FYI...Increased risk of parkinsonism among patients with cirrhosis: a 7-year follow-up study

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http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2010.02432.x/abstract

Increased risk of parkinsonism among patients with cirrhosis: a 7-year follow-up

study

Jiunn-Horng Kang1,2,†, Ming-Chieh Tsai3,4,†, Ching-Chun Lin5, Hsiu-Li Lin6,

Herng-Ching Lin5Article first published online: 11 JAN 2011

DOI: 10.1111/j.1478-3231.2010.02432.x

© 2011 Wiley & Sons A/S

Issue

Liver International

Early View (Articles online in advance of print)

Abstract

Background/Aims: Previous studies have suggested that hepatic (toxic-metabolic)

encephalopathy, the major complication of cirrhosis, is a neuropsychiatric

disorder typically seen in patients with liver dysfunction after exclusion of

other known brain disease. This study aims to investigate the risk for

parkinsonism during a 7-year follow-up period after a diagnosis of cirrhosis.

Methods: In total, 1361 patients with cirrhosis and 6805 comparison patients

without cirrhosis were included in this study. Each patient was then

individually tracked for 7 years from the time of their initial diagnosis of

cirrhosis to identify those who developed parkinsonism during the follow-up

period. Stratified proportional hazard regressions were conducted to

calculate the hazard of parkinsonism for the two groups during the follow-up

period, after adjusting for patient's age, monthly income, level of urbanization

and geographic location.

Results: Of the total 8166 sampled patients, 141 (1.7%) developed parkinsonism

during the follow-up period, 48 from the study group (3.5% of the patients with

cirrhosis) and 93 from the comparison group (1.4% of patients in the comparison

group). Stratified proportional hazard regressions show that the hazard for

parkinsonism for patients with cirrhosis was 2.65 times as high (95% confidence

interval=1.85–3.80, P<0.001) as the patients in the comparison group over the

7-year follow-up period, after adjusting for patient's age, monthly income,

level of urbanization and the geographic location of the community in which the

patient resided.

Conclusions: We concluded that cirrhosis significantly increased the risk of

parkinsonism.

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2010.02432.x/abstract

Increased risk of parkinsonism among patients with cirrhosis: a 7-year follow-up

study

Jiunn-Horng Kang1,2,†, Ming-Chieh Tsai3,4,†, Ching-Chun Lin5, Hsiu-Li Lin6,

Herng-Ching Lin5Article first published online: 11 JAN 2011

DOI: 10.1111/j.1478-3231.2010.02432.x

© 2011 Wiley & Sons A/S

Issue

Liver International

Early View (Articles online in advance of print)

Abstract

Background/Aims: Previous studies have suggested that hepatic (toxic-metabolic)

encephalopathy, the major complication of cirrhosis, is a neuropsychiatric

disorder typically seen in patients with liver dysfunction after exclusion of

other known brain disease. This study aims to investigate the risk for

parkinsonism during a 7-year follow-up period after a diagnosis of cirrhosis.

Methods: In total, 1361 patients with cirrhosis and 6805 comparison patients

without cirrhosis were included in this study. Each patient was then

individually tracked for 7 years from the time of their initial diagnosis of

cirrhosis to identify those who developed parkinsonism during the follow-up

period. Stratified proportional hazard regressions were conducted to

calculate the hazard of parkinsonism for the two groups during the follow-up

period, after adjusting for patient's age, monthly income, level of urbanization

and geographic location.

Results: Of the total 8166 sampled patients, 141 (1.7%) developed parkinsonism

during the follow-up period, 48 from the study group (3.5% of the patients with

cirrhosis) and 93 from the comparison group (1.4% of patients in the comparison

group). Stratified proportional hazard regressions show that the hazard for

parkinsonism for patients with cirrhosis was 2.65 times as high (95% confidence

interval=1.85–3.80, P<0.001) as the patients in the comparison group over the

7-year follow-up period, after adjusting for patient's age, monthly income,

level of urbanization and the geographic location of the community in which the

patient resided.

