Pantoprazole Induces Severe Acute Hepatitis.

[Guest guest]

Z Gastroenterol. 2011 Feb;49(2):207-210. Epub 2011 Feb 4.

Pantoprazole Induces Severe Acute Hepatitis.

Sandig C, Flechtenmacher C, Stremmel W, Eisenbach C.

Department of Gastroenterology and Hepatology, University Hospital of

Heidelberg, Heidelberg, Germany.

Abstract

A female patient receiving pantoprazole during a corticosteroid therapy for

encephalomyelitis disseminata developed severe acute hepatitis one month after

initiation of pantoprazole treatment. Other causes of hepatic dysfunction

including viral hepatitis, autoimmune hepatitis, primary sclerosing cholangitis,

primary biliary cirrhosis, haemochromatosis or 's disease were excluded.

Liver biopsy showed severe hepatic lesions with extensive necroses of the

parenchyma. One week after discontinuation of pantoprazole the liver function

began to improve and gradually the patient fully recovered. One year earlier the

patient had been treated with pantoprazole before and had developed a milder

form of hepatitis then. This case argues for an idiosyncratic hepatocellular

damage caused by pantoprazole.

© Georg Thieme Verlag KG Stuttgart · New York.

PMID: 21298607 [PubMed - as supplied by publisher]

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*(Brand name: Protonix)

Pantoprazole is used to treat gastroesophageal reflux disease (GERD), a

condition in which backward flow of acid from the stomach causes heartburn and

injury of the food pipe (esophagus). It is also used to treat conditions where

the stomach produces too much acid, such as Zollinger-Ellison syndrome.

www.nlm.nih.gov

â–ºPantoprazole - Wikipedia, the free encyclopedia Pantoprazole (sold under

various brand names including Pantoloc, Protium, Pantecta and Protonix) is a

proton pump inhibitor drug that inhibits gastric acid

[Guest guest]

Z Gastroenterol. 2011 Feb;49(2):207-210. Epub 2011 Feb 4.

Pantoprazole Induces Severe Acute Hepatitis.

Sandig C, Flechtenmacher C, Stremmel W, Eisenbach C.

Department of Gastroenterology and Hepatology, University Hospital of

Heidelberg, Heidelberg, Germany.

Abstract

A female patient receiving pantoprazole during a corticosteroid therapy for

encephalomyelitis disseminata developed severe acute hepatitis one month after

initiation of pantoprazole treatment. Other causes of hepatic dysfunction

including viral hepatitis, autoimmune hepatitis, primary sclerosing cholangitis,

primary biliary cirrhosis, haemochromatosis or 's disease were excluded.

Liver biopsy showed severe hepatic lesions with extensive necroses of the

parenchyma. One week after discontinuation of pantoprazole the liver function

began to improve and gradually the patient fully recovered. One year earlier the

patient had been treated with pantoprazole before and had developed a milder

form of hepatitis then. This case argues for an idiosyncratic hepatocellular

damage caused by pantoprazole.

© Georg Thieme Verlag KG Stuttgart · New York.

PMID: 21298607 [PubMed - as supplied by publisher]

---------------------------------------------------

*(Brand name: Protonix)

Pantoprazole is used to treat gastroesophageal reflux disease (GERD), a

condition in which backward flow of acid from the stomach causes heartburn and

injury of the food pipe (esophagus). It is also used to treat conditions where

the stomach produces too much acid, such as Zollinger-Ellison syndrome.

www.nlm.nih.gov

â–ºPantoprazole - Wikipedia, the free encyclopedia Pantoprazole (sold under

various brand names including Pantoloc, Protium, Pantecta and Protonix) is a

proton pump inhibitor drug that inhibits gastric acid