The insulin-like growth factor axis and risk of liver disease in hepatitis C virus/HIV-co-infected w

[Guest guest]

The insulin-like growth factor axis and risk of liver disease in hepatitis C

virus/HIV-co-infected women.

EPIDEMIOLOGY AND SOCIAL

AIDS. 22(4):527-531, February 19, 2008.

Strickler, D a; , A a; s, n b; Fazzari, a;

Yu, Herbert c; Augenbraun, d; French, Audrey L e; Young, f; Gange,

g; Anastos, a; Kovacs, h,*

Abstract:

Objective: Insulin-like growth factor (IGF) I stimulates the proliferation of

hepatic stellate cells (HSC), the primary source of extracellular matrix

accumulation in liver fibrosis. In contrast, insulin-like growth factor binding

protein (IGFBP) 3, the most abundant IGFBP in circulation, negatively modulates

HSC mitogenesis. To investigate the role of the IGF axis in hepatitis C virus

(HCV)-related liver disease among high-risk patients, we prospectively evaluated

HCV-viremic/HIV-positive women.

Design: A cohort investigation.

Methods: Total IGF-I and IGFBP-3 were measured in baseline serum specimens

obtained from 472 HCV-viremic/HIV-positive subjects enrolled in the Women's

Interagency HIV Study, a large multi-institutional cohort. The aspartate

aminotransferase to platelet ratio index (APRI), a marker of liver fibrosis, was

assessed annually.

Results: Normal APRI levels (< 1.0) at baseline were detected in 374 of the 472

HCV-viremic/HIV-positive subjects tested, of whom 302 had complete liver

function test data and were studied. IGF-I was positively associated [adjusted

odds ratio comparing the highest and lowest quartiles (AORq4-q1), 5.83; 95%

confidence interval (CI) 1.17-29.1; Ptrend = 0.03], and IGFBP-3 was inversely

associated (AORq4-q1, 0.13; 95% CI 0.02-0.76; Ptrend = 0.04), with subsequent

(incident) detection of an elevated APRI level (> 1.5), after adjustment for the

CD4 T-cell count, alcohol consumption, and other risk factors.

Conclusion: High IGF-I may be associated with increased risk and high IGFBP-3

with reduced risk of liver disease among HCV-viremic/HIV-positive women.

http://www.aidsonline.com/pt/re/aids/abstract.00002030-200802190-00011.htm;jsess\

ionid=H12TGGGc4YPYTjGdk0Fr5C8KBRGvYMlyynC05k1LmvYnGr032DlS!-383192544!181195628!\

8091!-1

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[Guest guest]

The insulin-like growth factor axis and risk of liver disease in hepatitis C

virus/HIV-co-infected women.

EPIDEMIOLOGY AND SOCIAL

AIDS. 22(4):527-531, February 19, 2008.

Strickler, D a; , A a; s, n b; Fazzari, a;

Yu, Herbert c; Augenbraun, d; French, Audrey L e; Young, f; Gange,

g; Anastos, a; Kovacs, h,*

Abstract:

Objective: Insulin-like growth factor (IGF) I stimulates the proliferation of

hepatic stellate cells (HSC), the primary source of extracellular matrix

accumulation in liver fibrosis. In contrast, insulin-like growth factor binding

protein (IGFBP) 3, the most abundant IGFBP in circulation, negatively modulates

HSC mitogenesis. To investigate the role of the IGF axis in hepatitis C virus

(HCV)-related liver disease among high-risk patients, we prospectively evaluated

HCV-viremic/HIV-positive women.

Design: A cohort investigation.

Methods: Total IGF-I and IGFBP-3 were measured in baseline serum specimens

obtained from 472 HCV-viremic/HIV-positive subjects enrolled in the Women's

Interagency HIV Study, a large multi-institutional cohort. The aspartate

aminotransferase to platelet ratio index (APRI), a marker of liver fibrosis, was

assessed annually.

Results: Normal APRI levels (< 1.0) at baseline were detected in 374 of the 472

HCV-viremic/HIV-positive subjects tested, of whom 302 had complete liver

function test data and were studied. IGF-I was positively associated [adjusted

odds ratio comparing the highest and lowest quartiles (AORq4-q1), 5.83; 95%

confidence interval (CI) 1.17-29.1; Ptrend = 0.03], and IGFBP-3 was inversely

associated (AORq4-q1, 0.13; 95% CI 0.02-0.76; Ptrend = 0.04), with subsequent

(incident) detection of an elevated APRI level (> 1.5), after adjustment for the

CD4 T-cell count, alcohol consumption, and other risk factors.

Conclusion: High IGF-I may be associated with increased risk and high IGFBP-3

with reduced risk of liver disease among HCV-viremic/HIV-positive women.

http://www.aidsonline.com/pt/re/aids/abstract.00002030-200802190-00011.htm;jsess\

ionid=H12TGGGc4YPYTjGdk0Fr5C8KBRGvYMlyynC05k1LmvYnGr032DlS!-383192544!181195628!\

8091!-1

_________________________________________________________________

Helping your favorite cause is as easy as instant messaging. You IM, we give.

http://im.live.com/Messenger/IM/Home/?source=text_hotmail_join

[Guest guest]

The insulin-like growth factor axis and risk of liver disease in hepatitis C

virus/HIV-co-infected women.

