Liver transplantation for hepatocellular carcinoma in children

January 7, 2008

Pediatric Transplantation 12 (1), 52–56.

doi:10.1111/j.1399-3046.2007.00777.x

Abstract

Liver transplantation for hepatocellular carcinoma in children

Sinasi Sevmis11Departments of General Surgery and Transplantation, Hamdi

Karakayali11Departments of General Surgery and Transplantation, Figen

Özçay33Pediatric Gastroenterology, Oðuz Canan33Pediatric Gastroenterology, Banu

Bilezikci44Pathology, Baskent University Faculty of Medicine, Ankara, Turkey,

Adnan Torgay22Anesthesiology and Mehmet Haberal11Departments of General Surgery

and Transplantation1Departments of General Surgery and Transplantation,

2Anesthesiology, 3Pediatric Gastroenterology and 4Pathology, Baskent University

Faculty of Medicine, Ankara, Turkey

Mehmet Haberal, Baskent University Faculty of Medicine, 1. Cad. No: 77, Kat: 4

Bahcelievler, Ankara 06490, Turkey

Tel.: 90 312 2127393

Fax: 90 312 2150835

E-mail: rektorluk@...

This work was presented at the IPTA 2007 Cancun, Mexico, 17-2.03.2007

AFP, alpha-fetoprotein; CT, computed tomography; HCC, hepatocellular carcinoma;

LDLT, living donor liver transplantation; LTs, liver transplants; OLT,

orthotopic liver transplantation; PELD, pediatric end-stage liver disease;

SIOPEL, SIOP group for epithelial liver tumors; TNM, tumor-node-metastasis;

TT-1, tyrosinemia type-1.

Sevmis S, Karakayali H, Özçay F, Canan O, Bilezikci B, Torgay A, Haberal M.

Liver transplantation for hepatocellular carcinoma in children.

Abstract

Abstract: We present our experience with living-donor liver transplantation in

the treatment of nine children with hepatocellular carcinoma. Between January

2001 and March 2007, we performed 81 liver transplantations in 79 children at

our center. Nine of the 79 children (11.3%; mean age, 9.7 ± 5.5 yr; age range,

12 months–16 yr; male-to-female ratio, 2:1) underwent an living-donor liver

transplantation because of hepatocellular carcinoma. Two of nine children

received right lobe grafts, three received left lateral segment grafts, and the

remaining four children received a left lobe graft. According to the TNM staging

system, two children had stage 1 carcinoma, three had stage 2, and four had

stage 4A1. The mean follow-up was 19.8 ± 10.6 months (range: 7–32 months). There

has been only one tumor recurrence, which occurred in the omentum 26 months

after liver transplantation. There was no evidence of recurrence or AFP

elevation in the other eight children. Both graft and patient survival rates are

100%. In conclusion, liver transplantation is a life-saving procedure for

children with chronic liver disease with accompanying hepatocellular carcinoma.

During follow-up of patients with chronic liver disease, serial AFP screening

and combined radiologic imaging studies should be mandatory.

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1399-3046.2007.00777.x

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January 7, 2008