Diagnosis and quantification of hepatic fibrosis in children with diffusion weighted MR imaging

[Guest guest]

http://www.ejradiology.com/article/PIIS0720048X09005762/abstract?rss=yes

EUROPEAN JOURNAL OF RADIOLOGY

Volume 78, Issue 1, Pages 129-134 (April 2011)

Diagnosis and quantification of hepatic fibrosis in children with diffusion

weighted MR imaging

Presented as oral presentation at RSNA2008

Ahmed Abdel Khalek Abdel Razeka, Ahmed Abdallab, Eman Omrana, Abeer Fathyb,

Khaled Zalatac

Received 25 July 2009; received in revised form 8 October 2009; accepted 9

October 2009.

Abstract

Purpose

To evaluate the accuracy of diffusion weighted MR imaging in diagnosis and

quantification of hepatic fibrosis in children with chronic hepatitis.

Materials and methods

Sixty-three consecutive children (40 boys, 23 girls, median age 9.3 years), with

chronic hepatitis and thirty age matched volunteers underwent diffusion weighted

MR imaging of the liver using a single shot echoplanar imaging with b-value=0,

250, and 500s/mm2. Liver biopsy was obtained with calculation of METAVIR score.

The ADC value of the liver was correlated with METAVIR score. Receiver operating

characteristic curve was done for diagnosis and grading of hepatic fibrosis.

Results

There was statistical difference in the mean ADC value between volunteers and

patients with hepatic fibrosis (P=0.001) and in patients with different grades

of METAVIR scores (P=0.002). There was correlation between the mean ADC value

and METAVIR score (r=0.807, P=0.001). The cut off point to predict fibrosis

(1.7×10−3mm2/s) revealed 83% accuracy, 85% sensitivity, 82% specificity, 83%

PPV, and 85% NPV. The area under the curve was 0.91 for F1, 0.85 for F2, 0.86

for F3 and 0.90 for F4.

Conclusion

The apparent diffusion coefficient value is a promising quantitative parameter

used for diagnosis and quantification of hepatic fibrosis in children with

chronic hepatitis.

a Diagnostic Radiology Department, Mansoura Faculty of Medicine, 62 ElNokrasi

Street Meet Hadr, Mansoura 3512, Egypt

b Pediatric Department, Mansoura Faculty of Medicine, Mansoura, Egypt

c Diagnostic Pathology Department, Mansoura Faculty of Medicine, Mansoura, Egypt

[Guest guest]

http://www.ejradiology.com/article/PIIS0720048X09005762/abstract?rss=yes

EUROPEAN JOURNAL OF RADIOLOGY

Volume 78, Issue 1, Pages 129-134 (April 2011)

Diagnosis and quantification of hepatic fibrosis in children with diffusion

weighted MR imaging

Presented as oral presentation at RSNA2008

Ahmed Abdel Khalek Abdel Razeka, Ahmed Abdallab, Eman Omrana, Abeer Fathyb,

Khaled Zalatac

Received 25 July 2009; received in revised form 8 October 2009; accepted 9

October 2009.

Abstract

Purpose

To evaluate the accuracy of diffusion weighted MR imaging in diagnosis and

quantification of hepatic fibrosis in children with chronic hepatitis.

Materials and methods

Sixty-three consecutive children (40 boys, 23 girls, median age 9.3 years), with

chronic hepatitis and thirty age matched volunteers underwent diffusion weighted

MR imaging of the liver using a single shot echoplanar imaging with b-value=0,

250, and 500s/mm2. Liver biopsy was obtained with calculation of METAVIR score.

The ADC value of the liver was correlated with METAVIR score. Receiver operating

characteristic curve was done for diagnosis and grading of hepatic fibrosis.

Results

There was statistical difference in the mean ADC value between volunteers and

patients with hepatic fibrosis (P=0.001) and in patients with different grades

of METAVIR scores (P=0.002). There was correlation between the mean ADC value

and METAVIR score (r=0.807, P=0.001). The cut off point to predict fibrosis

(1.7×10−3mm2/s) revealed 83% accuracy, 85% sensitivity, 82% specificity, 83%

PPV, and 85% NPV. The area under the curve was 0.91 for F1, 0.85 for F2, 0.86

for F3 and 0.90 for F4.

