Evaluation of Risk Factors and Clinicopathologic Features for Intrahepatic Cholangiocarcinoma in Southern China: A Possible Role of Hepatitis B Virus

[Guest guest]

http://www.springerlink.com/content/y2p7j43gl452x063/

ls of Surgical Oncology

DOI: 10.1245/s10434-010-1458-5Online First™

Hepatobiliary Tumors

Evaluation of Risk Factors and Clinicopathologic Features for Intrahepatic

Cholangiocarcinoma in Southern China: A Possible Role of Hepatitis B Virus

Ning-fu Peng, Le-qun Li, Xiao Qin, Ya Guo, Tao Peng, Kai-yin Xiao, Xi-gang Chen,

Yu-feng Yang, Zhi-xiong Su and Bin Chen, et al.

Abstract

Background

Recent efforts suggest an etiologic role of hepatitis B virus (HBV) infection in

intrahepatic cholangiocarcinoma (ICC) and the involvement of hepatic progenitor

cell in ICC development, without definitive conclusions. This case-control study

was undertaken to investigate risk factors for ICC, and clinicopathological

features of HBV-associated ICC were analyzed.

Methods

The report comprised 98 patients with pathologically confirmed ICC and 196

healthy control subjects. Logistic regression was used to determine odds ratios

and 95% confidence intervals. The sex and age distributions of HBV-related and

unrelated ICC patients were compared respectively with those of 882

HBV-associated hepatocellular carcinoma patients from a random selection, and

the clinicopathological data of 62 ICC patients with or without HBV infection

undergoing surgical resection were compared.

Results

There was an association between ICC and each of HBV infection, liver cirrhosis,

hepatolithiasis, and liver fluke infestation with the odds ratios (95%

confidence intervals) of 2.75 (1.27–5.95), 8.42 (2.50–28.37), 22.81

(7.16–72.68), and 3.55 (1.60–7.89), respectively, with a marked synergism of

cirrhosis and HBV infection (20.67; 5.40–79.06). Compared with HBV-unrelated ICC

patients, HBV-related ICC patients were more common in male and younger

subjects, had a higher incidence of abnormal serum alfa-fetoprotein level,

cirrhosis, and neutrophilic infiltration, and had a lower proportion of elevated

carbohydrate antigen 19-9 (CA19-9) values.

Conclusions

The independent association of HBV infection with ICC, synergy between cirrhosis

and HBV infection, and some clinicopathological similarities between HBV-related

ICC and hepatocellular carcinoma suggests that both may share similar or common

tumorigenic process and may possibly originate from malignant transformation of

hepatic progenitor cell.

[Guest guest]

http://www.springerlink.com/content/y2p7j43gl452x063/

ls of Surgical Oncology

DOI: 10.1245/s10434-010-1458-5Online First™

Hepatobiliary Tumors

Evaluation of Risk Factors and Clinicopathologic Features for Intrahepatic

Cholangiocarcinoma in Southern China: A Possible Role of Hepatitis B Virus

Ning-fu Peng, Le-qun Li, Xiao Qin, Ya Guo, Tao Peng, Kai-yin Xiao, Xi-gang Chen,

Yu-feng Yang, Zhi-xiong Su and Bin Chen, et al.

Abstract

Background

Recent efforts suggest an etiologic role of hepatitis B virus (HBV) infection in

intrahepatic cholangiocarcinoma (ICC) and the involvement of hepatic progenitor

cell in ICC development, without definitive conclusions. This case-control study

was undertaken to investigate risk factors for ICC, and clinicopathological

features of HBV-associated ICC were analyzed.

Methods

The report comprised 98 patients with pathologically confirmed ICC and 196

healthy control subjects. Logistic regression was used to determine odds ratios

and 95% confidence intervals. The sex and age distributions of HBV-related and

unrelated ICC patients were compared respectively with those of 882

HBV-associated hepatocellular carcinoma patients from a random selection, and

the clinicopathological data of 62 ICC patients with or without HBV infection

undergoing surgical resection were compared.

Results

There was an association between ICC and each of HBV infection, liver cirrhosis,

hepatolithiasis, and liver fluke infestation with the odds ratios (95%

confidence intervals) of 2.75 (1.27–5.95), 8.42 (2.50–28.37), 22.81

(7.16–72.68), and 3.55 (1.60–7.89), respectively, with a marked synergism of

cirrhosis and HBV infection (20.67; 5.40–79.06). Compared with HBV-unrelated ICC

patients, HBV-related ICC patients were more common in male and younger

subjects, had a higher incidence of abnormal serum alfa-fetoprotein level,

cirrhosis, and neutrophilic infiltration, and had a lower proportion of elevated

carbohydrate antigen 19-9 (CA19-9) values.

Conclusions

The independent association of HBV infection with ICC, synergy between cirrhosis

and HBV infection, and some clinicopathological similarities between HBV-related

ICC and hepatocellular carcinoma suggests that both may share similar or common

tumorigenic process and may possibly originate from malignant transformation of

hepatic progenitor cell.

