>

>Introduction

>Neuroleptic malignant syndrome (NMS) is an uncommon side effect of

>antipsychotic drugs, usually characterized by fever, altered mental status,

>rigidity, and autonomic dysfunction. The pathophysiology of NMS is not

>fully

>understood. Reduction in dopaminergic activity secondary to

>neuroleptic-induced dopamine blockade is considered the chief mechanism.

>This syndrome was first described in 1960 during clinical trials with

>haloperidol. Since that time, NMS has been associated with virtually all

>dopamine-blocking agents. Because many atypical antipsychotic agents have

>weaker dopamine blockade and lower rates of extrapyramidal side effects

>than

>conventional antipsychotic agents, it has been suggested that atypical

>antipsychotic agents are less likely to cause NMS. However, this remains

>unproven, and cases of NMS associated with clozapine, risperidone,

>olanzapine, and quetiapine have been reported...

>

>

>

>

>_________________________________________________________________

>Join the world’s largest e-mail service with MSN Hotmail.

>http://www.hotmail.com

>

>

_________________________________________________________________

Send and receive Hotmail on your mobile device: http://mobile.msn.com

[Guest guest]

They call this 'stiff man syndrome' or 'the frankenstein shuffle' in the

so-called mental health community...my friend got it immediately after a

time release shot of risperodol...to say its uncommon is grossly

misleading...it is not atypical, hell, you can spy a person on

anti-psychotics a mile away, their bodies are frozen, like zombies...

>

>Atypical Neuroleptic Malignant Syndrome Associated With Olanzapine

>

>Roy R. Reeves, D.O., Ph.D., Raphael A. , M.D., Liberto, M.D.,

>Roy H. Hart, M.D.

>

>Abstract and Introduction

>Abstract

>Neuroleptic malignant syndrome (NMS) is a potentially life-threatening

>adverse effect of antipsychotic agents. It generally is characterized by

>fever, altered mental status, rigidity, and autonomic dysfunction. A

>53-year-old man developed NMS without rigidity while taking olanzapine.

>Such

>atypical cases may support either a spectrum concept of NMS or the theory

>that NMS secondary to atypical antipsychotics differs from that caused by

>conventional neuroleptics. More flexible diagnostic criteria than currently

>mandated by the the Diagnostic and Statistical Manual of Mental Disorders,

>Fourth Revision, may be warranted.

>

>Introduction

>Neuroleptic malignant syndrome (NMS) is an uncommon side effect of

>antipsychotic drugs, usually characterized by fever, altered mental status,

>rigidity, and autonomic dysfunction. The pathophysiology of NMS is not

>fully

>understood. Reduction in dopaminergic activity secondary to

>neuroleptic-induced dopamine blockade is considered the chief mechanism.

>This syndrome was first described in 1960 during clinical trials with

>haloperidol. Since that time, NMS has been associated with virtually all

>dopamine-blocking agents. Because many atypical antipsychotic agents have

>weaker dopamine blockade and lower rates of extrapyramidal side effects

>than

>conventional antipsychotic agents, it has been suggested that atypical

>antipsychotic agents are less likely to cause NMS. However, this remains

>unproven, and cases of NMS associated with clozapine, risperidone,

>olanzapine, and quetiapine have been reported...

>

>

>

>

>_________________________________________________________________

>Join the world’s largest e-mail service with MSN Hotmail.

>http://www.hotmail.com

>

>

_________________________________________________________________

Send and receive Hotmail on your mobile device: http://mobile.msn.com

[Guest guest]

Is the thorazine two-step common even after quiting the drug?

My brother was prescribed thorazine (and artane) for a year when

hospitalized at 18. He's 50 now and I think he may very well have a

thorazine shuffle. His emotions are pretty flat too. His life says

a lot about the human spirit to be able to continue after going

through such shit.

> > They call this 'stiff man syndrome' or 'the frankenstein shuffle'

in the

> > so-called mental health community...my friend got it immediately

after a

> >

>

> It's also called the Thorazine Two-Step and the Haldol Shuffle.

> ========

[Guest guest]

Is the thorazine two-step common even after quiting the drug?

My brother was prescribed thorazine (and artane) for a year when

hospitalized at 18. He's 50 now and I think he may very well have a

thorazine shuffle. His emotions are pretty flat too. His life says

a lot about the human spirit to be able to continue after going

through such shit.

> > They call this 'stiff man syndrome' or 'the frankenstein shuffle'

in the

> > so-called mental health community...my friend got it immediately

after a

> >

>

> It's also called the Thorazine Two-Step and the Haldol Shuffle.

> ========