[SPAM] Re: Bird flu vaccine grown in monkey cells, not eggs, shows promising results

[Guest guest]

Any excuse to make the vaccine makers money! No proof that we

actually need this vaccine! Bush and his cohorts must sit around and

think of what new vaccines they can make us sick with next! There

wikl never be any pandemic unless they cause it themselves. They just

want to scare people into submitting to more vaccines.

> > > Bird flu vaccine grown in monkey cells, not eggs, shows

promising

> > results

> > >

> > > ________________________________

> > >

> > > Module body

> > > Wed Jun 11, 7:44 PM

> > > By Helen Branswell, Medical Reporter, The Canadian Press

> > > TORONTO - An avian flu vaccine grown in kidney cells from

African

> > green monkeys instead of eggs triggered a good immune response

at a

> > relatively low dose, according to a new study that highlights

the

> > promise of so-called cell culture vaccine production.

> > > Baxter Bioscience has already applied to the European vaccine

> > regulatory body for a licence for the product, the first H5N1

> vaccine

> > made in cell culture.

> > > The study and an accompanying perspective piece published in

> > Thursday's New England Journal of Medicine, hail the technique -

> seen

> > as the way of the future for flu vaccine production - as an

> important

> > time saver during a pandemic.

> > > Baxter suggests it could have first batches of vaccine ready

> within

> > 12 weeks of the start of a pandemic, not the 20 to 28 weeks

needed

> > for H5N1 vaccine made using traditional manufacturing

processes.

> > > " Are we prepared for pandemic influenza? We are not (yet)

ready

> to

> > put a vaccine in the field should H5 gain person-to-person

> > transmissibility or should another strain emerge, " Dr.

> ,

> > a pediatrician and influenza expert at Dartmouth Medical School

in

> > Hanover, N.H. wrote in the perspective article.

> > > " The work on novel vaccine approaches (such as cell culture),

> > however, suggests that we may still make it, if influenza

continues

> > to stay in its lair and largely confine itself to avian hosts, "

> added

> > , who was not involved in the research but who has

received

> > grant support from two other flu vaccine makers,

GlaxoKline

> and

> > MedImmune.

> > > Baxter's study found that two doses of either 7.5 micrograms

or

> 15

> > micrograms of vaccine induced a protective response without an

> > adjuvant - a chemical that boosts the immune response to the

> vaccine.

> > Many other vaccine makers are planning to use an adjuvant in

their

> > pandemic vaccines.

> > > The findings are based on two clinical trials in Austria and

in

> > Singapore. A total of 275 people received differing sized doses

of

> > the vaccine.

> > > Dr. Hartmut Ehrlich, lead author on the study, said Baxter

will

> > test lower doses - as low as 1.9 micrograms - in a followup

study

> in

> > the United States set to start this fall.

> > > Experts noted, though, that the Baxter study used a

different -

> and

> > lower - measure as being indicative of protection. Lowering the

bar

> > in this way may have made their results look better than they

would

> > have if they'd used the same standard as other companies have

used.

> > That higher standard is also used for regulatory purposes by

the

> U.S.

> > Food and Drug Administration.

> > > But Ehrlich, who is head of global research and development

for

> > Baxter's bioscience division, said the company is convinced the

> lower

> > measure would equate to protection. Baxter is in negotiations

with

> > the FDA on the issue, he said.

> > > " I think there is consensus at this point in time that there

is a

> > lot of room to learn for all parties, " Ehrlich said in an

> interview.

> > > Experts not involved in the research cautioned that Baxter's

> > positive results may not translate into a huge leap forward for

the

> > entire industry or for the effort to make enough product to

> vaccinate

> > billions of people early enough in a pandemic to make a

difference.

> > > For one thing, Baxter is a new player in flu vaccine,

building

> cell

> > culture production facilities from the get-go.