[Guest guest]

http://www.springerlink.com/content/y2p7j43gl452x063/

ls of Surgical Oncology

DOI: 10.1245/s10434-010-1458-5Online First™

Hepatobiliary Tumors

Evaluation of Risk Factors and Clinicopathologic Features for Intrahepatic

Cholangiocarcinoma in Southern China: A Possible Role of Hepatitis B Virus

Ning-fu Peng, Le-qun Li, Xiao Qin, Ya Guo, Tao Peng, Kai-yin Xiao, Xi-gang Chen,

Yu-feng Yang, Zhi-xiong Su and Bin Chen, et al.

Abstract

Background

Recent efforts suggest an etiologic role of hepatitis B virus (HBV) infection in

intrahepatic cholangiocarcinoma (ICC) and the involvement of hepatic progenitor

cell in ICC development, without definitive conclusions. This case-control study

was undertaken to investigate risk factors for ICC, and clinicopathological

features of HBV-associated ICC were analyzed.

Methods

The report comprised 98 patients with pathologically confirmed ICC and 196

healthy control subjects. Logistic regression was used to determine odds ratios

and 95% confidence intervals. The sex and age distributions of HBV-related and

unrelated ICC patients were compared respectively with those of 882

HBV-associated hepatocellular carcinoma patients from a random selection, and

the clinicopathological data of 62 ICC patients with or without HBV infection

undergoing surgical resection were compared.

Results

There was an association between ICC and each of HBV infection, liver cirrhosis,

hepatolithiasis, and liver fluke infestation with the odds ratios (95%

confidence intervals) of 2.75 (1.27–5.95), 8.42 (2.50–28.37), 22.81

(7.16–72.68), and 3.55 (1.60–7.89), respectively, with a marked synergism of

cirrhosis and HBV infection (20.67; 5.40–79.06). Compared with HBV-unrelated ICC

patients, HBV-related ICC patients were more common in male and younger

subjects, had a higher incidence of abnormal serum alfa-fetoprotein level,

cirrhosis, and neutrophilic infiltration, and had a lower proportion of elevated

carbohydrate antigen 19-9 (CA19-9) values.

Conclusions

The independent association of HBV infection with ICC, synergy between cirrhosis

and HBV infection, and some clinicopathological similarities between HBV-related

ICC and hepatocellular carcinoma suggests that both may share similar or common

tumorigenic process and may possibly originate from malignant transformation of

hepatic progenitor cell.

[Guest guest]

http://www.springerlink.com/content/y2p7j43gl452x063/

ls of Surgical Oncology

DOI: 10.1245/s10434-010-1458-5Online First™

Hepatobiliary Tumors

Evaluation of Risk Factors and Clinicopathologic Features for Intrahepatic

Cholangiocarcinoma in Southern China: A Possible Role of Hepatitis B Virus

Ning-fu Peng, Le-qun Li, Xiao Qin, Ya Guo, Tao Peng, Kai-yin Xiao, Xi-gang Chen,

Yu-feng Yang, Zhi-xiong Su and Bin Chen, et al.

Abstract

Background

Recent efforts suggest an etiologic role of hepatitis B virus (HBV) infection in

intrahepatic cholangiocarcinoma (ICC) and the involvement of hepatic progenitor

cell in ICC development, without definitive conclusions. This case-control study

was undertaken to investigate risk factors for ICC, and clinicopathological

features of HBV-associated ICC were analyzed.

Methods

The report comprised 98 patients with pathologically confirmed ICC and 196

healthy control subjects. Logistic regression was used to determine odds ratios

and 95% confidence intervals. The sex and age distributions of HBV-related and

unrelated ICC patients were compared respectively with those of 882

HBV-associated hepatocellular carcinoma patients from a random selection, and

the clinicopathological data of 62 ICC patients with or without HBV infection

undergoing surgical resection were compared.

Results

There was an association between ICC and each of HBV infection, liver cirrhosis,

hepatolithiasis, and liver fluke infestation with the odds ratios (95%

confidence intervals) of 2.75 (1.27–5.95), 8.42 (2.50–28.37), 22.81

(7.16–72.68), and 3.55 (1.60–7.89), respectively, with a marked synergism of

cirrhosis and HBV infection (20.67; 5.40–79.06). Compared with HBV-unrelated ICC

patients, HBV-related ICC patients were more common in male and younger

subjects, had a higher incidence of abnormal serum alfa-fetoprotein level,

cirrhosis, and neutrophilic infiltration, and had a lower proportion of elevated

carbohydrate antigen 19-9 (CA19-9) values.

Conclusions

The independent association of HBV infection with ICC, synergy between cirrhosis

and HBV infection, and some clinicopathological similarities between HBV-related

ICC and hepatocellular carcinoma suggests that both may share similar or common

tumorigenic process and may possibly originate from malignant transformation of

hepatic progenitor cell.