Role of genotype and precore/basal core promoter mutations of hepatitis B virus in patients with chr

February 8, 2008

Role of genotype and precore/basal core promoter mutations of hepatitis B virus

in patients with chronic hepatitis B with acute exacerbation

Authors: Wei-Lun Tsai ab; Gin-Ho Lo ab; Ping-I Hsu ab; Kwok-Hung Lai ab;

Chiun-Ku Lin ab; Hoi-Hung Chan ab; Wen-Chi Chen ab; Jin-Shiung Cheng ab;

Yung-Ching Liu bc; Tsi-Shu Huang bc; Luo-Ping Ger d; Hsi-Hsun Lin e

Affiliations: a Division of Gastroenterology, Department of Internal

Medicine, Kaohsiung, Taiwan

b School of Medicine, National Yang Ming University, Taipei, Taiwan

c Division of Microbiology and Infectious Diseases, Department of Internal

Medicine, Kaohsiung, Taiwan

d Department of Research and Education, Kaohsiung Veterans General Hospital,

Kaohsiung, Taiwan

e Division of Microbiology and Infectious Diseases, E-Da Hospital, Kaohsiung,

Taiwan

DOI: 10.1080/00365520701745693

Publication Frequency: 12 issues per year

Published in: Scandinavian Journal of Gastroenterology, Volume 43, Issue 2 2008

, pages 196 - 201

Subjects: Gastroenterology; Gastrointestinal & Abdominal Surgery;

Formats available: HTML (English) : PDF (English)

Article Requests: Order Reprints : Request Permissions

Abstract

Objctive. The results of long-term, follow-up studies show that the severity and

frequency of acute exacerbation of chronic hepatitis B virus (HBV) are

associated with the development of liver cirrhosis in chronic HBV infection. The

aim of this study was to investigate the relationship between virological

factors of HBV and the severity of acute exacerbation. Material and methods.

Fifty-one chronic hepatitis B patients with symptomatic acute exacerbation

without antiviral therapy were enrolled in the study. Genotype of HBV was

determined by polymerase chain reaction-restriction fragment length polymorphism

(PCR-RFLP). Precore (A1896) and basal core promoter (BCP) mutations (T1762 &

A1764) were determined by PCR and direct sequencing. Results. Thirty-nine

patients had genotype B, 11 patients had genotype C, and 1 patient had an

unclassified genotype. Thirty-two patients had precore mutation and 24 patients

had BCP mutation. After adjusting for age, gender, aspartate aminotransferase

(ASAT) level, albumin level, and platelet count by multiple logistic regression

test, precore mutation had a protective effect on the occurrence of hepatic

decompensation (p=0.046), and genotype and BCP mutations were not associated

with the occurrence of hepatic decompensation. Conclusions. HBV precore mutation

may confer less severe liver disease during acute exacerbation of chronic HBV.

Genotype and BCP mutations did not have a significant association with the

occurrence of hepatic decompensation.

_________________________________________________________________

Climb to the top of the charts! Play the word scramble challenge with star

power.

February 8, 2008