> > > Longtime vaccine manufacturers - whose seasonal flu

production

> > lines are based on growing vaccine viruses in hen's eggs - are

> > exploring the potential of cell culture too. Novartis, for

example,

> > makes a seasonal flu vaccine in cell culture for the European

> market.

> > > But for most of them - and they make the bulk of the world's

flu

> > vaccine - switching over to cell culture production will

involve

> > significant investment and regulatory hurdles.

> > > " It's not that they couldn't do it, but they'd have to change

> their

> > process, " said Dr. Treanor, an influenza vaccine expert at

the

> > University of Rochester in northern New York State.

> > > As well, the Baxter vaccine is made with whole, unmodified

H5N1

> > viruses. (The viruses are killed in the production process,

making

> > them safe to inject into humans.)

> > > Whole virus vaccine is generally thought to induce a stronger

> > immune response than the industry standard made from viruses

split

> in

> > a purification process. And in this study, it appeared to

produce a

> > response that was cross protective as well; the vaccine, made

with

> a

> > 2004 virus from Vietnam, also seemed to protect against a 1997

H5N1

> > virus and one from Indonesia in 2005.

> > > But previous experience with whole virus vaccines showed they

> also

> > induce more reactions - sore arms, headaches and malaise -

which is

> > one reason why current manufacturers don't make whole virus

> seasonal

> > flu vaccine. Switching over would require changes to production

> > lines, Treanor noted.

> > > " From a scientific point of view I think we are in a scenario

now

> > where there are many different ... alternative strategies that

you

> > could use and it's really not clear how much of an advantage

one

> > might have over another, " he said.

> > > And even though cell culture production offers the

possibility of

> > making much more vaccine more quickly, downstream problems

would

> > create bottlenecks, said Dr. Osterholm, director of the

> > Center for Infectious Diseases Research and Policy at the

> University

> > of Minnesota.

> > > Ramping up production requires additional capacity to bottle

> > vaccine. Mass vaccination requires the capacity to ship and

> deliver,

> > all the while keeping the vaccine cold. And it requires trained

> > people to inject the vaccine and syringes for the injections.

> > > " This is to me like fixing the engine on your car and

> saying 'We're

> > making great improvements' but forgetting about the brakes and

> > steering, " Osterholm said.

> > > " You've got to have the whole package to make the vehicle

work. "

