FYI.....Autochthonous Hepatitis E - Virus Infection as Cause of Acute Hepatitis in Germany - a Case Report

[Guest guest]

Z Gastroenterol. 2011 Jan;49(1):42-46. Epub 2011 Jan 10.

[Autochthonous Hepatitis E-Virus Infection as Cause of Acute Hepatitis in

Germany - a Case Report.]

[Article in German]

Veitt R, Reichardt M, Wenzel J, Jilg W.

Klinik für Innere Medizin I, Kreiskrankenhaus Schmalkalden.

Abstract

There is an increasing body of evidence that hepatitis E virus (HEV) triggers

acute hepatitis not only in tropical and subtropical regions of Asia, Africa,

and America with low sanitary standards but also in highly industrialized

countries. We here report on two patients from Thuringia (Germany) with a HEV

infection without a recent stay abroad. All other common causes of hepatitis

were excluded. Transaminases were significantly incresed in both cases, while

icterus could be proven in one patient, only. Both patients fully recovered in

the long-term course. Epidemiological and phylogenetic data from viral analyses

suggest that HEV infection has to be considered as a zoonosis. It is likely that

viral transmission from animals to humans occurs through insufficiently cooked

meat or entrails, e. g., from pigs or wild animals. In summary, HEV infection is

a relevant differential diagnosis in acute non-A/B/C viral hepatitis. Further

studies are required for the identification of other transmission pathways,

pathogen reservoirs as well as novel concepts for prophylaxis, especially for

patients at risk for hepatic diseases.© Georg Thieme Verlag KG Stuttgart · New

York.

PMID: 21225537 [PubMed - as supplied by publisher]

[Guest guest]

Z Gastroenterol. 2011 Jan;49(1):42-46. Epub 2011 Jan 10.

[Autochthonous Hepatitis E-Virus Infection as Cause of Acute Hepatitis in

Germany - a Case Report.]

[Article in German]

Veitt R, Reichardt M, Wenzel J, Jilg W.

Klinik für Innere Medizin I, Kreiskrankenhaus Schmalkalden.

Abstract

There is an increasing body of evidence that hepatitis E virus (HEV) triggers

acute hepatitis not only in tropical and subtropical regions of Asia, Africa,

and America with low sanitary standards but also in highly industrialized

countries. We here report on two patients from Thuringia (Germany) with a HEV

infection without a recent stay abroad. All other common causes of hepatitis

were excluded. Transaminases were significantly incresed in both cases, while

icterus could be proven in one patient, only. Both patients fully recovered in

the long-term course. Epidemiological and phylogenetic data from viral analyses

suggest that HEV infection has to be considered as a zoonosis. It is likely that

viral transmission from animals to humans occurs through insufficiently cooked

meat or entrails, e. g., from pigs or wild animals. In summary, HEV infection is

a relevant differential diagnosis in acute non-A/B/C viral hepatitis. Further

studies are required for the identification of other transmission pathways,

pathogen reservoirs as well as novel concepts for prophylaxis, especially for

patients at risk for hepatic diseases.© Georg Thieme Verlag KG Stuttgart · New

York.

PMID: 21225537 [PubMed - as supplied by publisher]

[Guest guest]

Z Gastroenterol. 2011 Jan;49(1):42-46. Epub 2011 Jan 10.

[Autochthonous Hepatitis E-Virus Infection as Cause of Acute Hepatitis in

Germany - a Case Report.]

[Article in German]

Veitt R, Reichardt M, Wenzel J, Jilg W.

Klinik für Innere Medizin I, Kreiskrankenhaus Schmalkalden.

Abstract

There is an increasing body of evidence that hepatitis E virus (HEV) triggers

acute hepatitis not only in tropical and subtropical regions of Asia, Africa,

and America with low sanitary standards but also in highly industrialized

countries. We here report on two patients from Thuringia (Germany) with a HEV

infection without a recent stay abroad. All other common causes of hepatitis

were excluded. Transaminases were significantly incresed in both cases, while

icterus could be proven in one patient, only. Both patients fully recovered in

the long-term course. Epidemiological and phylogenetic data from viral analyses

suggest that HEV infection has to be considered as a zoonosis. It is likely that

viral transmission from animals to humans occurs through insufficiently cooked

meat or entrails, e. g., from pigs or wild animals. In summary, HEV infection is

a relevant differential diagnosis in acute non-A/B/C viral hepatitis. Further

studies are required for the identification of other transmission pathways,

pathogen reservoirs as well as novel concepts for prophylaxis, especially for

patients at risk for hepatic diseases.© Georg Thieme Verlag KG Stuttgart · New

York.

PMID: 21225537 [PubMed - as supplied by publisher]

[Guest guest]

Z Gastroenterol. 2011 Jan;49(1):42-46. Epub 2011 Jan 10.

[Autochthonous Hepatitis E-Virus Infection as Cause of Acute Hepatitis in

Germany - a Case Report.]

[Article in German]

Veitt R, Reichardt M, Wenzel J, Jilg W.

Klinik für Innere Medizin I, Kreiskrankenhaus Schmalkalden.

Abstract

There is an increasing body of evidence that hepatitis E virus (HEV) triggers

acute hepatitis not only in tropical and subtropical regions of Asia, Africa,

and America with low sanitary standards but also in highly industrialized

countries. We here report on two patients from Thuringia (Germany) with a HEV

infection without a recent stay abroad. All other common causes of hepatitis

were excluded. Transaminases were significantly incresed in both cases, while

icterus could be proven in one patient, only. Both patients fully recovered in

the long-term course. Epidemiological and phylogenetic data from viral analyses

suggest that HEV infection has to be considered as a zoonosis. It is likely that

viral transmission from animals to humans occurs through insufficiently cooked

meat or entrails, e. g., from pigs or wild animals. In summary, HEV infection is

a relevant differential diagnosis in acute non-A/B/C viral hepatitis. Further

studies are required for the identification of other transmission pathways,

pathogen reservoirs as well as novel concepts for prophylaxis, especially for

patients at risk for hepatic diseases.© Georg Thieme Verlag KG Stuttgart · New

York.

PMID: 21225537 [PubMed - as supplied by publisher]