Tobacco and other factors have a negative impact on quality of life in hepatitis C patients

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http://www.ingentaconnect.com/content/bsc/jvh/2011/00000018/00000010/art00032

Journal of Viral Hepatitis, Volume 18, Number 10

Tobacco and other factors have a negative impact on quality of life in hepatitis

C patients

Authors: Yamini, D.; Basseri, B.; Chee, G. M.; Arakelyan, A.; Enayati, P.; Tran,

T. T.; Poordad, F.

Source: Journal of Viral Hepatitis, Volume 18, Number 10, 1 October 2011 , pp.

714-720(7)

Publisher: Wiley-Blackwell

Summary.  Hepatitis C virus (HCV) is known to adversely affect general,

social, emotional and mental health domains. This study was designed to identify

variables that may be associated with these measurable outcomes. We conducted a

cross-sectional retrospective review of demographic and clinical data from 800

patients with HCV evaluated between January 1998 and November 2007. Data were

collected using a standardized questionnaire filled out by the patients at the

first encounter. Variables evaluated included fibrosis stages (i.e. FS0/1/2 vs

FS3/4), demographics, comorbid health conditions, tobacco and alcohol use,

high-risk social behaviours and laboratory data. Variables assessed were

depression, fatigue, problems sleeping and loss of interest in sex. Statistical

analysis was performed using univariate and multivariate logistic regression.

Depression (29.3%) in our HCV study population was associated with female

gender, tobacco use, hyperlipidemia, history of heavy alcohol use and

intravenous drug use. Fatigue (44.6%) was associated with end-stage renal

disease, past and current tobacco use and current alcohol use. Difficulty

sleeping (13.8%) was associated with past and current tobacco use, current

alcohol use and diabetes. Loss of interest in sex (7.7%) was associated with

current tobacco use, multiple risk factors for HCV and age at time of

evaluation. Fibrosis stage (FS) also had a significant positive association with

alcohol use (OR 2.61; P = 0.003) and tobacco use (OR 2.00; P = 0.002).

Smoking and alcohol use have a significant negative impact on the presence of

depression, fatigue, difficulty sleeping and loss of interest in sex in HCV

patients. Practitioners should be aware of these associations, particularly

tobacco use, which significantly and negatively impacted every variable

evaluated.

Document Type: Research article

DOI: 10.1111/j.1365-2893.2010.01361.x

Affiliations:1: Hepatology Section, Division of Gastroenterology, Cedars-Sinai

Medical Center, Los Angeles, CA, USA

Publication date: 2011-10-01

[Guest guest]

http://www.ingentaconnect.com/content/bsc/jvh/2011/00000018/00000010/art00032

Journal of Viral Hepatitis, Volume 18, Number 10

Tobacco and other factors have a negative impact on quality of life in hepatitis

C patients

Authors: Yamini, D.; Basseri, B.; Chee, G. M.; Arakelyan, A.; Enayati, P.; Tran,

T. T.; Poordad, F.

Source: Journal of Viral Hepatitis, Volume 18, Number 10, 1 October 2011 , pp.

714-720(7)

Publisher: Wiley-Blackwell

Summary.  Hepatitis C virus (HCV) is known to adversely affect general,

social, emotional and mental health domains. This study was designed to identify

variables that may be associated with these measurable outcomes. We conducted a

cross-sectional retrospective review of demographic and clinical data from 800

patients with HCV evaluated between January 1998 and November 2007. Data were

collected using a standardized questionnaire filled out by the patients at the

first encounter. Variables evaluated included fibrosis stages (i.e. FS0/1/2 vs

FS3/4), demographics, comorbid health conditions, tobacco and alcohol use,

high-risk social behaviours and laboratory data. Variables assessed were

depression, fatigue, problems sleeping and loss of interest in sex. Statistical

analysis was performed using univariate and multivariate logistic regression.

Depression (29.3%) in our HCV study population was associated with female

gender, tobacco use, hyperlipidemia, history of heavy alcohol use and

intravenous drug use. Fatigue (44.6%) was associated with end-stage renal

disease, past and current tobacco use and current alcohol use. Difficulty

sleeping (13.8%) was associated with past and current tobacco use, current

alcohol use and diabetes. Loss of interest in sex (7.7%) was associated with

current tobacco use, multiple risk factors for HCV and age at time of

evaluation. Fibrosis stage (FS) also had a significant positive association with

alcohol use (OR 2.61; P = 0.003) and tobacco use (OR 2.00; P = 0.002).

Smoking and alcohol use have a significant negative impact on the presence of

depression, fatigue, difficulty sleeping and loss of interest in sex in HCV

patients. Practitioners should be aware of these associations, particularly

tobacco use, which significantly and negatively impacted every variable

evaluated.

Document Type: Research article

DOI: 10.1111/j.1365-2893.2010.01361.x

Affiliations:1: Hepatology Section, Division of Gastroenterology, Cedars-Sinai

Medical Center, Los Angeles, CA, USA

Publication date: 2011-10-01