A Comparison of Prognosis between Patients with Hepatitis B and C Virus-related Hepatocellular Carcinoma Undergoing Resection Surgery

[Guest guest]

http://www.springerlink.com/content/x3v28306040p7272/

World Journal of Surgery

DOI: 10.1007/s00268-010-0928-zOnline First™

A Comparison of Prognosis between Patients with Hepatitis B and C Virus-related

Hepatocellular Carcinoma Undergoing Resection Surgery

Wei-Yu Kao, Chien-Wei Su, Gar-Yang Chau, Wing-Yiu Lui, Chew-Wun Wu and Jaw-Ching

Wu

Abstract

Background

The impact of viral factors on the prognosis of hepatocellular carcinoma (HCC)

remains controversial because of heterogeneous populations included in previous

reports. This study aims to compare clinicopathologic features and prognoses

between patients with hepatitis B- and hepatitis C-related HCC who underwent

resection surgery.

Methods

We enrolled 609 patients with positive serum hepatitis B virus (HBV) surface

antigen (HBsAg) and negative serum antibody against hepatitis C virus (anti-HCV)

as the B-HCC group and 206 patients with negative serum HBsAg and positive

anti-HCV as the C-HCC group. The overall survival rates and cumulative

recurrence rates were compared between these two groups.

Results

B-HCC patients were significantly younger, predominantly male, had better liver

functional reserve, but more advanced tumor stage than C-HCC patients. After a

median follow-up period of 40.6 months, 427 patients had died. Furthermore, 501

patients had tumor recurrence after surgery. The postoperative overall survival

rates (p = 0.640) and recurrence rates (p = 0.387) of the two groups were

comparable. However, the overall survival rate was higher in the B-HCC group

than in the C-HCC group in the cases of transplantable HCC (p = 0.021) and

Barcelona-Clinic Liver Cancer stage A HCC (p = 0.040).

Conclusions

Viral etiologies were not apparent in determining outcomes of HCC patients who

underwent resection due to heterogeneous studied populations. In early-stage

HCC, B-HCC patients had better outcomes than C-HCC patients did because of

better liver reserve and less hepatic inflammation.

[Guest guest]

http://www.springerlink.com/content/x3v28306040p7272/

World Journal of Surgery

DOI: 10.1007/s00268-010-0928-zOnline First™

A Comparison of Prognosis between Patients with Hepatitis B and C Virus-related

Hepatocellular Carcinoma Undergoing Resection Surgery

Wei-Yu Kao, Chien-Wei Su, Gar-Yang Chau, Wing-Yiu Lui, Chew-Wun Wu and Jaw-Ching

Wu

Abstract

Background

The impact of viral factors on the prognosis of hepatocellular carcinoma (HCC)

remains controversial because of heterogeneous populations included in previous

reports. This study aims to compare clinicopathologic features and prognoses

between patients with hepatitis B- and hepatitis C-related HCC who underwent

resection surgery.

Methods

We enrolled 609 patients with positive serum hepatitis B virus (HBV) surface

antigen (HBsAg) and negative serum antibody against hepatitis C virus (anti-HCV)

as the B-HCC group and 206 patients with negative serum HBsAg and positive

anti-HCV as the C-HCC group. The overall survival rates and cumulative

recurrence rates were compared between these two groups.

Results

B-HCC patients were significantly younger, predominantly male, had better liver

functional reserve, but more advanced tumor stage than C-HCC patients. After a

median follow-up period of 40.6 months, 427 patients had died. Furthermore, 501

patients had tumor recurrence after surgery. The postoperative overall survival

rates (p = 0.640) and recurrence rates (p = 0.387) of the two groups were

comparable. However, the overall survival rate was higher in the B-HCC group

than in the C-HCC group in the cases of transplantable HCC (p = 0.021) and

Barcelona-Clinic Liver Cancer stage A HCC (p = 0.040).

Conclusions

Viral etiologies were not apparent in determining outcomes of HCC patients who

underwent resection due to heterogeneous studied populations. In early-stage

HCC, B-HCC patients had better outcomes than C-HCC patients did because of

better liver reserve and less hepatic inflammation.