EPIDEMIOLOGY AND SOCIAL

AIDS. 22(4):527-531, February 19, 2008.

Strickler, D a; , A a; s, n b; Fazzari, a;

Yu, Herbert c; Augenbraun, d; French, Audrey L e; Young, f; Gange,

g; Anastos, a; Kovacs, h,*

Abstract:

Objective: Insulin-like growth factor (IGF) I stimulates the proliferation of

hepatic stellate cells (HSC), the primary source of extracellular matrix

accumulation in liver fibrosis. In contrast, insulin-like growth factor binding

protein (IGFBP) 3, the most abundant IGFBP in circulation, negatively modulates

HSC mitogenesis. To investigate the role of the IGF axis in hepatitis C virus

(HCV)-related liver disease among high-risk patients, we prospectively evaluated

HCV-viremic/HIV-positive women.

Design: A cohort investigation.

Methods: Total IGF-I and IGFBP-3 were measured in baseline serum specimens

obtained from 472 HCV-viremic/HIV-positive subjects enrolled in the Women's

Interagency HIV Study, a large multi-institutional cohort. The aspartate

aminotransferase to platelet ratio index (APRI), a marker of liver fibrosis, was

assessed annually.

Results: Normal APRI levels (< 1.0) at baseline were detected in 374 of the 472

HCV-viremic/HIV-positive subjects tested, of whom 302 had complete liver

function test data and were studied. IGF-I was positively associated [adjusted

odds ratio comparing the highest and lowest quartiles (AORq4-q1), 5.83; 95%

confidence interval (CI) 1.17-29.1; Ptrend = 0.03], and IGFBP-3 was inversely

associated (AORq4-q1, 0.13; 95% CI 0.02-0.76; Ptrend = 0.04), with subsequent

(incident) detection of an elevated APRI level (> 1.5), after adjustment for the

CD4 T-cell count, alcohol consumption, and other risk factors.

Conclusion: High IGF-I may be associated with increased risk and high IGFBP-3

with reduced risk of liver disease among HCV-viremic/HIV-positive women.

http://www.aidsonline.com/pt/re/aids/abstract.00002030-200802190-00011.htm;jsess\

ionid=H12TGGGc4YPYTjGdk0Fr5C8KBRGvYMlyynC05k1LmvYnGr032DlS!-383192544!181195628!\

8091!-1

_________________________________________________________________

Helping your favorite cause is as easy as instant messaging. You IM, we give.

http://im.live.com/Messenger/IM/Home/?source=text_hotmail_join

[Guest guest]

The insulin-like growth factor axis and risk of liver disease in hepatitis C

virus/HIV-co-infected women.

EPIDEMIOLOGY AND SOCIAL

AIDS. 22(4):527-531, February 19, 2008.

Strickler, D a; , A a; s, n b; Fazzari, a;

Yu, Herbert c; Augenbraun, d; French, Audrey L e; Young, f; Gange,

g; Anastos, a; Kovacs, h,*

Abstract:

Objective: Insulin-like growth factor (IGF) I stimulates the proliferation of

hepatic stellate cells (HSC), the primary source of extracellular matrix

accumulation in liver fibrosis. In contrast, insulin-like growth factor binding

protein (IGFBP) 3, the most abundant IGFBP in circulation, negatively modulates

HSC mitogenesis. To investigate the role of the IGF axis in hepatitis C virus

(HCV)-related liver disease among high-risk patients, we prospectively evaluated

HCV-viremic/HIV-positive women.

Design: A cohort investigation.

Methods: Total IGF-I and IGFBP-3 were measured in baseline serum specimens

obtained from 472 HCV-viremic/HIV-positive subjects enrolled in the Women's

Interagency HIV Study, a large multi-institutional cohort. The aspartate

aminotransferase to platelet ratio index (APRI), a marker of liver fibrosis, was

assessed annually.

Results: Normal APRI levels (< 1.0) at baseline were detected in 374 of the 472

HCV-viremic/HIV-positive subjects tested, of whom 302 had complete liver

function test data and were studied. IGF-I was positively associated [adjusted

odds ratio comparing the highest and lowest quartiles (AORq4-q1), 5.83; 95%

confidence interval (CI) 1.17-29.1; Ptrend = 0.03], and IGFBP-3 was inversely

associated (AORq4-q1, 0.13; 95% CI 0.02-0.76; Ptrend = 0.04), with subsequent

(incident) detection of an elevated APRI level (> 1.5), after adjustment for the

CD4 T-cell count, alcohol consumption, and other risk factors.

Conclusion: High IGF-I may be associated with increased risk and high IGFBP-3

with reduced risk of liver disease among HCV-viremic/HIV-positive women.

http://www.aidsonline.com/pt/re/aids/abstract.00002030-200802190-00011.htm;jsess\

ionid=H12TGGGc4YPYTjGdk0Fr5C8KBRGvYMlyynC05k1LmvYnGr032DlS!-383192544!181195628!\

8091!-1

_________________________________________________________________

Helping your favorite cause is as easy as instant messaging. You IM, we give.

http://im.live.com/Messenger/IM/Home/?source=text_hotmail_join