Is Early Recurrence of Hepatitis C Associated With Biliary Anastomotic Stricture After Liver Transpl

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Transplantation. 2007 Dec 27;84(12):1631-1635.

Is Early Recurrence of Hepatitis C Associated With Biliary Anastomotic Stricture

After Liver Transplantation?

Fujita S, Fujikawa T, Mizuno S, AI, Kim RD, RJ, Firpi RJ, DR,

Hemming AW.

1 Division of Transplantation and Hepatobiliary Surgery, Department of Surgery,

University of Florida College of Medicine, Gainesville, FL. 2 Department of

Surgery, Kokura Memorial Hospital, Kitakyushu, Fukuoka, Japan. 3 Department of

Medicine, University of Florida College of Medicine, Gainesville, FL.

BACKGROUND.: While the main effect of hepatitis C virus (HCV) is hepatitis, HCV

is also known to cause a variety of systemic immunologic inflammatory

abnormalities. The effect of HCV infection on the biliary tract after liver

transplantation (LT) is not well understood. The aim of the current study is to

determine if recurrence of hepatitis C affects biliary complications after LT,

with special reference to late biliary anastomotic strictures (LBAS). METHODS.:

A total of 688 consecutive adult LT recipients with a choledochocholedochostomy

without T-tube placement between 1990 and 2005 were reviewed. Biliary

anastomotic stricture was confirmed by endoscopic retrograde

cholangiopancreatography. LBAS was defined as stricture that occurred 30 days or

more after LT. Early HCV recurrence was defined as recurrence within 6 months

after LT. RESULTS.: LBAS occurred in 55 patients (8% of total). Patients with

HCV infection had a higher occurrence of LBAS than non-HCV patients (11% vs. 5%,

P=0.0093). Among HCV patients, those with early HCV recurrence had an

exceedingly high rate of LBAS (16%). In multivariate analyses, early recurrence

of hepatitis C (P

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Transplantation. 2007 Dec 27;84(12):1631-1635.

Is Early Recurrence of Hepatitis C Associated With Biliary Anastomotic Stricture

After Liver Transplantation?

Fujita S, Fujikawa T, Mizuno S, AI, Kim RD, RJ, Firpi RJ, DR,

Hemming AW.

1 Division of Transplantation and Hepatobiliary Surgery, Department of Surgery,

University of Florida College of Medicine, Gainesville, FL. 2 Department of

Surgery, Kokura Memorial Hospital, Kitakyushu, Fukuoka, Japan. 3 Department of

Medicine, University of Florida College of Medicine, Gainesville, FL.

BACKGROUND.: While the main effect of hepatitis C virus (HCV) is hepatitis, HCV

is also known to cause a variety of systemic immunologic inflammatory

abnormalities. The effect of HCV infection on the biliary tract after liver

transplantation (LT) is not well understood. The aim of the current study is to

determine if recurrence of hepatitis C affects biliary complications after LT,

with special reference to late biliary anastomotic strictures (LBAS). METHODS.:

A total of 688 consecutive adult LT recipients with a choledochocholedochostomy

without T-tube placement between 1990 and 2005 were reviewed. Biliary

anastomotic stricture was confirmed by endoscopic retrograde

cholangiopancreatography. LBAS was defined as stricture that occurred 30 days or

more after LT. Early HCV recurrence was defined as recurrence within 6 months

after LT. RESULTS.: LBAS occurred in 55 patients (8% of total). Patients with

HCV infection had a higher occurrence of LBAS than non-HCV patients (11% vs. 5%,

P=0.0093). Among HCV patients, those with early HCV recurrence had an

exceedingly high rate of LBAS (16%). In multivariate analyses, early recurrence

of hepatitis C (P

_________________________________________________________________

Get the power of Windows + Web with the new Windows Live.

http://www.windowslive.com?ocid=TXT_TAGHM_Wave2_powerofwindows_012008

[Guest guest]

Transplantation. 2007 Dec 27;84(12):1631-1635.

