The impact of mode of acquisition on biological markers of paediatric hepatitis C virus infection

[Guest guest]

http://www.ingentaconnect.com/content/bsc/jvh/2011/00000018/00000008/art00002

Journal of Viral Hepatitis, Volume 18, Number 8

The impact of mode of acquisition on biological markers of paediatric hepatitis

C virus infection

Authors: England, K.1; Thorne, C.1; , H.2; Ramsay, M.2; Newell, M.-L.

Source: Journal of Viral Hepatitis, Volume 18, Number 8, 1 August 2011 , pp.

533-541(9)

Publisher: Wiley-Blackwell

Abstract:

Summary.  Despite the introduction of blood donor screening, worldwide,

children continue to become infected with hepatitis C virus (HCV) via un-sterile

medical injections, receipt of unscreened blood and isolated hospital

contamination outbreaks. It is plausible that the natural history and disease

progression in these children might differ from that of their vertically

infected counterparts. Vertically and parenterally HCV-infected children were

prospectively followed within the European Paediatric HCV Network and the UK

National HCV Register, respectively. Biological profiles were compared.

Vertically and parenterally HCV-infected children differed in terms of some key

characteristics including the male to female ratio and the proportion of

children receiving therapy. Parenterally infected children were more likely to

have at least one hepatomegaly event during follow-up, 20%vs 10%. Parenteral

infection did not significantly affect the odds of being consistently viraemic

(AOR 1.14, P = 0.703) and there was no significant difference in the odds of

having consistently elevated ALT levels and mode of acquisition (AOR 0.83,

P = 0.748). The proportion of children with 2 or more markers of HCV

infection did not differ significantly by mode of acquisition (χ2 1.13,

P = 0.288). This analysis does not support substantial differences between

vertically and parenterally infected groups, but there are specific mechanisms

identified requiring further investigation. Given the continued parenteral

infection of children worldwide, it is vital that knowledge of disease

progression in this group is accurate and that the differences in comparison

with vertically infected children are clarified to inform more accurate and

individualized clinical management.

Document Type: Research article

DOI: 10.1111/j.1365-2893.2011.01128.x

Affiliations:1: MRC Centre of Epidemiology for Child Health, UCL Institute of

Child Health, London, UK 2: Immunisation Department, Centre for Infections,

Health Protection Agency, London, UK

Publication date: 2011-08-01

[Guest guest]

http://www.ingentaconnect.com/content/bsc/jvh/2011/00000018/00000008/art00002

Journal of Viral Hepatitis, Volume 18, Number 8

The impact of mode of acquisition on biological markers of paediatric hepatitis

C virus infection

Authors: England, K.1; Thorne, C.1; , H.2; Ramsay, M.2; Newell, M.-L.

Source: Journal of Viral Hepatitis, Volume 18, Number 8, 1 August 2011 , pp.

533-541(9)

Publisher: Wiley-Blackwell

Abstract:

Summary.  Despite the introduction of blood donor screening, worldwide,

children continue to become infected with hepatitis C virus (HCV) via un-sterile

medical injections, receipt of unscreened blood and isolated hospital

contamination outbreaks. It is plausible that the natural history and disease

progression in these children might differ from that of their vertically

infected counterparts. Vertically and parenterally HCV-infected children were

prospectively followed within the European Paediatric HCV Network and the UK

National HCV Register, respectively. Biological profiles were compared.

Vertically and parenterally HCV-infected children differed in terms of some key

characteristics including the male to female ratio and the proportion of

children receiving therapy. Parenterally infected children were more likely to

have at least one hepatomegaly event during follow-up, 20%vs 10%. Parenteral

infection did not significantly affect the odds of being consistently viraemic

(AOR 1.14, P = 0.703) and there was no significant difference in the odds of

having consistently elevated ALT levels and mode of acquisition (AOR 0.83,

P = 0.748). The proportion of children with 2 or more markers of HCV

infection did not differ significantly by mode of acquisition (χ2 1.13,

P = 0.288). This analysis does not support substantial differences between

vertically and parenterally infected groups, but there are specific mechanisms

identified requiring further investigation. Given the continued parenteral

infection of children worldwide, it is vital that knowledge of disease

progression in this group is accurate and that the differences in comparison

with vertically infected children are clarified to inform more accurate and

individualized clinical management.

