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Viral factors and outcomes of chronic HBV infection

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Am J Gastroenterol. 2011 Jan;106(1):93-5.

Viral factors and outcomes of chronic HBV infection.

Huang Y, Lok AS.

Comment on:

Am J Gastroenterol. 2011 Jan;106(1):81-92.

Abstract

Viral factors associated with outcome of chronic hepatitis B virus (HBV)

infection include hepatitis B e antigen status, HBV DNA, genotype, and HBV

variants. Mutations in the HBV core promoter region have been shown to be

independently associated with hepatocellular carcinoma (HCC). The most common

core promoter mutations involve a double substitution A1762T and G1764A (TA).

Besides TA mutations, several other core promoter changes have been reported to

be associated with the development of cirrhosis and HCC. Future studies should

determine if detection of these changes can predict the outcome of patients with

chronic HBV infection.

PMID: 21212756 [PubMed - indexed for MEDLINE]

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Posted
Posted

Am J Gastroenterol. 2011 Jan;106(1):93-5.

Viral factors and outcomes of chronic HBV infection.

Huang Y, Lok AS.

Comment on:

Am J Gastroenterol. 2011 Jan;106(1):81-92.

Abstract

Viral factors associated with outcome of chronic hepatitis B virus (HBV)

infection include hepatitis B e antigen status, HBV DNA, genotype, and HBV

variants. Mutations in the HBV core promoter region have been shown to be

independently associated with hepatocellular carcinoma (HCC). The most common

core promoter mutations involve a double substitution A1762T and G1764A (TA).

Besides TA mutations, several other core promoter changes have been reported to

be associated with the development of cirrhosis and HCC. Future studies should

determine if detection of these changes can predict the outcome of patients with

chronic HBV infection.

PMID: 21212756 [PubMed - indexed for MEDLINE]

Link to comment
Share on other sites
Guest guest

Guest guest

Posted
Posted

Am J Gastroenterol. 2011 Jan;106(1):93-5.

Viral factors and outcomes of chronic HBV infection.

Huang Y, Lok AS.

Comment on:

Am J Gastroenterol. 2011 Jan;106(1):81-92.

Abstract

Viral factors associated with outcome of chronic hepatitis B virus (HBV)

infection include hepatitis B e antigen status, HBV DNA, genotype, and HBV

variants. Mutations in the HBV core promoter region have been shown to be

independently associated with hepatocellular carcinoma (HCC). The most common

core promoter mutations involve a double substitution A1762T and G1764A (TA).

Besides TA mutations, several other core promoter changes have been reported to

be associated with the development of cirrhosis and HCC. Future studies should

determine if detection of these changes can predict the outcome of patients with

chronic HBV infection.

PMID: 21212756 [PubMed - indexed for MEDLINE]

Link to comment
Share on other sites
Guest guest

Guest guest

Posted
Posted

Am J Gastroenterol. 2011 Jan;106(1):93-5.

Viral factors and outcomes of chronic HBV infection.

Huang Y, Lok AS.

Comment on:

Am J Gastroenterol. 2011 Jan;106(1):81-92.

Abstract

Viral factors associated with outcome of chronic hepatitis B virus (HBV)

infection include hepatitis B e antigen status, HBV DNA, genotype, and HBV

variants. Mutations in the HBV core promoter region have been shown to be

independently associated with hepatocellular carcinoma (HCC). The most common

core promoter mutations involve a double substitution A1762T and G1764A (TA).

Besides TA mutations, several other core promoter changes have been reported to

be associated with the development of cirrhosis and HCC. Future studies should

determine if detection of these changes can predict the outcome of patients with

chronic HBV infection.

PMID: 21212756 [PubMed - indexed for MEDLINE]

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