Hepatitis B virus-associated glomerular nephritis in East Asia: Progress and challenges

[Guest guest]

http://www.ejinme.com/article/PIIS0953620510002256/abstract?rss=yes

European Journal of Internal Medicine

Volume 22, Issue 2 , Pages 161-166, April 2011.

Hepatitis B virus-associated glomerular nephritis in East Asia: Progress and

challenges

Gaosi Xu, Tianlun Huang

Received 18 August 2010; received in revised form 18 October 2010; accepted 16

November 2010. published online 20 December 2010.

Abstract

Background

Hepatitis B virus-associated glomerular nephritis (HBV-GN) is the most common

secondary glomerulonephritis in East Asia. Part of the patients developed to

renal insufficiency within 10years, which cause a great burden for patients'

family and society.

Methods

We reviewed basic and clinical research work in China, Japan, Korea, and

Mongolia, eastern part of Asia. Comparisons between data from East Asia and

those from other regions were made.

Results

The genetic variations conferring susceptibility to HBV-GN and disease

progression as well as the pathogenic role in HBV-GN progression were

investigated. Clinical features of HBV-GN in East Asia were different from that

of other regions in the world. Clinical trials showed that treatment with

anti-viral agents was effective to promote the disease remission.

Conclusion

HBV-GN remains a great challenge to East Asian nephrologists. In-depth basic

studies and multi-centered clinical trials are needed in the future.

[Guest guest]

http://www.ejinme.com/article/PIIS0953620510002256/abstract?rss=yes

European Journal of Internal Medicine

Volume 22, Issue 2 , Pages 161-166, April 2011.

Hepatitis B virus-associated glomerular nephritis in East Asia: Progress and

challenges

Gaosi Xu, Tianlun Huang

Received 18 August 2010; received in revised form 18 October 2010; accepted 16

November 2010. published online 20 December 2010.

Abstract

Background

Hepatitis B virus-associated glomerular nephritis (HBV-GN) is the most common

secondary glomerulonephritis in East Asia. Part of the patients developed to

renal insufficiency within 10years, which cause a great burden for patients'

family and society.

Methods

We reviewed basic and clinical research work in China, Japan, Korea, and

Mongolia, eastern part of Asia. Comparisons between data from East Asia and

those from other regions were made.

Results

The genetic variations conferring susceptibility to HBV-GN and disease

progression as well as the pathogenic role in HBV-GN progression were

investigated. Clinical features of HBV-GN in East Asia were different from that

of other regions in the world. Clinical trials showed that treatment with

anti-viral agents was effective to promote the disease remission.

Conclusion

HBV-GN remains a great challenge to East Asian nephrologists. In-depth basic

studies and multi-centered clinical trials are needed in the future.

[Guest guest]

http://www.ejinme.com/article/PIIS0953620510002256/abstract?rss=yes

European Journal of Internal Medicine

Volume 22, Issue 2 , Pages 161-166, April 2011.

Hepatitis B virus-associated glomerular nephritis in East Asia: Progress and

challenges

Gaosi Xu, Tianlun Huang

Received 18 August 2010; received in revised form 18 October 2010; accepted 16

November 2010. published online 20 December 2010.

Abstract

Background

Hepatitis B virus-associated glomerular nephritis (HBV-GN) is the most common

secondary glomerulonephritis in East Asia. Part of the patients developed to

renal insufficiency within 10years, which cause a great burden for patients'

family and society.

Methods

We reviewed basic and clinical research work in China, Japan, Korea, and

Mongolia, eastern part of Asia. Comparisons between data from East Asia and

those from other regions were made.

Results

The genetic variations conferring susceptibility to HBV-GN and disease

progression as well as the pathogenic role in HBV-GN progression were

investigated. Clinical features of HBV-GN in East Asia were different from that

of other regions in the world. Clinical trials showed that treatment with

anti-viral agents was effective to promote the disease remission.

Conclusion

HBV-GN remains a great challenge to East Asian nephrologists. In-depth basic

studies and multi-centered clinical trials are needed in the future.

[Guest guest]

http://www.ejinme.com/article/PIIS0953620510002256/abstract?rss=yes

European Journal of Internal Medicine

Volume 22, Issue 2 , Pages 161-166, April 2011.

Hepatitis B virus-associated glomerular nephritis in East Asia: Progress and

challenges

Gaosi Xu, Tianlun Huang

Received 18 August 2010; received in revised form 18 October 2010; accepted 16

November 2010. published online 20 December 2010.

Abstract

Background

Hepatitis B virus-associated glomerular nephritis (HBV-GN) is the most common

secondary glomerulonephritis in East Asia. Part of the patients developed to

renal insufficiency within 10years, which cause a great burden for patients'

family and society.

Methods

We reviewed basic and clinical research work in China, Japan, Korea, and

Mongolia, eastern part of Asia. Comparisons between data from East Asia and

those from other regions were made.

Results

The genetic variations conferring susceptibility to HBV-GN and disease

progression as well as the pathogenic role in HBV-GN progression were

investigated. Clinical features of HBV-GN in East Asia were different from that

of other regions in the world. Clinical trials showed that treatment with

anti-viral agents was effective to promote the disease remission.

Conclusion

HBV-GN remains a great challenge to East Asian nephrologists. In-depth basic

studies and multi-centered clinical trials are needed in the future.