Treatment of chronic hepatitis B with recombinant leukocyte interferon and cyanidanol

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http://www.springerlink.com/content/82247g3874786q82/

Treatment of chronic hepatitis B with recombinant leukocyte interferon and

cyanidanol

Journal Journal of Gastroenterology

Publisher Springer Japan

ISSN 0944-1174 (Print) 1435-5922 (Online)

Issue Volume 23, Number 1 / February, 1988

Category Original Article

DOI 10.1007/BF02918855

PDF (645.4 KB)

Original Article

Treatment of chronic hepatitis B with recombinant leukocyte interferon and

cyanidanol

Koichi Kanai1 , Satoshi Morioka1, Takeyuki Nakajima1, Hidemasa Ishii1,

Katsutoshi Tamakoshi1, Hiroko Matsuda1, Masahiro Matsumoto1, Noriaki Mizushima1

and Yasunori Takehira1

(1) The Second Department of Medicine, University of Hamamatsu School of

Medicine, Handa-cho 3600, Hamamatsu, 431-31 Shizuoka, Japan

Received: 6 May 1987 Accepted: 14 September 1987

Summary Twelve male patients with chronic hepatitis B were treated by the

combination of recombinant human á-interferon and cyanidanol. They received 3

million units of interferon twice a week and 2,250 mg of cyanidanol daily for 24

weeks. Four patients had sustained clinical improvement in which hepatitis B e

antigen and DNA polymerase disappeared from sera and aminotransferase activities

fell to normal levels. Elevated pretreatment aminotransferases were associated

with the response to therapy. Also, decreased number of OKT4-positive cells

prior to treatment were observed among responders. Side effects were minimal and

all patients tolerated treatment on an outpatient basis.

Twice weekly administration of recombinant leukocyte interferon with cyanidanol

may be effective in treating chronic hepatitis when patients are appropriately

selected.

This work was supported in part by a grant for the prevention of viral hepatitis

from the Ministry of Health and Welfare of Japan.

_________________________________________________________________

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[Guest guest]

http://www.springerlink.com/content/82247g3874786q82/

Treatment of chronic hepatitis B with recombinant leukocyte interferon and

cyanidanol

Journal Journal of Gastroenterology

Publisher Springer Japan

ISSN 0944-1174 (Print) 1435-5922 (Online)

Issue Volume 23, Number 1 / February, 1988

Category Original Article

DOI 10.1007/BF02918855

PDF (645.4 KB)

Original Article

Treatment of chronic hepatitis B with recombinant leukocyte interferon and

cyanidanol

Koichi Kanai1 , Satoshi Morioka1, Takeyuki Nakajima1, Hidemasa Ishii1,

Katsutoshi Tamakoshi1, Hiroko Matsuda1, Masahiro Matsumoto1, Noriaki Mizushima1

and Yasunori Takehira1

(1) The Second Department of Medicine, University of Hamamatsu School of

Medicine, Handa-cho 3600, Hamamatsu, 431-31 Shizuoka, Japan

Received: 6 May 1987 Accepted: 14 September 1987

Summary Twelve male patients with chronic hepatitis B were treated by the

combination of recombinant human á-interferon and cyanidanol. They received 3

million units of interferon twice a week and 2,250 mg of cyanidanol daily for 24

weeks. Four patients had sustained clinical improvement in which hepatitis B e

antigen and DNA polymerase disappeared from sera and aminotransferase activities

fell to normal levels. Elevated pretreatment aminotransferases were associated

with the response to therapy. Also, decreased number of OKT4-positive cells

prior to treatment were observed among responders. Side effects were minimal and

all patients tolerated treatment on an outpatient basis.

Twice weekly administration of recombinant leukocyte interferon with cyanidanol

may be effective in treating chronic hepatitis when patients are appropriately

selected.

This work was supported in part by a grant for the prevention of viral hepatitis

from the Ministry of Health and Welfare of Japan.

_________________________________________________________________

Do more with your photos with Windows Live Photo Gallery.

http://www.windowslive.com/share.html?ocid=TXT_TAGLM_Wave2_photos_022008