Ethnogeographical structure of hepatitis B virus genotype distribution in Indonesia and discovery of a new subgenotype, B9

[Guest guest]

Arch Virol. 2011 Feb 12. [Epub ahead of print]

Ethnogeographical structure of hepatitis B virus genotype distribution in

Indonesia and discovery of a new subgenotype, B9.

Thedja MD, Muljono DH, Nurainy N, Sukowati CH, Verhoef J, Marzuki S.

Eijkman Institute for Molecular Biology, Jalan Diponegoro 69, Jakarta, 10430,

Indonesia.

Abstract

The distribution of hepatitis B virus (HBV) in the populations of island

Southeast Asia is of medical and anthropological interest and is associated with

an unusually high genetic diversity. This study examined the association of this

HBV genetic diversity with the ethnogeography of the populations of the

Indonesian archipelago. Whole genome analysis of 21 HBV isolates from East Nusa

Tenggara and Papua revealed two recently reported HBV/B subgenotypes unique to

the former, B7 (7 isolates) and B8 (5 isolates), and uncovered a further novel

subgenotype designated B9 (4 isolates). Further isolates were collected from 419

individuals with defined ethnic backgrounds representing 40 populations. HBV/B

was predominant in Austronesian-language-speaking populations, whereas HBV/C was

the major genotype in Papua and Papua-influenced populations of Moluccas; HBV/B3

was the predominant subgenotype in the western half of the archipelago (speakers

of the Western Malayo-Polynesian [WMP] branch of Austronesian languages),

whereas B7, B8 and B9 were specific to Nusa Tenggara (Central Malayo-Polynesian

(CMP)). The result provides the first direct evidence that the distribution of

HBV genotypes/subgenotypes in the Indonesian archipelago is related to the

ethnic origin of its populations and suggests that the HBV distribution is

associated with the ancient migratory events in the peopling of the archipelago.

PMID: 21318309 [PubMed - as supplied by publisher]

[Guest guest]

Arch Virol. 2011 Feb 12. [Epub ahead of print]

Ethnogeographical structure of hepatitis B virus genotype distribution in

Indonesia and discovery of a new subgenotype, B9.

Thedja MD, Muljono DH, Nurainy N, Sukowati CH, Verhoef J, Marzuki S.

Eijkman Institute for Molecular Biology, Jalan Diponegoro 69, Jakarta, 10430,

Indonesia.

Abstract

The distribution of hepatitis B virus (HBV) in the populations of island

Southeast Asia is of medical and anthropological interest and is associated with

an unusually high genetic diversity. This study examined the association of this

HBV genetic diversity with the ethnogeography of the populations of the

Indonesian archipelago. Whole genome analysis of 21 HBV isolates from East Nusa

Tenggara and Papua revealed two recently reported HBV/B subgenotypes unique to

the former, B7 (7 isolates) and B8 (5 isolates), and uncovered a further novel

subgenotype designated B9 (4 isolates). Further isolates were collected from 419

individuals with defined ethnic backgrounds representing 40 populations. HBV/B

was predominant in Austronesian-language-speaking populations, whereas HBV/C was

the major genotype in Papua and Papua-influenced populations of Moluccas; HBV/B3

was the predominant subgenotype in the western half of the archipelago (speakers

of the Western Malayo-Polynesian [WMP] branch of Austronesian languages),

whereas B7, B8 and B9 were specific to Nusa Tenggara (Central Malayo-Polynesian

(CMP)). The result provides the first direct evidence that the distribution of

HBV genotypes/subgenotypes in the Indonesian archipelago is related to the

ethnic origin of its populations and suggests that the HBV distribution is

associated with the ancient migratory events in the peopling of the archipelago.

PMID: 21318309 [PubMed - as supplied by publisher]