Selecting a marginal donor in liver transplantation (LT) remains controversial but is necessary because of the small number of available donors

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http://www.jmedicalcasereports.com/content/5/1/276/abstract

Case report

Living donor liver transplantation from a donor previously treated with

interferon for hepatitis C virus: a case report

Masaaki Hidaka, Mitsuhisa Takatsuki, Akihiko Soyama, Hisamitsu Miyaaki, Tatsuki

Ichikawa, Kazuhiko Nakao, Takashi Kanematsu and Susumu Eguchi

For all author emails, please log on.

Journal of Medical Case Reports 2011, 5:276 doi:10.1186/1752-1947-5-276

Published: 3 July 2011

Abstract (provisional)

Introduction

Selecting a marginal donor in liver transplantation (LT) remains controversial

but is necessary because of the small number of available donors.

Case presentation

A 46-year-old Japanese woman was a candidate to donate her liver to her brother,

who had decompensated liver cirrhosis of unknown origin. Eight years before the

donation, she had a mild liver dysfunction that was diagnosed as a hepatitis C

virus (HCV) infection (serotype 2). She had received anti-viral therapy with

interferon -2b three times weekly for 24 weeks and had a sustained viral

response (SVR). A biopsy of her liver before the donation showed normal findings

without any active hepatitis, and her serum was negative for HCV-RNA. Only 67

patients have undergone LT from a cadaveric donor in Japan. The family in this

case decided to have living donor LT. A careful selection for the liver graft

donation was made; however, since she was the only candidate, we approved her as

a living donor. She was discharged nine days after the liver donation. Her liver

function recovered immediately. A computed tomography scan showed sufficient

liver regeneration one year later. Her brother also had good liver function

after LT and had no HCV infection 48 months after surgery and no de novo

malignancy. Neither of the siblings has developed an HCV infection.

Conclusions

A patient with SVR status after interferon therapy might be considered a

candidate for living donor LT but only if there are no other possibilities of LT

for the recipient. A careful follow-up of the donor after donation is needed.

The recipient also must have a very close follow-up because it is difficult to

predict what might happen to the graft with post-transplant immunosuppression.

The complete article is available as a provisional PDF. The fully formatted PDF

and HTML versions are in production.

[Guest guest]

http://www.jmedicalcasereports.com/content/5/1/276/abstract

Case report

Living donor liver transplantation from a donor previously treated with

interferon for hepatitis C virus: a case report

Masaaki Hidaka, Mitsuhisa Takatsuki, Akihiko Soyama, Hisamitsu Miyaaki, Tatsuki

Ichikawa, Kazuhiko Nakao, Takashi Kanematsu and Susumu Eguchi

For all author emails, please log on.

Journal of Medical Case Reports 2011, 5:276 doi:10.1186/1752-1947-5-276

Published: 3 July 2011

Abstract (provisional)

Introduction

Selecting a marginal donor in liver transplantation (LT) remains controversial

but is necessary because of the small number of available donors.

Case presentation

A 46-year-old Japanese woman was a candidate to donate her liver to her brother,

who had decompensated liver cirrhosis of unknown origin. Eight years before the

donation, she had a mild liver dysfunction that was diagnosed as a hepatitis C

virus (HCV) infection (serotype 2). She had received anti-viral therapy with

interferon -2b three times weekly for 24 weeks and had a sustained viral

response (SVR). A biopsy of her liver before the donation showed normal findings

without any active hepatitis, and her serum was negative for HCV-RNA. Only 67

patients have undergone LT from a cadaveric donor in Japan. The family in this

case decided to have living donor LT. A careful selection for the liver graft

donation was made; however, since she was the only candidate, we approved her as

a living donor. She was discharged nine days after the liver donation. Her liver

function recovered immediately. A computed tomography scan showed sufficient

liver regeneration one year later. Her brother also had good liver function

after LT and had no HCV infection 48 months after surgery and no de novo

malignancy. Neither of the siblings has developed an HCV infection.

Conclusions

A patient with SVR status after interferon therapy might be considered a

candidate for living donor LT but only if there are no other possibilities of LT

for the recipient. A careful follow-up of the donor after donation is needed.

The recipient also must have a very close follow-up because it is difficult to

predict what might happen to the graft with post-transplant immunosuppression.

The complete article is available as a provisional PDF. The fully formatted PDF

and HTML versions are in production.

