Emerging Issues in Hepatitis C Virus-Positive Liver and Kidney Transplant Recipi

[Guest guest]

American Journal of Transplantation

Volume 6 Page 2232 - October 2006

doi:10.1111/j.1600-6143.2006.01457.x

Volume 6 Issue 10

Minireview

Emerging Issues in Hepatitis C Virus-Positive Liver and Kidney Transplant

Recipients

R. D. Blooma,* and J. R. Lakeb

Hepatitis C virus (HCV) infection is a major health care issue in liver and

kidney transplantation. Besides negatively affecting both patient and graft

survival, HCV is associated with a heightened risk for new onset diabetes

mellitus (NODM). The mechanisms underlying the diabetogenicity of HCV are

complex but are likely to involve insulin resistance caused by inhibitory

actions of the virus on insulin regulatory pathways in the liver. The

resultant glucose dysregulation is an important determinant of increased

morbidity and mortality in liver and kidney recipients. This review

highlights the concerns for outcomes in HCV-positive liver and kidney

transplant patients with particular focus on the interrelationship between

hepatitis C and diabetes. Data about the potential role of calcineurin

inhibitors, corticosteroids and mycophenolate mofetil in HCV infection and

HCV-associated NODM will also be discussed.

_________________________________________________________________

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[Guest guest]

American Journal of Transplantation

Volume 6 Page 2232 - October 2006

doi:10.1111/j.1600-6143.2006.01457.x

Volume 6 Issue 10

Minireview

Emerging Issues in Hepatitis C Virus-Positive Liver and Kidney Transplant

Recipients

R. D. Blooma,* and J. R. Lakeb

Hepatitis C virus (HCV) infection is a major health care issue in liver and

kidney transplantation. Besides negatively affecting both patient and graft

survival, HCV is associated with a heightened risk for new onset diabetes

mellitus (NODM). The mechanisms underlying the diabetogenicity of HCV are

complex but are likely to involve insulin resistance caused by inhibitory

actions of the virus on insulin regulatory pathways in the liver. The

resultant glucose dysregulation is an important determinant of increased

morbidity and mortality in liver and kidney recipients. This review

highlights the concerns for outcomes in HCV-positive liver and kidney

transplant patients with particular focus on the interrelationship between

hepatitis C and diabetes. Data about the potential role of calcineurin

inhibitors, corticosteroids and mycophenolate mofetil in HCV infection and

HCV-associated NODM will also be discussed.

_________________________________________________________________

Windows Live Spaces is here! It’s easy to create your own personal Web site.

http://spaces.live.com/signup.aspx