Conclusions: We concluded that cirrhosis significantly increased the risk of

parkinsonism.

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2010.02432.x/abstract

Increased risk of parkinsonism among patients with cirrhosis: a 7-year follow-up

study

Jiunn-Horng Kang1,2,†, Ming-Chieh Tsai3,4,†, Ching-Chun Lin5, Hsiu-Li Lin6,

Herng-Ching Lin5Article first published online: 11 JAN 2011

DOI: 10.1111/j.1478-3231.2010.02432.x

© 2011 Wiley & Sons A/S

Issue

Liver International

Early View (Articles online in advance of print)

Abstract

Background/Aims: Previous studies have suggested that hepatic (toxic-metabolic)

encephalopathy, the major complication of cirrhosis, is a neuropsychiatric

disorder typically seen in patients with liver dysfunction after exclusion of

other known brain disease. This study aims to investigate the risk for

parkinsonism during a 7-year follow-up period after a diagnosis of cirrhosis.

Methods: In total, 1361 patients with cirrhosis and 6805 comparison patients

without cirrhosis were included in this study. Each patient was then

individually tracked for 7 years from the time of their initial diagnosis of

cirrhosis to identify those who developed parkinsonism during the follow-up

period. Stratified proportional hazard regressions were conducted to

calculate the hazard of parkinsonism for the two groups during the follow-up

period, after adjusting for patient's age, monthly income, level of urbanization

and geographic location.

Results: Of the total 8166 sampled patients, 141 (1.7%) developed parkinsonism

during the follow-up period, 48 from the study group (3.5% of the patients with

cirrhosis) and 93 from the comparison group (1.4% of patients in the comparison

group). Stratified proportional hazard regressions show that the hazard for

parkinsonism for patients with cirrhosis was 2.65 times as high (95% confidence

interval=1.85–3.80, P<0.001) as the patients in the comparison group over the

7-year follow-up period, after adjusting for patient's age, monthly income,

level of urbanization and the geographic location of the community in which the

patient resided.

Conclusions: We concluded that cirrhosis significantly increased the risk of

parkinsonism.

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2010.02432.x/abstract

Increased risk of parkinsonism among patients with cirrhosis: a 7-year follow-up

study

Jiunn-Horng Kang1,2,†, Ming-Chieh Tsai3,4,†, Ching-Chun Lin5, Hsiu-Li Lin6,

Herng-Ching Lin5Article first published online: 11 JAN 2011

DOI: 10.1111/j.1478-3231.2010.02432.x

© 2011 Wiley & Sons A/S

Issue

Liver International

Early View (Articles online in advance of print)

Abstract

Background/Aims: Previous studies have suggested that hepatic (toxic-metabolic)

encephalopathy, the major complication of cirrhosis, is a neuropsychiatric

disorder typically seen in patients with liver dysfunction after exclusion of

other known brain disease. This study aims to investigate the risk for

parkinsonism during a 7-year follow-up period after a diagnosis of cirrhosis.

Methods: In total, 1361 patients with cirrhosis and 6805 comparison patients

without cirrhosis were included in this study. Each patient was then

individually tracked for 7 years from the time of their initial diagnosis of

cirrhosis to identify those who developed parkinsonism during the follow-up

period. Stratified proportional hazard regressions were conducted to

calculate the hazard of parkinsonism for the two groups during the follow-up

period, after adjusting for patient's age, monthly income, level of urbanization

and geographic location.

Results: Of the total 8166 sampled patients, 141 (1.7%) developed parkinsonism

during the follow-up period, 48 from the study group (3.5% of the patients with

cirrhosis) and 93 from the comparison group (1.4% of patients in the comparison

group). Stratified proportional hazard regressions show that the hazard for

parkinsonism for patients with cirrhosis was 2.65 times as high (95% confidence

interval=1.85–3.80, P<0.001) as the patients in the comparison group over the

7-year follow-up period, after adjusting for patient's age, monthly income,

level of urbanization and the geographic location of the community in which the

patient resided.

Conclusions: We concluded that cirrhosis significantly increased the risk of

parkinsonism.