> > > Bird Flu

> > > LATEST HEADLINES

> > > * WHO says Indonesia has given assurances it will report bird

> > flu cases The Canadian Press

> > > * Bird flu vaccine grown in monkey cells, not eggs, shows

> > promising results The Canadian Press

> > > * Hong Kong culls all live poultry in markets after bird flu

> > outbreak AFP

> > > * Hong Kong bans mainland poultry after bird flu outbreak AFP

> > > * Indonesian health minister silent on bird flu toll AFP

> > >

> > > Health

> > > LATEST HEADLINES

> > > * Salmonella-tainted tomato illnesses reach 228 in United

> > States The Canadian Press

> > > * Guelph scientist testing technique to inoculate tomatoes

> > against salmonella The Canadian Press

> > > * Alberta joins other provinces in approving HPV vaccine for

> > teens, young women The Canadian Press

> > > * WHO says Indonesia has given assurances it will report bird

> > flu cases The Canadian Press

> > > * Health News Archive

> > > Most Popular

> > > MOST RECOMMENDED

> > > * 52

> > > New York mother finds snake in crib, coiled around baby's leg

> > > * » View Most Popular

> > > * » Submit a Story link

> > > News Video

> > > * Rocking Out With the Jonas Brothers ABC

> > > * NBC's Tim Russert dies aged 58 BBC

> > > * Blair dodges question on US vote Reuters

> > > * Alleged gas price fixing frustrates Montreal motorists

> > Canadian Press

> > > Y! CANADA LOCAL NEWS

> > > Coast to Coast

> > > The latest headlines from your city

> > > » Choose your city

> > > IN THE NEWS

> > >

> > > Fuming

> > > Gas market reacts to price-fixing charges

> > > » In Pictures: Oil & Gas

> > >

> > > Historic Ruling

> > > Guantanamo ruling deals blow to Bush

> > > » More U.S. News

> > >

> > > New Deal

> > > , Google in online ad alliance

> > > » Microsoft takeover talks end

> > > Slideshows

> > > * European Union

> > > * NASA Shuttle

> > > * Heigl

> > > * Apple iPhone

> > > * Euro 2008

> > > * Mike Myers

> > > In Depth

> > > * Economy

> > > * Soccer

> > > * U.S. Election

> > > * Internet News

> > > * Beijing Olympics

> > > * Royal Family

> > > BACK TO TOP

> > >

> > > ________________________________

> > >

> > > Search: Advanced

> > > Primary Navigation

> > > * News Home

> > > * Canada

> > > * U.S.

> > > * World

> > > * Business

> > > * Entertainment

> > > * Sports

> > > * Health

> > > * Tech

> > > * Odd News

> > > * In Depth

> > > * Most Popular

> > > Canadian Press

> > > Canada Co. .

Privacy

> > Policy - Terms of Service

> > > Community Guidelines - Privacy Guidelines

> > > Need help? Want to send feedback?

> > >

> > > llDarkAngelxl

> > >

> > > ~ WANTED - Canadian Patriots to Help Save Canada Now!

> > > Recruiting Candidates (18 yrs and up) and Campaign Volunteers

(no

> > age restriction) for Next Federal Election - send your resume

and

> > cover letter to CAP President at cathpublish@

wildroseinternet .ca

> > > http://stopspp. com/stopspp/ ?cat=20

> > > http://www.oasisadv ancedwellness. com/learning/ vaccination-

> > exemption. html

> > > http://www.jonesrep ort.com/

> > > Visit My Blog // Profile

> > > http://360.. ca/AngelOFSighte d.Darkness

> > >

> >

>

[Guest guest]

Any excuse to make the vaccine makers money! No proof that we

actually need this vaccine! Bush and his cohorts must sit around and

think of what new vaccines they can make us sick with next! There

wikl never be any pandemic unless they cause it themselves. They just

want to scare people into submitting to more vaccines.

> > > Bird flu vaccine grown in monkey cells, not eggs, shows

promising

> > results

> > >

> > > ________________________________

> > >

> > > Module body

> > > Wed Jun 11, 7:44 PM

> > > By Helen Branswell, Medical Reporter, The Canadian Press

> > > TORONTO - An avian flu vaccine grown in kidney cells from

African

> > green monkeys instead of eggs triggered a good immune response

at a

> > relatively low dose, according to a new study that highlights

the

> > promise of so-called cell culture vaccine production.

> > > Baxter Bioscience has already applied to the European vaccine

> > regulatory body for a licence for the product, the first H5N1

> vaccine

> > made in cell culture.

> > > The study and an accompanying perspective piece published in

> > Thursday's New England Journal of Medicine, hail the technique -

> seen

> > as the way of the future for flu vaccine production - as an

> important

> > time saver during a pandemic.

> > > Baxter suggests it could have first batches of vaccine ready

> within

> > 12 weeks of the start of a pandemic, not the 20 to 28 weeks

needed

> > for H5N1 vaccine made using traditional manufacturing

processes.

> > > " Are we prepared for pandemic influenza? We are not (yet)

ready

> to

> > put a vaccine in the field should H5 gain person-to-person

> > transmissibility or should another strain emerge, " Dr.

> ,

> > a pediatrician and influenza expert at Dartmouth Medical School

in

> > Hanover, N.H. wrote in the perspective article.

> > > " The work on novel vaccine approaches (such as cell culture),

> > however, suggests that we may still make it, if influenza

continues

> > to stay in its lair and largely confine itself to avian hosts, "

> added

> > , who was not involved in the research but who has

received

> > grant support from two other flu vaccine makers,

GlaxoKline

> and

> > MedImmune.

