Serum markers for necroinflammatory activity in patients with chronic viral hepatitis and normal or mildly elevated aminotransferase levels

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Serum markers for necroinflammatory activity in patients with chronic viral

hepatitis and normal or mildly elevated aminotransferase levels

Liver International, 09/23/2011

Cheong JY et al. – The Aspartate aminotransferase(AST) and apolipoprotein A1

levels were shown to be independent predictors of significant inflammatory

activities in patients with chronic hepatitis B(CHB) and chronic hepatitis

C(CHC) and normal or mildly elevated aminotransferase levels.

Methods• 227 patients with CHB or CHC with normal or mildly elevated serum

alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels

(≤60IU/L) were enrolled in this study.

• Significant inflammation was defined as inflammatory grade ≥3 activities

using the Batt-Ludwig scoring system.

• Correlation between liver histology and serum markers of liver inflammation

was analysed.

Results

• 48 (21.1%) and eight patients (3.5%) had grade 3 and 4 inflammation

respectively.

• Univariate analysis revealed that age, platelet coun, and AST, ALT,

γ-glutamyl transpeptidase, alkaline phosphatase, hyaluronic acid, haptoglobin,

apolipoprotein A1 and procollagen III N-terminal peptide levels were

significantly different between the patients with and without significant

inflammation.

• There were no significant differences in the cytokeratin-18 fragment levels

between the two groups.

• On the basis of multivariate analysis, the AST and apolipoprotein A1 levels

and stage of fibrosis were highly predictive of significant inflammation.

• Using AST and apolipoprotein cut-off values ≥44IU/L and ≤100ng/ml,

respectively, the presence of significant inflammation was predicted with high

specificity (96.5%) and with a negative predictive value of 76.3%.

[Guest guest]

http://www.mdlinx.com/infectious-disease/newsl-article.cfm/3749763/ZZ68065536792\

5639220014/?news_id=497 & newsdt=092311 & subspec_id=130

Serum markers for necroinflammatory activity in patients with chronic viral

hepatitis and normal or mildly elevated aminotransferase levels

Liver International, 09/23/2011

Cheong JY et al. – The Aspartate aminotransferase(AST) and apolipoprotein A1

levels were shown to be independent predictors of significant inflammatory

activities in patients with chronic hepatitis B(CHB) and chronic hepatitis

C(CHC) and normal or mildly elevated aminotransferase levels.

Methods• 227 patients with CHB or CHC with normal or mildly elevated serum

alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels

(≤60IU/L) were enrolled in this study.

• Significant inflammation was defined as inflammatory grade ≥3 activities

using the Batt-Ludwig scoring system.

• Correlation between liver histology and serum markers of liver inflammation

was analysed.

Results

• 48 (21.1%) and eight patients (3.5%) had grade 3 and 4 inflammation

respectively.

• Univariate analysis revealed that age, platelet coun, and AST, ALT,

γ-glutamyl transpeptidase, alkaline phosphatase, hyaluronic acid, haptoglobin,

apolipoprotein A1 and procollagen III N-terminal peptide levels were

significantly different between the patients with and without significant

inflammation.

• There were no significant differences in the cytokeratin-18 fragment levels

between the two groups.

• On the basis of multivariate analysis, the AST and apolipoprotein A1 levels

and stage of fibrosis were highly predictive of significant inflammation.

• Using AST and apolipoprotein cut-off values ≥44IU/L and ≤100ng/ml,

respectively, the presence of significant inflammation was predicted with high

specificity (96.5%) and with a negative predictive value of 76.3%.