Virologic monitoring of hepatitis B virus therapy in clinical trials and practice: recommendations f

[Guest guest]

Gastroenterology. 2008 Feb;134(2):405-15. Epub 2007 Nov 28.

Virologic monitoring of hepatitis B virus therapy in clinical trials and

practice: recommendations for a standardized approach.

Pawlotsky JM, Dusheiko G, Hatzakis A, Lau D, Lau G, Liang TJ, Locarnini S,

P, Richman DD, Zoulim F.

French National Reference Center for Viral Hepatitis B, C and delta, Department

of Virology, Henri Mondor Hospital, University of Paris XII, Créteil, France.

jean-michel.pawlotsky@...

Treatment of chronic hepatitis B virus (HBV) infection is aimed at suppressing

viral replication to the lowest possible level, and thereby to halt the

progression of liver disease and prevent the onset of complications. Two

categories of drugs are used in HBV therapy: the interferons, including standard

interferon alfa or pegylated interferon alfa, and specific nucleoside or

nucleotide HBV inhibitors that target the reverse-transcriptase function of

HBV-DNA polymerase. The reported results of clinical trials have used varying

definitions of efficacy, failure, and resistance based on different measures of

virologic responses. This article discusses HBV virologic markers and tests, and

their optimal use both for planning and reporting clinical trials and in

clinical practice.

PMID: 18242209 [PubMed - indexed for MEDLINE]

_________________________________________________________________

Need to know the score, the latest news, or you need your Hotmail®-get your

" fix " .

http://www.msnmobilefix.com/Default.aspx

[Guest guest]

Gastroenterology. 2008 Feb;134(2):405-15. Epub 2007 Nov 28.

Virologic monitoring of hepatitis B virus therapy in clinical trials and

practice: recommendations for a standardized approach.

Pawlotsky JM, Dusheiko G, Hatzakis A, Lau D, Lau G, Liang TJ, Locarnini S,

P, Richman DD, Zoulim F.

French National Reference Center for Viral Hepatitis B, C and delta, Department

of Virology, Henri Mondor Hospital, University of Paris XII, Créteil, France.

jean-michel.pawlotsky@...

Treatment of chronic hepatitis B virus (HBV) infection is aimed at suppressing

viral replication to the lowest possible level, and thereby to halt the

progression of liver disease and prevent the onset of complications. Two

categories of drugs are used in HBV therapy: the interferons, including standard

interferon alfa or pegylated interferon alfa, and specific nucleoside or

nucleotide HBV inhibitors that target the reverse-transcriptase function of

HBV-DNA polymerase. The reported results of clinical trials have used varying

definitions of efficacy, failure, and resistance based on different measures of

virologic responses. This article discusses HBV virologic markers and tests, and

their optimal use both for planning and reporting clinical trials and in

clinical practice.

PMID: 18242209 [PubMed - indexed for MEDLINE]

_________________________________________________________________

Need to know the score, the latest news, or you need your Hotmail®-get your

" fix " .

http://www.msnmobilefix.com/Default.aspx

[Guest guest]

Gastroenterology. 2008 Feb;134(2):405-15. Epub 2007 Nov 28.

Virologic monitoring of hepatitis B virus therapy in clinical trials and

practice: recommendations for a standardized approach.

Pawlotsky JM, Dusheiko G, Hatzakis A, Lau D, Lau G, Liang TJ, Locarnini S,

P, Richman DD, Zoulim F.

French National Reference Center for Viral Hepatitis B, C and delta, Department

of Virology, Henri Mondor Hospital, University of Paris XII, Créteil, France.

jean-michel.pawlotsky@...

Treatment of chronic hepatitis B virus (HBV) infection is aimed at suppressing

viral replication to the lowest possible level, and thereby to halt the

progression of liver disease and prevent the onset of complications. Two

categories of drugs are used in HBV therapy: the interferons, including standard

interferon alfa or pegylated interferon alfa, and specific nucleoside or

nucleotide HBV inhibitors that target the reverse-transcriptase function of

HBV-DNA polymerase. The reported results of clinical trials have used varying

definitions of efficacy, failure, and resistance based on different measures of

virologic responses. This article discusses HBV virologic markers and tests, and

their optimal use both for planning and reporting clinical trials and in

clinical practice.

PMID: 18242209 [PubMed - indexed for MEDLINE]

_________________________________________________________________

Need to know the score, the latest news, or you need your Hotmail®-get your

" fix " .

http://www.msnmobilefix.com/Default.aspx

[Guest guest]

Gastroenterology. 2008 Feb;134(2):405-15. Epub 2007 Nov 28.

Virologic monitoring of hepatitis B virus therapy in clinical trials and

practice: recommendations for a standardized approach.

Pawlotsky JM, Dusheiko G, Hatzakis A, Lau D, Lau G, Liang TJ, Locarnini S,

P, Richman DD, Zoulim F.

French National Reference Center for Viral Hepatitis B, C and delta, Department

of Virology, Henri Mondor Hospital, University of Paris XII, Créteil, France.

jean-michel.pawlotsky@...

Treatment of chronic hepatitis B virus (HBV) infection is aimed at suppressing

viral replication to the lowest possible level, and thereby to halt the

progression of liver disease and prevent the onset of complications. Two

categories of drugs are used in HBV therapy: the interferons, including standard

interferon alfa or pegylated interferon alfa, and specific nucleoside or

nucleotide HBV inhibitors that target the reverse-transcriptase function of

HBV-DNA polymerase. The reported results of clinical trials have used varying

definitions of efficacy, failure, and resistance based on different measures of

virologic responses. This article discusses HBV virologic markers and tests, and

their optimal use both for planning and reporting clinical trials and in

clinical practice.

PMID: 18242209 [PubMed - indexed for MEDLINE]

_________________________________________________________________

Need to know the score, the latest news, or you need your Hotmail®-get your

" fix " .

http://www.msnmobilefix.com/Default.aspx