> > > Baxter's study found that two doses of either 7.5 micrograms

or

> 15

> > micrograms of vaccine induced a protective response without an

> > adjuvant - a chemical that boosts the immune response to the

> vaccine.

> > Many other vaccine makers are planning to use an adjuvant in

their

> > pandemic vaccines.

> > > The findings are based on two clinical trials in Austria and

in

> > Singapore. A total of 275 people received differing sized doses

of

> > the vaccine.

> > > Dr. Hartmut Ehrlich, lead author on the study, said Baxter

will

> > test lower doses - as low as 1.9 micrograms - in a followup

study

> in

> > the United States set to start this fall.

> > > Experts noted, though, that the Baxter study used a

different -

> and

> > lower - measure as being indicative of protection. Lowering the

bar

> > in this way may have made their results look better than they

would

> > have if they'd used the same standard as other companies have

used.

> > That higher standard is also used for regulatory purposes by

the

> U.S.

> > Food and Drug Administration.

> > > But Ehrlich, who is head of global research and development

for

> > Baxter's bioscience division, said the company is convinced the

> lower

> > measure would equate to protection. Baxter is in negotiations

with

> > the FDA on the issue, he said.

> > > " I think there is consensus at this point in time that there

is a

> > lot of room to learn for all parties, " Ehrlich said in an

> interview.

> > > Experts not involved in the research cautioned that Baxter's

> > positive results may not translate into a huge leap forward for

the

> > entire industry or for the effort to make enough product to

> vaccinate

> > billions of people early enough in a pandemic to make a

difference.

> > > For one thing, Baxter is a new player in flu vaccine,

building

> cell

> > culture production facilities from the get-go.

> > > Longtime vaccine manufacturers - whose seasonal flu

production

> > lines are based on growing vaccine viruses in hen's eggs - are

> > exploring the potential of cell culture too. Novartis, for

example,

> > makes a seasonal flu vaccine in cell culture for the European

> market.

> > > But for most of them - and they make the bulk of the world's

flu

> > vaccine - switching over to cell culture production will

involve

> > significant investment and regulatory hurdles.

> > > " It's not that they couldn't do it, but they'd have to change

> their

> > process, " said Dr. Treanor, an influenza vaccine expert at

the

> > University of Rochester in northern New York State.

> > > As well, the Baxter vaccine is made with whole, unmodified

H5N1

> > viruses. (The viruses are killed in the production process,

making

> > them safe to inject into humans.)

> > > Whole virus vaccine is generally thought to induce a stronger

> > immune response than the industry standard made from viruses

split

> in

> > a purification process. And in this study, it appeared to

produce a

> > response that was cross protective as well; the vaccine, made

with

> a

> > 2004 virus from Vietnam, also seemed to protect against a 1997

H5N1

> > virus and one from Indonesia in 2005.

> > > But previous experience with whole virus vaccines showed they

> also

> > induce more reactions - sore arms, headaches and malaise -

which is

> > one reason why current manufacturers don't make whole virus

> seasonal

> > flu vaccine. Switching over would require changes to production

> > lines, Treanor noted.

> > > " From a scientific point of view I think we are in a scenario

now

> > where there are many different ... alternative strategies that

you

> > could use and it's really not clear how much of an advantage

one

> > might have over another, " he said.

> > > And even though cell culture production offers the

possibility of

> > making much more vaccine more quickly, downstream problems

would

> > create bottlenecks, said Dr. Osterholm, director of the

> > Center for Infectious Diseases Research and Policy at the

> University

> > of Minnesota.

> > > Ramping up production requires additional capacity to bottle

> > vaccine. Mass vaccination requires the capacity to ship and

> deliver,

> > all the while keeping the vaccine cold. And it requires trained

> > people to inject the vaccine and syringes for the injections.

