There were no differences in serum HBV DNA level between HBeAg-positive and HBeAg-negative chronic hepatitis B with same liver histological necroinflammation grade but differences among grades 1, 2, 3 and 4 apportioned by the same hepatic parenchyma

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2893.2011.01444.x/abstract

There were no differences in serum HBV DNA level between HBeAg-positive and

HBeAg-negative chronic hepatitis B with same liver histological

necroinflammation grade but differences among grades 1, 2, 3 and 4 apportioned

by the same hepatic parenchyma cell volume

W.-M. Ke1, S.-B. Xie1, X.-J. Li1, S.-Q. Zhang1, J. Lai1, Y.-N. Ye1, Z.-L. Gao1,

P.-J. Chen2

Article first published online: 24 MAR 2011

DOI: 10.1111/j.1365-2893.2011.01444.x

© 2011 Blackwell Publishing Ltd

Issue

Journal of Viral Hepatitis

Volume 18, Issue 9, pages 637–645, September 2011

Summary.  Hepatitis B virus (HBV) DNA levels and liver histological

necroinflammation grades are correlated with the antiviral efficacy. It is

necessary to clarify the relationship between HBV replication levels apportioned

by the same hepatic parenchyma cell volume and severity of liver histological

necroinflammation grades in both hepatitis B e antigen (HBeAg)-positive and

HBeAg-negative chronic hepatitis B. The serum HBV DNA levels apportioned by the

same hepatic parenchyma cell volume were compared between HBeAg-positive and

HBeAg-negative chronic hepatitis B as well as among liver histological

necroinflammation grades 1, 2, 3 and 4, respectively. There were no differences

in the serum HBV DNA levels between HBeAg-positive and HBeAg-negative chronic

hepatitis B as well as among liver histological necroinflammation grades 1, 2, 3

and 4. However, there were differences in the serum HBV DNA levels apportioned

by the same hepatic parenchyma cell volume among liver histological

necroinflammation grades 1, 2, 3 and 4 in both HBeAg-positive and HBeAg-negative

chronic hepatitis B, respectively. There were no differences in HBV DNA levels

with the same liver histological necroinflammation grade activated by HBV

wild-type and variant strains. After the differences in hepatic parenchyma cell

volume for HBV replication of the same liver histological necroinflammation

grade accompanied by different hepatic fibrosis stages were adjusted, the serum

HBV DNA level apportioned by the same hepatic parenchyma cell volume was

correlated with the severity of liver histological necroinflammation grade.

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2893.2011.01444.x/abstract

There were no differences in serum HBV DNA level between HBeAg-positive and

HBeAg-negative chronic hepatitis B with same liver histological

necroinflammation grade but differences among grades 1, 2, 3 and 4 apportioned

by the same hepatic parenchyma cell volume

W.-M. Ke1, S.-B. Xie1, X.-J. Li1, S.-Q. Zhang1, J. Lai1, Y.-N. Ye1, Z.-L. Gao1,

P.-J. Chen2

Article first published online: 24 MAR 2011

DOI: 10.1111/j.1365-2893.2011.01444.x

© 2011 Blackwell Publishing Ltd

Issue

Journal of Viral Hepatitis

Volume 18, Issue 9, pages 637–645, September 2011

Summary.  Hepatitis B virus (HBV) DNA levels and liver histological

necroinflammation grades are correlated with the antiviral efficacy. It is

necessary to clarify the relationship between HBV replication levels apportioned

by the same hepatic parenchyma cell volume and severity of liver histological

necroinflammation grades in both hepatitis B e antigen (HBeAg)-positive and

HBeAg-negative chronic hepatitis B. The serum HBV DNA levels apportioned by the

same hepatic parenchyma cell volume were compared between HBeAg-positive and

HBeAg-negative chronic hepatitis B as well as among liver histological

necroinflammation grades 1, 2, 3 and 4, respectively. There were no differences

in the serum HBV DNA levels between HBeAg-positive and HBeAg-negative chronic

hepatitis B as well as among liver histological necroinflammation grades 1, 2, 3

and 4. However, there were differences in the serum HBV DNA levels apportioned

by the same hepatic parenchyma cell volume among liver histological

necroinflammation grades 1, 2, 3 and 4 in both HBeAg-positive and HBeAg-negative

chronic hepatitis B, respectively. There were no differences in HBV DNA levels

with the same liver histological necroinflammation grade activated by HBV

wild-type and variant strains. After the differences in hepatic parenchyma cell

volume for HBV replication of the same liver histological necroinflammation

grade accompanied by different hepatic fibrosis stages were adjusted, the serum

HBV DNA level apportioned by the same hepatic parenchyma cell volume was

correlated with the severity of liver histological necroinflammation grade.

