Universal Hepatitis B Vaccination Reduces Childhood Hepatitis B Virus–Associated Membranous Nephropathy

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Universal Hepatitis B Vaccination Reduces Childhood Hepatitis B Virus–Associated

Membranous Nephropathy

Pediatrics, 09/09/2011

Liao MT et al. – These results revealed a significant decrease in the frequency

of hepatitis B virus (HBV)–associated membranous nephropathy (HBVMN) in children

with nephrotic syndrome (NS) and in long–term follow–up HBsAg carriers. Children

with HBVMN are primarily infected with HBV via horizontal transmission; thus,

the significant reduction in horizontal transmission in HBsAg–carrier children

in the general population after universal HBV vaccination may explain the

reduction of HBVMN in the vaccinated population.

Methods

• This study included 471 hospitalized children with nephrotic syndrome (NS) and

488 long-term follow-up hepatitis B surface antigen (HBsAg)-carrier children.

• Horizontal transmission (negative maternal HBsAg status) of HBVMN and HBV was

assessed, and the incidence of HBVMN was compared before and after initiation of

the universal HBV vaccination program started in 1984.

Results

• The frequency of HBVMN in children with NS was 11.6% between 1974 and 1984,

4.5% between 1984 and 1994, 2.1% between 1994 and 2004, and 0% between 2004 and

2009.

• Similarly, the number of HBsAg-seropositive children with NS (mainly via

horizontal infection) decreased after universal vaccination.

• The prevaccination frequency of HBV horizontal transmission in chronic HBsAg

carriers from the general population was 36.5% compared with 5% in the

postvaccination period.

• The incidence of HBVMN in these carriers revealed a parallel decline.

[Guest guest]

http://www.mdlinx.com/infectious-disease/newsl-article.cfm/3739603/ZZ68065536792\

5639220014/?news_id=497 & newsdt=090911 & subspec_id=130

Universal Hepatitis B Vaccination Reduces Childhood Hepatitis B Virus–Associated

Membranous Nephropathy

Pediatrics, 09/09/2011

Liao MT et al. – These results revealed a significant decrease in the frequency

of hepatitis B virus (HBV)–associated membranous nephropathy (HBVMN) in children

with nephrotic syndrome (NS) and in long–term follow–up HBsAg carriers. Children

with HBVMN are primarily infected with HBV via horizontal transmission; thus,

the significant reduction in horizontal transmission in HBsAg–carrier children

in the general population after universal HBV vaccination may explain the

reduction of HBVMN in the vaccinated population.

Methods

• This study included 471 hospitalized children with nephrotic syndrome (NS) and

488 long-term follow-up hepatitis B surface antigen (HBsAg)-carrier children.

• Horizontal transmission (negative maternal HBsAg status) of HBVMN and HBV was

assessed, and the incidence of HBVMN was compared before and after initiation of

the universal HBV vaccination program started in 1984.

Results

• The frequency of HBVMN in children with NS was 11.6% between 1974 and 1984,

4.5% between 1984 and 1994, 2.1% between 1994 and 2004, and 0% between 2004 and

2009.

• Similarly, the number of HBsAg-seropositive children with NS (mainly via

horizontal infection) decreased after universal vaccination.

• The prevaccination frequency of HBV horizontal transmission in chronic HBsAg

carriers from the general population was 36.5% compared with 5% in the

postvaccination period.

• The incidence of HBVMN in these carriers revealed a parallel decline.