> > > " This is to me like fixing the engine on your car and

> saying 'We're

> > making great improvements' but forgetting about the brakes and

> > steering, " Osterholm said.

> > > " You've got to have the whole package to make the vehicle

work. "

> > > Bird Flu

> > > LATEST HEADLINES

> > > * WHO says Indonesia has given assurances it will report bird

> > flu cases The Canadian Press

> > > * Bird flu vaccine grown in monkey cells, not eggs, shows

> > promising results The Canadian Press

> > > * Hong Kong culls all live poultry in markets after bird flu

> > outbreak AFP

> > > * Hong Kong bans mainland poultry after bird flu outbreak AFP

> > > * Indonesian health minister silent on bird flu toll AFP

> > >

> > > Health

> > > LATEST HEADLINES

> > > * Salmonella-tainted tomato illnesses reach 228 in United

> > States The Canadian Press

> > > * Guelph scientist testing technique to inoculate tomatoes

> > against salmonella The Canadian Press

> > > * Alberta joins other provinces in approving HPV vaccine for

> > teens, young women The Canadian Press

> > > * WHO says Indonesia has given assurances it will report bird

> > flu cases The Canadian Press

> > > * Health News Archive

> > > Most Popular

> > > MOST RECOMMENDED

> > > * 52

> > > New York mother finds snake in crib, coiled around baby's leg

> > > * » View Most Popular

> > > * » Submit a Story link

> > > News Video

> > > * Rocking Out With the Jonas Brothers ABC

> > > * NBC's Tim Russert dies aged 58 BBC

> > > * Blair dodges question on US vote Reuters

> > > * Alleged gas price fixing frustrates Montreal motorists

> > Canadian Press

> > > Y! CANADA LOCAL NEWS

> > > Coast to Coast

> > > The latest headlines from your city

> > > » Choose your city

> > > IN THE NEWS

> > >

> > > Fuming

> > > Gas market reacts to price-fixing charges

> > > » In Pictures: Oil & Gas

> > >

> > > Historic Ruling

> > > Guantanamo ruling deals blow to Bush

> > > » More U.S. News

> > >

> > > New Deal

> > > , Google in online ad alliance

> > > » Microsoft takeover talks end

> > > Slideshows

> > > * European Union

> > > * NASA Shuttle

> > > * Heigl

> > > * Apple iPhone

> > > * Euro 2008

> > > * Mike Myers

> > > In Depth

> > > * Economy

> > > * Soccer

> > > * U.S. Election

> > > * Internet News

> > > * Beijing Olympics

> > > * Royal Family

> > > BACK TO TOP

> > >

> > > ________________________________

> > >

> > > Search: Advanced

> > > Primary Navigation

> > > * News Home

> > > * Canada

> > > * U.S.

> > > * World

> > > * Business

> > > * Entertainment

> > > * Sports

> > > * Health

> > > * Tech

> > > * Odd News

> > > * In Depth

> > > * Most Popular

> > > Canadian Press

> > > Canada Co. .

Privacy

> > Policy - Terms of Service

> > > Community Guidelines - Privacy Guidelines

> > > Need help? Want to send feedback?

> > >

> > > llDarkAngelxl

> > >

> > > ~ WANTED - Canadian Patriots to Help Save Canada Now!

> > > Recruiting Candidates (18 yrs and up) and Campaign Volunteers

(no

> > age restriction) for Next Federal Election - send your resume

and

> > cover letter to CAP President at cathpublish@

wildroseinternet .ca

> > > http://stopspp. com/stopspp/ ?cat=20

> > > http://www.oasisadv ancedwellness. com/learning/ vaccination-

> > exemption. html

> > > http://www.jonesrep ort.com/

> > > Visit My Blog // Profile

> > > http://360.. ca/AngelOFSighte d.Darkness

> > >

> >

>