Is Early Recurrence of Hepatitis C Associated With Biliary Anastomotic Stricture

After Liver Transplantation?

Fujita S, Fujikawa T, Mizuno S, AI, Kim RD, RJ, Firpi RJ, DR,

Hemming AW.

1 Division of Transplantation and Hepatobiliary Surgery, Department of Surgery,

University of Florida College of Medicine, Gainesville, FL. 2 Department of

Surgery, Kokura Memorial Hospital, Kitakyushu, Fukuoka, Japan. 3 Department of

Medicine, University of Florida College of Medicine, Gainesville, FL.

BACKGROUND.: While the main effect of hepatitis C virus (HCV) is hepatitis, HCV

is also known to cause a variety of systemic immunologic inflammatory

abnormalities. The effect of HCV infection on the biliary tract after liver

transplantation (LT) is not well understood. The aim of the current study is to

determine if recurrence of hepatitis C affects biliary complications after LT,

with special reference to late biliary anastomotic strictures (LBAS). METHODS.:

A total of 688 consecutive adult LT recipients with a choledochocholedochostomy

without T-tube placement between 1990 and 2005 were reviewed. Biliary

anastomotic stricture was confirmed by endoscopic retrograde

cholangiopancreatography. LBAS was defined as stricture that occurred 30 days or

more after LT. Early HCV recurrence was defined as recurrence within 6 months

after LT. RESULTS.: LBAS occurred in 55 patients (8% of total). Patients with

HCV infection had a higher occurrence of LBAS than non-HCV patients (11% vs. 5%,

P=0.0093). Among HCV patients, those with early HCV recurrence had an

exceedingly high rate of LBAS (16%). In multivariate analyses, early recurrence

of hepatitis C (P

_________________________________________________________________

Get the power of Windows + Web with the new Windows Live.

http://www.windowslive.com?ocid=TXT_TAGHM_Wave2_powerofwindows_012008

[Guest guest]

Transplantation. 2007 Dec 27;84(12):1631-1635.

Is Early Recurrence of Hepatitis C Associated With Biliary Anastomotic Stricture

After Liver Transplantation?

Fujita S, Fujikawa T, Mizuno S, AI, Kim RD, RJ, Firpi RJ, DR,

Hemming AW.

1 Division of Transplantation and Hepatobiliary Surgery, Department of Surgery,

University of Florida College of Medicine, Gainesville, FL. 2 Department of

Surgery, Kokura Memorial Hospital, Kitakyushu, Fukuoka, Japan. 3 Department of

Medicine, University of Florida College of Medicine, Gainesville, FL.

BACKGROUND.: While the main effect of hepatitis C virus (HCV) is hepatitis, HCV

is also known to cause a variety of systemic immunologic inflammatory

abnormalities. The effect of HCV infection on the biliary tract after liver

transplantation (LT) is not well understood. The aim of the current study is to

determine if recurrence of hepatitis C affects biliary complications after LT,

with special reference to late biliary anastomotic strictures (LBAS). METHODS.:

A total of 688 consecutive adult LT recipients with a choledochocholedochostomy

without T-tube placement between 1990 and 2005 were reviewed. Biliary

anastomotic stricture was confirmed by endoscopic retrograde

cholangiopancreatography. LBAS was defined as stricture that occurred 30 days or

more after LT. Early HCV recurrence was defined as recurrence within 6 months

after LT. RESULTS.: LBAS occurred in 55 patients (8% of total). Patients with

HCV infection had a higher occurrence of LBAS than non-HCV patients (11% vs. 5%,

P=0.0093). Among HCV patients, those with early HCV recurrence had an

exceedingly high rate of LBAS (16%). In multivariate analyses, early recurrence

of hepatitis C (P

_________________________________________________________________

Get the power of Windows + Web with the new Windows Live.

http://www.windowslive.com?ocid=TXT_TAGHM_Wave2_powerofwindows_012008