[Guest guest]

http://www.springerlink.com/content/x3v28306040p7272/

World Journal of Surgery

DOI: 10.1007/s00268-010-0928-zOnline First™

A Comparison of Prognosis between Patients with Hepatitis B and C Virus-related

Hepatocellular Carcinoma Undergoing Resection Surgery

Wei-Yu Kao, Chien-Wei Su, Gar-Yang Chau, Wing-Yiu Lui, Chew-Wun Wu and Jaw-Ching

Wu

Abstract

Background

The impact of viral factors on the prognosis of hepatocellular carcinoma (HCC)

remains controversial because of heterogeneous populations included in previous

reports. This study aims to compare clinicopathologic features and prognoses

between patients with hepatitis B- and hepatitis C-related HCC who underwent

resection surgery.

Methods

We enrolled 609 patients with positive serum hepatitis B virus (HBV) surface

antigen (HBsAg) and negative serum antibody against hepatitis C virus (anti-HCV)

as the B-HCC group and 206 patients with negative serum HBsAg and positive

anti-HCV as the C-HCC group. The overall survival rates and cumulative

recurrence rates were compared between these two groups.

Results

B-HCC patients were significantly younger, predominantly male, had better liver

functional reserve, but more advanced tumor stage than C-HCC patients. After a

median follow-up period of 40.6 months, 427 patients had died. Furthermore, 501

patients had tumor recurrence after surgery. The postoperative overall survival

rates (p = 0.640) and recurrence rates (p = 0.387) of the two groups were

comparable. However, the overall survival rate was higher in the B-HCC group

than in the C-HCC group in the cases of transplantable HCC (p = 0.021) and

Barcelona-Clinic Liver Cancer stage A HCC (p = 0.040).

Conclusions

Viral etiologies were not apparent in determining outcomes of HCC patients who

underwent resection due to heterogeneous studied populations. In early-stage

HCC, B-HCC patients had better outcomes than C-HCC patients did because of

better liver reserve and less hepatic inflammation.

[Guest guest]

http://www.springerlink.com/content/x3v28306040p7272/

World Journal of Surgery

DOI: 10.1007/s00268-010-0928-zOnline First™

A Comparison of Prognosis between Patients with Hepatitis B and C Virus-related

Hepatocellular Carcinoma Undergoing Resection Surgery

Wei-Yu Kao, Chien-Wei Su, Gar-Yang Chau, Wing-Yiu Lui, Chew-Wun Wu and Jaw-Ching

Wu

Abstract

Background

The impact of viral factors on the prognosis of hepatocellular carcinoma (HCC)

remains controversial because of heterogeneous populations included in previous

reports. This study aims to compare clinicopathologic features and prognoses

between patients with hepatitis B- and hepatitis C-related HCC who underwent

resection surgery.

Methods

We enrolled 609 patients with positive serum hepatitis B virus (HBV) surface

antigen (HBsAg) and negative serum antibody against hepatitis C virus (anti-HCV)

as the B-HCC group and 206 patients with negative serum HBsAg and positive

anti-HCV as the C-HCC group. The overall survival rates and cumulative

recurrence rates were compared between these two groups.

Results

B-HCC patients were significantly younger, predominantly male, had better liver

functional reserve, but more advanced tumor stage than C-HCC patients. After a

median follow-up period of 40.6 months, 427 patients had died. Furthermore, 501

patients had tumor recurrence after surgery. The postoperative overall survival

rates (p = 0.640) and recurrence rates (p = 0.387) of the two groups were

comparable. However, the overall survival rate was higher in the B-HCC group

than in the C-HCC group in the cases of transplantable HCC (p = 0.021) and

Barcelona-Clinic Liver Cancer stage A HCC (p = 0.040).

Conclusions

Viral etiologies were not apparent in determining outcomes of HCC patients who

underwent resection due to heterogeneous studied populations. In early-stage

HCC, B-HCC patients had better outcomes than C-HCC patients did because of

better liver reserve and less hepatic inflammation.