Effective hepatic artery chemoembolization for advanced hepatocellular carcinoma with extensive tumour thrombus through the hepatic vein

[Guest guest]

Journal of Gastroenterology and Hepatology 14 922-927

© Blackwell Science Asia Pty. Ltd.

HEPATOCELLULAR CARCINOMA

Effective hepatic artery chemoembolization for advanced hepatocellular

carcinoma with extensive tumour thrombus through the hepatic vein

Yasushige Kashima, Masaru Miyazaki, Hiroshi Ito, Takashi Kaiho, Koji

Nakagawa, Satoshi Ambiru, Hiroaki Shimizu, Seiji Furuya and Nobuyuki

Nakajima

Background and Aims: Advanced hepatocellular carcinoma (HCC) with extensive

tumour growth through the hepatic vein still has an extremely poor

prognosis, even after cancer chemotherapy and/or transarterial embolization.

Although aggressive surgical treatments using extracorporeal circulation and

liver transplantation have been performed by some authors, the reported

results were still unsatisfactory. In this study, we report the favourable

result of hepatic artery chemoembolization and subsequent surgical resection

in three patients with advanced HCC with extensive tumour thrombus through

the hepatic vein.

Methods and Results: Three irresectable patients with HCC with extensive

tumour thrombus through the hepatic vein underwent hepatic artery

chemoembolization with aclarubicin, mitomycin C, lipiodol and/or Gelfoam.

After the reduction of tumour extent with hepatic artery chemoembolization,

two of the three patients underwent surgical resection. These two patients

are still alive at 59 and 21 postoperative months, respectively. In the

other case, the extent of the tumour and functional reserve of the liver

prevented us from performing surgical resection, but the patient is doing

well 62 months after the initial treatment.

Conclusions: Hepatic artery chemoembolization with aclarubicin, mitomycin C,

lipiodol and/or Gelfoam might be an effective treatment for irresectable

advanced HCC with extensive tumour thrombus into the inferior vena cava or

the right atrium through the hepatic vein. Radical surgical resection might

be applicable for selected patients without high surgical risk after

reducing tumour extent by hepatic artery chemoembolization.

© 1999 Blackwell Science Asia Pty Ltd

------------------------

[Guest guest]

Journal of Gastroenterology and Hepatology 14 922-927

© Blackwell Science Asia Pty. Ltd.

HEPATOCELLULAR CARCINOMA

Effective hepatic artery chemoembolization for advanced hepatocellular

carcinoma with extensive tumour thrombus through the hepatic vein

Yasushige Kashima, Masaru Miyazaki, Hiroshi Ito, Takashi Kaiho, Koji

Nakagawa, Satoshi Ambiru, Hiroaki Shimizu, Seiji Furuya and Nobuyuki

Nakajima

Background and Aims: Advanced hepatocellular carcinoma (HCC) with extensive

tumour growth through the hepatic vein still has an extremely poor

prognosis, even after cancer chemotherapy and/or transarterial embolization.

Although aggressive surgical treatments using extracorporeal circulation and

liver transplantation have been performed by some authors, the reported

results were still unsatisfactory. In this study, we report the favourable

result of hepatic artery chemoembolization and subsequent surgical resection

in three patients with advanced HCC with extensive tumour thrombus through

the hepatic vein.

Methods and Results: Three irresectable patients with HCC with extensive

tumour thrombus through the hepatic vein underwent hepatic artery

chemoembolization with aclarubicin, mitomycin C, lipiodol and/or Gelfoam.

After the reduction of tumour extent with hepatic artery chemoembolization,

two of the three patients underwent surgical resection. These two patients

are still alive at 59 and 21 postoperative months, respectively. In the

other case, the extent of the tumour and functional reserve of the liver

prevented us from performing surgical resection, but the patient is doing

well 62 months after the initial treatment.

Conclusions: Hepatic artery chemoembolization with aclarubicin, mitomycin C,

lipiodol and/or Gelfoam might be an effective treatment for irresectable

advanced HCC with extensive tumour thrombus into the inferior vena cava or

the right atrium through the hepatic vein. Radical surgical resection might

be applicable for selected patients without high surgical risk after

reducing tumour extent by hepatic artery chemoembolization.

