A 40-Year-Old Female Patient with Seronegative Autoimmune Hepatitis following a Newly Acquired Hepat

[Guest guest]

Z Gastroenterol. 2008 Feb;46(2):201-5.

[A 40-Year-Old Female Patient with Seronegative Autoimmune Hepatitis following a

Newly Acquired Hepatitis B Infection.][Article in German]

Zizer E, Hasel C, Seufferlein T, Adler G, Dikopoulos N.

Klinik für Innere Medizin I, Zentrum für Innere Medizin, Universitätsklinikum

Ulm.

We report the case of a 40-year-old female patient admitted at our clinic

because of recent onset jaundice and elevated transaminases. Two months before

admission the patient had unprotected sexual contact with a potential hepatitis

B-infected man. Virological screening performed in our clinic revealed IgM

antibodies against hepatitis B virus core protein (anti-HBc-IgM) and elevated

HBV-DNA. Our first diagnosis was an acute hepatitis B virus infection. During

her stay at our clinic the patient achieved HBe seroconversion and a loss of

HBV-DNA. Nevertheless the transaminases remained high and jaundice persisted.

The histological examination of the liver biopsy showed interface hepatitis with

plasma cells as the characteristic signs of autoimmune hepatitis. On that basis

we started an immunosuppressive therapy with prednisolone in parallel with a

prophylactic lamivudine therapy and after two weeks there was a complete

resolution of jaundice and a normalisation of transaminases. In conclusion, we

present a rare case report of an autoimmune hepatitis as a result a newly

acquired hepatitis B infection. This case report highlights the relationship

between viral infection and autoimmunity within the liver.

PMID: 18253899 [PubMed - in process]

_________________________________________________________________

Climb to the top of the charts! Play the word scramble challenge with star

power.

http://club.live.com/star_shuffle.aspx?icid=starshuffle_wlmailtextlink_jan

[Guest guest]

Z Gastroenterol. 2008 Feb;46(2):201-5.

[A 40-Year-Old Female Patient with Seronegative Autoimmune Hepatitis following a

Newly Acquired Hepatitis B Infection.][Article in German]

Zizer E, Hasel C, Seufferlein T, Adler G, Dikopoulos N.

Klinik für Innere Medizin I, Zentrum für Innere Medizin, Universitätsklinikum

Ulm.

We report the case of a 40-year-old female patient admitted at our clinic

because of recent onset jaundice and elevated transaminases. Two months before

admission the patient had unprotected sexual contact with a potential hepatitis

B-infected man. Virological screening performed in our clinic revealed IgM

antibodies against hepatitis B virus core protein (anti-HBc-IgM) and elevated

HBV-DNA. Our first diagnosis was an acute hepatitis B virus infection. During

her stay at our clinic the patient achieved HBe seroconversion and a loss of

HBV-DNA. Nevertheless the transaminases remained high and jaundice persisted.

The histological examination of the liver biopsy showed interface hepatitis with

plasma cells as the characteristic signs of autoimmune hepatitis. On that basis

we started an immunosuppressive therapy with prednisolone in parallel with a

prophylactic lamivudine therapy and after two weeks there was a complete

resolution of jaundice and a normalisation of transaminases. In conclusion, we

present a rare case report of an autoimmune hepatitis as a result a newly

acquired hepatitis B infection. This case report highlights the relationship

between viral infection and autoimmunity within the liver.

PMID: 18253899 [PubMed - in process]

_________________________________________________________________

Climb to the top of the charts! Play the word scramble challenge with star

power.

http://club.live.com/star_shuffle.aspx?icid=starshuffle_wlmailtextlink_jan

[Guest guest]

Z Gastroenterol. 2008 Feb;46(2):201-5.

[A 40-Year-Old Female Patient with Seronegative Autoimmune Hepatitis following a

Newly Acquired Hepatitis B Infection.][Article in German]

Zizer E, Hasel C, Seufferlein T, Adler G, Dikopoulos N.

Klinik für Innere Medizin I, Zentrum für Innere Medizin, Universitätsklinikum

Ulm.

We report the case of a 40-year-old female patient admitted at our clinic

because of recent onset jaundice and elevated transaminases. Two months before

admission the patient had unprotected sexual contact with a potential hepatitis

B-infected man. Virological screening performed in our clinic revealed IgM

antibodies against hepatitis B virus core protein (anti-HBc-IgM) and elevated

HBV-DNA. Our first diagnosis was an acute hepatitis B virus infection. During

her stay at our clinic the patient achieved HBe seroconversion and a loss of

HBV-DNA. Nevertheless the transaminases remained high and jaundice persisted.

The histological examination of the liver biopsy showed interface hepatitis with

plasma cells as the characteristic signs of autoimmune hepatitis. On that basis

we started an immunosuppressive therapy with prednisolone in parallel with a

prophylactic lamivudine therapy and after two weeks there was a complete

resolution of jaundice and a normalisation of transaminases. In conclusion, we

present a rare case report of an autoimmune hepatitis as a result a newly

acquired hepatitis B infection. This case report highlights the relationship

between viral infection and autoimmunity within the liver.

PMID: 18253899 [PubMed - in process]

_________________________________________________________________

Climb to the top of the charts! Play the word scramble challenge with star

power.

http://club.live.com/star_shuffle.aspx?icid=starshuffle_wlmailtextlink_jan

[Guest guest]

Z Gastroenterol. 2008 Feb;46(2):201-5.

[A 40-Year-Old Female Patient with Seronegative Autoimmune Hepatitis following a

Newly Acquired Hepatitis B Infection.][Article in German]

Zizer E, Hasel C, Seufferlein T, Adler G, Dikopoulos N.

Klinik für Innere Medizin I, Zentrum für Innere Medizin, Universitätsklinikum

Ulm.

We report the case of a 40-year-old female patient admitted at our clinic

because of recent onset jaundice and elevated transaminases. Two months before

admission the patient had unprotected sexual contact with a potential hepatitis

B-infected man. Virological screening performed in our clinic revealed IgM

antibodies against hepatitis B virus core protein (anti-HBc-IgM) and elevated

HBV-DNA. Our first diagnosis was an acute hepatitis B virus infection. During

her stay at our clinic the patient achieved HBe seroconversion and a loss of

HBV-DNA. Nevertheless the transaminases remained high and jaundice persisted.

The histological examination of the liver biopsy showed interface hepatitis with

plasma cells as the characteristic signs of autoimmune hepatitis. On that basis

we started an immunosuppressive therapy with prednisolone in parallel with a

prophylactic lamivudine therapy and after two weeks there was a complete

resolution of jaundice and a normalisation of transaminases. In conclusion, we

present a rare case report of an autoimmune hepatitis as a result a newly

acquired hepatitis B infection. This case report highlights the relationship

between viral infection and autoimmunity within the liver.

PMID: 18253899 [PubMed - in process]

_________________________________________________________________

Climb to the top of the charts! Play the word scramble challenge with star

power.

http://club.live.com/star_shuffle.aspx?icid=starshuffle_wlmailtextlink_jan