Hepatitis B surface antigen confirmatory testing for diagnosis of hepatitis b virus infection in Taiwan.

[Guest guest]

http://www.ncbi.nlm.nih.gov/pubmed/21739440

J Med Virol. 2011 Sep;83(9):1514-21. doi: 10.1002/jmv.22127.

Hepatitis B surface antigen confirmatory testing for diagnosis of hepatitis b

virus infection in Taiwan.

Chu FY, Su FH, Cheng SH, Lin YS, Li CY, Chien CC, Lin YC, Chiang SY.

Source

Department of Clinical Pathology, Far Eastern Memorial Hospital, New Taipei

City, Taiwan; Department of Medical Laboratory Science and Biotechnology,

Yuanpei University, Hsinchu, Taiwan. jacphajacpha@....

Abstract

This study aimed to examine the application of hepatitis B surface antigen

(HBsAg) confirmatory testing when diagnosing hepatitis B infection among young

persons in Taiwan with a low prevalence rate of hepatitis B infection. HBsAg

status, the presence of antibodies against HBsAg (anti-HBs), and the presence of

antibodies against hepatitis B core antigen (anti-HBc) were compared among 403

graduate students (mean age 22.8 ± 0.7 years) and 1,745 undergraduate

students (18.6 ± 1.0 years) from one university, and 367 adult subjects

(41.1 ± 15.8 years) in 2008. Any HBsAg-positive subjects were tested with

an HBsAg confirmatory test. Chi-square tests for trend and predictive values of

positivity (PVP) when using HBsAg-positive only for determining confirmed cases

of hepatitis B infection were compared across the three cohorts. The prevalence

of HBsAg positivity among subjects decreased from 16.3% in the adults to 5.2% in

the graduate students and then to 2.8% for the undergraduate students

(P = 0.0007). The PVP of HBsAg testing when determining cases of hepatitis B

decreased from 0.97 for the adults to 0.81 for the graduate students and then to

0.56 for the undergraduate students (P < 0.0001). Thus, a significant

decrease in the true-positive rate of HBsAg among the students born after the

introduction of hepatitis B vaccination was observed only when HBsAg testing was

applied. Additional neutralization tests may therefore become mandatory for

persons with a positive HBsAg test result who were born after the commencement

of the universal neonatal hepatitis B vaccination program in Taiwan. J. Med.

Virol. 83:1514-1521, 2011. © 2011 Wiley-Liss, Inc.

Copyright © 2011 Wiley-Liss, Inc.

PMID: 21739440 [PubMed - in process]

[Guest guest]

http://www.ncbi.nlm.nih.gov/pubmed/21739440

J Med Virol. 2011 Sep;83(9):1514-21. doi: 10.1002/jmv.22127.

Hepatitis B surface antigen confirmatory testing for diagnosis of hepatitis b

virus infection in Taiwan.

Chu FY, Su FH, Cheng SH, Lin YS, Li CY, Chien CC, Lin YC, Chiang SY.

Source

Department of Clinical Pathology, Far Eastern Memorial Hospital, New Taipei

City, Taiwan; Department of Medical Laboratory Science and Biotechnology,

Yuanpei University, Hsinchu, Taiwan. jacphajacpha@....

Abstract

This study aimed to examine the application of hepatitis B surface antigen

(HBsAg) confirmatory testing when diagnosing hepatitis B infection among young

persons in Taiwan with a low prevalence rate of hepatitis B infection. HBsAg

status, the presence of antibodies against HBsAg (anti-HBs), and the presence of

antibodies against hepatitis B core antigen (anti-HBc) were compared among 403

graduate students (mean age 22.8 ± 0.7 years) and 1,745 undergraduate

students (18.6 ± 1.0 years) from one university, and 367 adult subjects

(41.1 ± 15.8 years) in 2008. Any HBsAg-positive subjects were tested with

an HBsAg confirmatory test. Chi-square tests for trend and predictive values of

positivity (PVP) when using HBsAg-positive only for determining confirmed cases

of hepatitis B infection were compared across the three cohorts. The prevalence

of HBsAg positivity among subjects decreased from 16.3% in the adults to 5.2% in

the graduate students and then to 2.8% for the undergraduate students

(P = 0.0007). The PVP of HBsAg testing when determining cases of hepatitis B

decreased from 0.97 for the adults to 0.81 for the graduate students and then to

0.56 for the undergraduate students (P < 0.0001). Thus, a significant

decrease in the true-positive rate of HBsAg among the students born after the

introduction of hepatitis B vaccination was observed only when HBsAg testing was

applied. Additional neutralization tests may therefore become mandatory for

persons with a positive HBsAg test result who were born after the commencement

of the universal neonatal hepatitis B vaccination program in Taiwan. J. Med.

Virol. 83:1514-1521, 2011. © 2011 Wiley-Liss, Inc.

Copyright © 2011 Wiley-Liss, Inc.