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2893.2011.01444.x/abstract

There were no differences in serum HBV DNA level between HBeAg-positive and

HBeAg-negative chronic hepatitis B with same liver histological

necroinflammation grade but differences among grades 1, 2, 3 and 4 apportioned

by the same hepatic parenchyma cell volume

W.-M. Ke1, S.-B. Xie1, X.-J. Li1, S.-Q. Zhang1, J. Lai1, Y.-N. Ye1, Z.-L. Gao1,

P.-J. Chen2

Article first published online: 24 MAR 2011

DOI: 10.1111/j.1365-2893.2011.01444.x

© 2011 Blackwell Publishing Ltd

Issue

Journal of Viral Hepatitis

Volume 18, Issue 9, pages 637–645, September 2011

Summary.  Hepatitis B virus (HBV) DNA levels and liver histological

necroinflammation grades are correlated with the antiviral efficacy. It is

necessary to clarify the relationship between HBV replication levels apportioned

by the same hepatic parenchyma cell volume and severity of liver histological

necroinflammation grades in both hepatitis B e antigen (HBeAg)-positive and

HBeAg-negative chronic hepatitis B. The serum HBV DNA levels apportioned by the

same hepatic parenchyma cell volume were compared between HBeAg-positive and

HBeAg-negative chronic hepatitis B as well as among liver histological

necroinflammation grades 1, 2, 3 and 4, respectively. There were no differences

in the serum HBV DNA levels between HBeAg-positive and HBeAg-negative chronic

hepatitis B as well as among liver histological necroinflammation grades 1, 2, 3

and 4. However, there were differences in the serum HBV DNA levels apportioned

by the same hepatic parenchyma cell volume among liver histological

necroinflammation grades 1, 2, 3 and 4 in both HBeAg-positive and HBeAg-negative

chronic hepatitis B, respectively. There were no differences in HBV DNA levels

with the same liver histological necroinflammation grade activated by HBV

wild-type and variant strains. After the differences in hepatic parenchyma cell

volume for HBV replication of the same liver histological necroinflammation

grade accompanied by different hepatic fibrosis stages were adjusted, the serum

HBV DNA level apportioned by the same hepatic parenchyma cell volume was

correlated with the severity of liver histological necroinflammation grade.

[Guest guest]

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2893.2011.01444.x/abstract

There were no differences in serum HBV DNA level between HBeAg-positive and

HBeAg-negative chronic hepatitis B with same liver histological

necroinflammation grade but differences among grades 1, 2, 3 and 4 apportioned

by the same hepatic parenchyma cell volume

W.-M. Ke1, S.-B. Xie1, X.-J. Li1, S.-Q. Zhang1, J. Lai1, Y.-N. Ye1, Z.-L. Gao1,

P.-J. Chen2

Article first published online: 24 MAR 2011

DOI: 10.1111/j.1365-2893.2011.01444.x

© 2011 Blackwell Publishing Ltd

Issue

Journal of Viral Hepatitis

Volume 18, Issue 9, pages 637–645, September 2011

Summary.  Hepatitis B virus (HBV) DNA levels and liver histological

necroinflammation grades are correlated with the antiviral efficacy. It is

necessary to clarify the relationship between HBV replication levels apportioned

by the same hepatic parenchyma cell volume and severity of liver histological

necroinflammation grades in both hepatitis B e antigen (HBeAg)-positive and

HBeAg-negative chronic hepatitis B. The serum HBV DNA levels apportioned by the

same hepatic parenchyma cell volume were compared between HBeAg-positive and

HBeAg-negative chronic hepatitis B as well as among liver histological

necroinflammation grades 1, 2, 3 and 4, respectively. There were no differences

in the serum HBV DNA levels between HBeAg-positive and HBeAg-negative chronic

hepatitis B as well as among liver histological necroinflammation grades 1, 2, 3

and 4. However, there were differences in the serum HBV DNA levels apportioned

by the same hepatic parenchyma cell volume among liver histological

necroinflammation grades 1, 2, 3 and 4 in both HBeAg-positive and HBeAg-negative

chronic hepatitis B, respectively. There were no differences in HBV DNA levels

with the same liver histological necroinflammation grade activated by HBV

wild-type and variant strains. After the differences in hepatic parenchyma cell

volume for HBV replication of the same liver histological necroinflammation

grade accompanied by different hepatic fibrosis stages were adjusted, the serum

HBV DNA level apportioned by the same hepatic parenchyma cell volume was

correlated with the severity of liver histological necroinflammation grade.