Document Type: Research article

DOI: 10.1111/j.1365-2893.2011.01128.x

Affiliations:1: MRC Centre of Epidemiology for Child Health, UCL Institute of

Child Health, London, UK 2: Immunisation Department, Centre for Infections,

Health Protection Agency, London, UK

Publication date: 2011-08-01

[Guest guest]

http://www.ingentaconnect.com/content/bsc/jvh/2011/00000018/00000008/art00002

Journal of Viral Hepatitis, Volume 18, Number 8

The impact of mode of acquisition on biological markers of paediatric hepatitis

C virus infection

Authors: England, K.1; Thorne, C.1; , H.2; Ramsay, M.2; Newell, M.-L.

Source: Journal of Viral Hepatitis, Volume 18, Number 8, 1 August 2011 , pp.

533-541(9)

Publisher: Wiley-Blackwell

Abstract:

Summary.  Despite the introduction of blood donor screening, worldwide,

children continue to become infected with hepatitis C virus (HCV) via un-sterile

medical injections, receipt of unscreened blood and isolated hospital

contamination outbreaks. It is plausible that the natural history and disease

progression in these children might differ from that of their vertically

infected counterparts. Vertically and parenterally HCV-infected children were

prospectively followed within the European Paediatric HCV Network and the UK

National HCV Register, respectively. Biological profiles were compared.

Vertically and parenterally HCV-infected children differed in terms of some key

characteristics including the male to female ratio and the proportion of

children receiving therapy. Parenterally infected children were more likely to

have at least one hepatomegaly event during follow-up, 20%vs 10%. Parenteral

infection did not significantly affect the odds of being consistently viraemic

(AOR 1.14, P = 0.703) and there was no significant difference in the odds of

having consistently elevated ALT levels and mode of acquisition (AOR 0.83,

P = 0.748). The proportion of children with 2 or more markers of HCV

infection did not differ significantly by mode of acquisition (χ2 1.13,

P = 0.288). This analysis does not support substantial differences between

vertically and parenterally infected groups, but there are specific mechanisms

identified requiring further investigation. Given the continued parenteral

infection of children worldwide, it is vital that knowledge of disease

progression in this group is accurate and that the differences in comparison

with vertically infected children are clarified to inform more accurate and

individualized clinical management.

Document Type: Research article

DOI: 10.1111/j.1365-2893.2011.01128.x

Affiliations:1: MRC Centre of Epidemiology for Child Health, UCL Institute of

Child Health, London, UK 2: Immunisation Department, Centre for Infections,

Health Protection Agency, London, UK

Publication date: 2011-08-01

[Guest guest]

http://www.ingentaconnect.com/content/bsc/jvh/2011/00000018/00000008/art00002

Journal of Viral Hepatitis, Volume 18, Number 8

The impact of mode of acquisition on biological markers of paediatric hepatitis

C virus infection

Authors: England, K.1; Thorne, C.1; , H.2; Ramsay, M.2; Newell, M.-L.

Source: Journal of Viral Hepatitis, Volume 18, Number 8, 1 August 2011 , pp.

533-541(9)

Publisher: Wiley-Blackwell

Abstract:

Summary.  Despite the introduction of blood donor screening, worldwide,

children continue to become infected with hepatitis C virus (HCV) via un-sterile

medical injections, receipt of unscreened blood and isolated hospital

contamination outbreaks. It is plausible that the natural history and disease

progression in these children might differ from that of their vertically

infected counterparts. Vertically and parenterally HCV-infected children were

prospectively followed within the European Paediatric HCV Network and the UK

National HCV Register, respectively. Biological profiles were compared.

Vertically and parenterally HCV-infected children differed in terms of some key

characteristics including the male to female ratio and the proportion of

children receiving therapy. Parenterally infected children were more likely to

have at least one hepatomegaly event during follow-up, 20%vs 10%. Parenteral

infection did not significantly affect the odds of being consistently viraemic

(AOR 1.14, P = 0.703) and there was no significant difference in the odds of

having consistently elevated ALT levels and mode of acquisition (AOR 0.83,

P = 0.748). The proportion of children with 2 or more markers of HCV

infection did not differ significantly by mode of acquisition (χ2 1.13,

P = 0.288). This analysis does not support substantial differences between

vertically and parenterally infected groups, but there are specific mechanisms

identified requiring further investigation. Given the continued parenteral

infection of children worldwide, it is vital that knowledge of disease

progression in this group is accurate and that the differences in comparison

with vertically infected children are clarified to inform more accurate and

individualized clinical management.

Document Type: Research article

DOI: 10.1111/j.1365-2893.2011.01128.x

Affiliations:1: MRC Centre of Epidemiology for Child Health, UCL Institute of

Child Health, London, UK 2: Immunisation Department, Centre for Infections,

Health Protection Agency, London, UK

Publication date: 2011-08-01