PMID: 21739440 [PubMed - in process]

[Guest guest]

http://www.ncbi.nlm.nih.gov/pubmed/21739440

J Med Virol. 2011 Sep;83(9):1514-21. doi: 10.1002/jmv.22127.

Hepatitis B surface antigen confirmatory testing for diagnosis of hepatitis b

virus infection in Taiwan.

Chu FY, Su FH, Cheng SH, Lin YS, Li CY, Chien CC, Lin YC, Chiang SY.

Source

Department of Clinical Pathology, Far Eastern Memorial Hospital, New Taipei

City, Taiwan; Department of Medical Laboratory Science and Biotechnology,

Yuanpei University, Hsinchu, Taiwan. jacphajacpha@....

Abstract

This study aimed to examine the application of hepatitis B surface antigen

(HBsAg) confirmatory testing when diagnosing hepatitis B infection among young

persons in Taiwan with a low prevalence rate of hepatitis B infection. HBsAg

status, the presence of antibodies against HBsAg (anti-HBs), and the presence of

antibodies against hepatitis B core antigen (anti-HBc) were compared among 403

graduate students (mean age 22.8 ± 0.7 years) and 1,745 undergraduate

students (18.6 ± 1.0 years) from one university, and 367 adult subjects

(41.1 ± 15.8 years) in 2008. Any HBsAg-positive subjects were tested with

an HBsAg confirmatory test. Chi-square tests for trend and predictive values of

positivity (PVP) when using HBsAg-positive only for determining confirmed cases

of hepatitis B infection were compared across the three cohorts. The prevalence

of HBsAg positivity among subjects decreased from 16.3% in the adults to 5.2% in

the graduate students and then to 2.8% for the undergraduate students

(P = 0.0007). The PVP of HBsAg testing when determining cases of hepatitis B

decreased from 0.97 for the adults to 0.81 for the graduate students and then to

0.56 for the undergraduate students (P < 0.0001). Thus, a significant

decrease in the true-positive rate of HBsAg among the students born after the

introduction of hepatitis B vaccination was observed only when HBsAg testing was

applied. Additional neutralization tests may therefore become mandatory for

persons with a positive HBsAg test result who were born after the commencement

of the universal neonatal hepatitis B vaccination program in Taiwan. J. Med.

Virol. 83:1514-1521, 2011. © 2011 Wiley-Liss, Inc.

Copyright © 2011 Wiley-Liss, Inc.

PMID: 21739440 [PubMed - in process]

[Guest guest]

http://www.ncbi.nlm.nih.gov/pubmed/21739440

J Med Virol. 2011 Sep;83(9):1514-21. doi: 10.1002/jmv.22127.

Hepatitis B surface antigen confirmatory testing for diagnosis of hepatitis b

virus infection in Taiwan.

Chu FY, Su FH, Cheng SH, Lin YS, Li CY, Chien CC, Lin YC, Chiang SY.

Source

Department of Clinical Pathology, Far Eastern Memorial Hospital, New Taipei

City, Taiwan; Department of Medical Laboratory Science and Biotechnology,

Yuanpei University, Hsinchu, Taiwan. jacphajacpha@....

Abstract

This study aimed to examine the application of hepatitis B surface antigen

(HBsAg) confirmatory testing when diagnosing hepatitis B infection among young

persons in Taiwan with a low prevalence rate of hepatitis B infection. HBsAg

status, the presence of antibodies against HBsAg (anti-HBs), and the presence of

antibodies against hepatitis B core antigen (anti-HBc) were compared among 403

graduate students (mean age 22.8 ± 0.7 years) and 1,745 undergraduate

students (18.6 ± 1.0 years) from one university, and 367 adult subjects

(41.1 ± 15.8 years) in 2008. Any HBsAg-positive subjects were tested with

an HBsAg confirmatory test. Chi-square tests for trend and predictive values of

positivity (PVP) when using HBsAg-positive only for determining confirmed cases

of hepatitis B infection were compared across the three cohorts. The prevalence

of HBsAg positivity among subjects decreased from 16.3% in the adults to 5.2% in

the graduate students and then to 2.8% for the undergraduate students

(P = 0.0007). The PVP of HBsAg testing when determining cases of hepatitis B

decreased from 0.97 for the adults to 0.81 for the graduate students and then to

0.56 for the undergraduate students (P < 0.0001). Thus, a significant

decrease in the true-positive rate of HBsAg among the students born after the

introduction of hepatitis B vaccination was observed only when HBsAg testing was

applied. Additional neutralization tests may therefore become mandatory for

persons with a positive HBsAg test result who were born after the commencement

of the universal neonatal hepatitis B vaccination program in Taiwan. J. Med.

Virol. 83:1514-1521, 2011. © 2011 Wiley-Liss, Inc.

Copyright © 2011 Wiley-Liss, Inc.

PMID: 21739440 [PubMed - in process]