© 1999 Blackwell Science Asia Pty Ltd

------------------------

[Guest guest]

Journal of Gastroenterology and Hepatology 14 922-927

© Blackwell Science Asia Pty. Ltd.

HEPATOCELLULAR CARCINOMA

Effective hepatic artery chemoembolization for advanced hepatocellular

carcinoma with extensive tumour thrombus through the hepatic vein

Yasushige Kashima, Masaru Miyazaki, Hiroshi Ito, Takashi Kaiho, Koji

Nakagawa, Satoshi Ambiru, Hiroaki Shimizu, Seiji Furuya and Nobuyuki

Nakajima

Background and Aims: Advanced hepatocellular carcinoma (HCC) with extensive

tumour growth through the hepatic vein still has an extremely poor

prognosis, even after cancer chemotherapy and/or transarterial embolization.

Although aggressive surgical treatments using extracorporeal circulation and

liver transplantation have been performed by some authors, the reported

results were still unsatisfactory. In this study, we report the favourable

result of hepatic artery chemoembolization and subsequent surgical resection

in three patients with advanced HCC with extensive tumour thrombus through

the hepatic vein.

Methods and Results: Three irresectable patients with HCC with extensive

tumour thrombus through the hepatic vein underwent hepatic artery

chemoembolization with aclarubicin, mitomycin C, lipiodol and/or Gelfoam.

After the reduction of tumour extent with hepatic artery chemoembolization,

two of the three patients underwent surgical resection. These two patients

are still alive at 59 and 21 postoperative months, respectively. In the

other case, the extent of the tumour and functional reserve of the liver

prevented us from performing surgical resection, but the patient is doing

well 62 months after the initial treatment.

Conclusions: Hepatic artery chemoembolization with aclarubicin, mitomycin C,

lipiodol and/or Gelfoam might be an effective treatment for irresectable

advanced HCC with extensive tumour thrombus into the inferior vena cava or

the right atrium through the hepatic vein. Radical surgical resection might

be applicable for selected patients without high surgical risk after

reducing tumour extent by hepatic artery chemoembolization.

© 1999 Blackwell Science Asia Pty Ltd

------------------------

[Guest guest]

Journal of Gastroenterology and Hepatology 14 922-927

© Blackwell Science Asia Pty. Ltd.

HEPATOCELLULAR CARCINOMA

Effective hepatic artery chemoembolization for advanced hepatocellular

carcinoma with extensive tumour thrombus through the hepatic vein

Yasushige Kashima, Masaru Miyazaki, Hiroshi Ito, Takashi Kaiho, Koji

Nakagawa, Satoshi Ambiru, Hiroaki Shimizu, Seiji Furuya and Nobuyuki

Nakajima

Background and Aims: Advanced hepatocellular carcinoma (HCC) with extensive

tumour growth through the hepatic vein still has an extremely poor

prognosis, even after cancer chemotherapy and/or transarterial embolization.

Although aggressive surgical treatments using extracorporeal circulation and

liver transplantation have been performed by some authors, the reported

results were still unsatisfactory. In this study, we report the favourable

result of hepatic artery chemoembolization and subsequent surgical resection

in three patients with advanced HCC with extensive tumour thrombus through

the hepatic vein.

Methods and Results: Three irresectable patients with HCC with extensive

tumour thrombus through the hepatic vein underwent hepatic artery

chemoembolization with aclarubicin, mitomycin C, lipiodol and/or Gelfoam.

After the reduction of tumour extent with hepatic artery chemoembolization,

two of the three patients underwent surgical resection. These two patients

are still alive at 59 and 21 postoperative months, respectively. In the

other case, the extent of the tumour and functional reserve of the liver

prevented us from performing surgical resection, but the patient is doing

well 62 months after the initial treatment.

Conclusions: Hepatic artery chemoembolization with aclarubicin, mitomycin C,

lipiodol and/or Gelfoam might be an effective treatment for irresectable

advanced HCC with extensive tumour thrombus into the inferior vena cava or

the right atrium through the hepatic vein. Radical surgical resection might

be applicable for selected patients without high surgical risk after

reducing tumour extent by hepatic artery chemoembolization.

© 1999 Blackwell Science Asia Pty Ltd

------------------------