[Guest guest]

http://www.jmedicalcasereports.com/content/5/1/276/abstract

Case report

Living donor liver transplantation from a donor previously treated with

interferon for hepatitis C virus: a case report

Masaaki Hidaka, Mitsuhisa Takatsuki, Akihiko Soyama, Hisamitsu Miyaaki, Tatsuki

Ichikawa, Kazuhiko Nakao, Takashi Kanematsu and Susumu Eguchi

For all author emails, please log on.

Journal of Medical Case Reports 2011, 5:276 doi:10.1186/1752-1947-5-276

Published: 3 July 2011

Abstract (provisional)

Introduction

Selecting a marginal donor in liver transplantation (LT) remains controversial

but is necessary because of the small number of available donors.

Case presentation

A 46-year-old Japanese woman was a candidate to donate her liver to her brother,

who had decompensated liver cirrhosis of unknown origin. Eight years before the

donation, she had a mild liver dysfunction that was diagnosed as a hepatitis C

virus (HCV) infection (serotype 2). She had received anti-viral therapy with

interferon -2b three times weekly for 24 weeks and had a sustained viral

response (SVR). A biopsy of her liver before the donation showed normal findings

without any active hepatitis, and her serum was negative for HCV-RNA. Only 67

patients have undergone LT from a cadaveric donor in Japan. The family in this

case decided to have living donor LT. A careful selection for the liver graft

donation was made; however, since she was the only candidate, we approved her as

a living donor. She was discharged nine days after the liver donation. Her liver

function recovered immediately. A computed tomography scan showed sufficient

liver regeneration one year later. Her brother also had good liver function

after LT and had no HCV infection 48 months after surgery and no de novo

malignancy. Neither of the siblings has developed an HCV infection.

Conclusions

A patient with SVR status after interferon therapy might be considered a

candidate for living donor LT but only if there are no other possibilities of LT

for the recipient. A careful follow-up of the donor after donation is needed.

The recipient also must have a very close follow-up because it is difficult to

predict what might happen to the graft with post-transplant immunosuppression.

The complete article is available as a provisional PDF. The fully formatted PDF

and HTML versions are in production.

[Guest guest]

http://www.jmedicalcasereports.com/content/5/1/276/abstract

Case report

Living donor liver transplantation from a donor previously treated with

interferon for hepatitis C virus: a case report

Masaaki Hidaka, Mitsuhisa Takatsuki, Akihiko Soyama, Hisamitsu Miyaaki, Tatsuki

Ichikawa, Kazuhiko Nakao, Takashi Kanematsu and Susumu Eguchi

For all author emails, please log on.

Journal of Medical Case Reports 2011, 5:276 doi:10.1186/1752-1947-5-276

Published: 3 July 2011

Abstract (provisional)

Introduction

Selecting a marginal donor in liver transplantation (LT) remains controversial

but is necessary because of the small number of available donors.

Case presentation

A 46-year-old Japanese woman was a candidate to donate her liver to her brother,

who had decompensated liver cirrhosis of unknown origin. Eight years before the

donation, she had a mild liver dysfunction that was diagnosed as a hepatitis C

virus (HCV) infection (serotype 2). She had received anti-viral therapy with

interferon -2b three times weekly for 24 weeks and had a sustained viral

response (SVR). A biopsy of her liver before the donation showed normal findings

without any active hepatitis, and her serum was negative for HCV-RNA. Only 67

patients have undergone LT from a cadaveric donor in Japan. The family in this

case decided to have living donor LT. A careful selection for the liver graft

donation was made; however, since she was the only candidate, we approved her as

a living donor. She was discharged nine days after the liver donation. Her liver

function recovered immediately. A computed tomography scan showed sufficient

liver regeneration one year later. Her brother also had good liver function

after LT and had no HCV infection 48 months after surgery and no de novo

malignancy. Neither of the siblings has developed an HCV infection.

Conclusions

A patient with SVR status after interferon therapy might be considered a

candidate for living donor LT but only if there are no other possibilities of LT

for the recipient. A careful follow-up of the donor after donation is needed.

The recipient also must have a very close follow-up because it is difficult to

predict what might happen to the graft with post-transplant immunosuppression.

The complete article is available as a provisional PDF. The fully formatted PDF

and HTML versions are in production.