Conclusion

The apparent diffusion coefficient value is a promising quantitative parameter

used for diagnosis and quantification of hepatic fibrosis in children with

chronic hepatitis.

a Diagnostic Radiology Department, Mansoura Faculty of Medicine, 62 ElNokrasi

Street Meet Hadr, Mansoura 3512, Egypt

b Pediatric Department, Mansoura Faculty of Medicine, Mansoura, Egypt

c Diagnostic Pathology Department, Mansoura Faculty of Medicine, Mansoura, Egypt

[Guest guest]

http://www.ejradiology.com/article/PIIS0720048X09005762/abstract?rss=yes

EUROPEAN JOURNAL OF RADIOLOGY

Volume 78, Issue 1, Pages 129-134 (April 2011)

Diagnosis and quantification of hepatic fibrosis in children with diffusion

weighted MR imaging

Presented as oral presentation at RSNA2008

Ahmed Abdel Khalek Abdel Razeka, Ahmed Abdallab, Eman Omrana, Abeer Fathyb,

Khaled Zalatac

Received 25 July 2009; received in revised form 8 October 2009; accepted 9

October 2009.

Abstract

Purpose

To evaluate the accuracy of diffusion weighted MR imaging in diagnosis and

quantification of hepatic fibrosis in children with chronic hepatitis.

Materials and methods

Sixty-three consecutive children (40 boys, 23 girls, median age 9.3 years), with

chronic hepatitis and thirty age matched volunteers underwent diffusion weighted

MR imaging of the liver using a single shot echoplanar imaging with b-value=0,

250, and 500s/mm2. Liver biopsy was obtained with calculation of METAVIR score.

The ADC value of the liver was correlated with METAVIR score. Receiver operating

characteristic curve was done for diagnosis and grading of hepatic fibrosis.

Results

There was statistical difference in the mean ADC value between volunteers and

patients with hepatic fibrosis (P=0.001) and in patients with different grades

of METAVIR scores (P=0.002). There was correlation between the mean ADC value

and METAVIR score (r=0.807, P=0.001). The cut off point to predict fibrosis

(1.7×10−3mm2/s) revealed 83% accuracy, 85% sensitivity, 82% specificity, 83%

PPV, and 85% NPV. The area under the curve was 0.91 for F1, 0.85 for F2, 0.86

for F3 and 0.90 for F4.

Conclusion

The apparent diffusion coefficient value is a promising quantitative parameter

used for diagnosis and quantification of hepatic fibrosis in children with

chronic hepatitis.

a Diagnostic Radiology Department, Mansoura Faculty of Medicine, 62 ElNokrasi

Street Meet Hadr, Mansoura 3512, Egypt

b Pediatric Department, Mansoura Faculty of Medicine, Mansoura, Egypt

c Diagnostic Pathology Department, Mansoura Faculty of Medicine, Mansoura, Egypt

[Guest guest]

http://www.ejradiology.com/article/PIIS0720048X09005762/abstract?rss=yes

EUROPEAN JOURNAL OF RADIOLOGY

Volume 78, Issue 1, Pages 129-134 (April 2011)

Diagnosis and quantification of hepatic fibrosis in children with diffusion

weighted MR imaging

Presented as oral presentation at RSNA2008

Ahmed Abdel Khalek Abdel Razeka, Ahmed Abdallab, Eman Omrana, Abeer Fathyb,

Khaled Zalatac

Received 25 July 2009; received in revised form 8 October 2009; accepted 9

October 2009.

Abstract

Purpose

To evaluate the accuracy of diffusion weighted MR imaging in diagnosis and

quantification of hepatic fibrosis in children with chronic hepatitis.

Materials and methods

Sixty-three consecutive children (40 boys, 23 girls, median age 9.3 years), with

chronic hepatitis and thirty age matched volunteers underwent diffusion weighted

MR imaging of the liver using a single shot echoplanar imaging with b-value=0,

250, and 500s/mm2. Liver biopsy was obtained with calculation of METAVIR score.

The ADC value of the liver was correlated with METAVIR score. Receiver operating

characteristic curve was done for diagnosis and grading of hepatic fibrosis.

Results

There was statistical difference in the mean ADC value between volunteers and

patients with hepatic fibrosis (P=0.001) and in patients with different grades

of METAVIR scores (P=0.002). There was correlation between the mean ADC value

and METAVIR score (r=0.807, P=0.001). The cut off point to predict fibrosis

(1.7×10−3mm2/s) revealed 83% accuracy, 85% sensitivity, 82% specificity, 83%

PPV, and 85% NPV. The area under the curve was 0.91 for F1, 0.85 for F2, 0.86

for F3 and 0.90 for F4.

Conclusion

The apparent diffusion coefficient value is a promising quantitative parameter

used for diagnosis and quantification of hepatic fibrosis in children with

chronic hepatitis.

a Diagnostic Radiology Department, Mansoura Faculty of Medicine, 62 ElNokrasi

Street Meet Hadr, Mansoura 3512, Egypt

b Pediatric Department, Mansoura Faculty of Medicine, Mansoura, Egypt

c Diagnostic Pathology Department, Mansoura Faculty of Medicine, Mansoura, Egypt