Trends in incidence of hepatocellular carcinoma after diagnosis of hepatitis B or C infection: a population-based cohort study, 1992-2007.

[Guest guest]

J Viral Hepat. 2011 Jul;18(7):e232-e241. doi: 10.1111/j.1365-2893.2011.01440.x.

Epub 2011 Feb 17.

Trends in incidence of hepatocellular carcinoma after diagnosis of hepatitis B

or C infection: a population-based cohort study, 1992-2007.

Thein HH, Walter SR, Gidding HF, Amin J, Law MG, J, Dore GJ.

Source

National Centre in HIV Epidemiology and Clinical Research, The University of New

South Wales, Sydney, NSW, Australia Dalla Lana School of Public Health,

University of Toronto, Toronto, ON, Canada Toronto Health Economics and

Technology Assessment Collaborative (THETA), Toronto, ON, Canada Storr Liver

Unit, Westmead Hospital and Westmead Millennium Institute, University of Sydney,

Sydney, NSW, Australia HIV/Immunology/Infectious Diseases Clinical Services

Unit, St 's Hospital, Sydney, NSW, Australia.

Abstract

Summary.  Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV)

infections are the major risk factors for hepatocellular carcinoma (HCC). We

examined trends in the incidence of HCC among a population-based cohort of

people infected with HBV or HCV. HBV and HCV cases notified to the New South

Wales Health Department between 1992 and 2007 were linked to the Central Cancer

Registry, Registry of Births, Deaths and Marriages, and National HIV/AIDS

Registries. Crude HCC incidence rates were estimated using person-time

methodology. Age-standardized incidence rates were calculated using the 2001

Australian population. Trends in incidence were examined using join point

regression models. Between 1992 and 2007, 1201 people had a linked HCC record:

556 of those with HBV; 592 with HCV; 45 with HBV/HCV co-infection; and 8 with

HIV co-infection. The overall age-standardized HCC incidence rates declined

non-significantly from 148.0 (95% confidence intervals (CI) 63.7, 287.4) per

100 000 population in 1995 to 101.2 (95% CI 67.3, 144.6) in 2007 among the HBV

monoinfected group and significantly from 151.8 (95% CI 62.4, 299.8) per

100 000 population to 75.3 (95% CI 50.8, 105.5) among the HCV monoinfected

group. However, incidence rates in the HCV monoinfected group progressively

increased from the period 1992-1997 to 2004-2007 when adjusted for age, sex, and

birth cohort, and the total number of cases per annum continued to increase.

Despite declines in the age-adjusted incidence rates of HCC over time, the

absolute number of cases increased likely due to the ageing cohort and an

increasing prevalence of both hepatitis B and C in Australia.

© 2011 Blackwell Publishing Ltd.

PMID: 21692938 [PubMed - as supplied by publisher]

[Guest guest]

J Viral Hepat. 2011 Jul;18(7):e232-e241. doi: 10.1111/j.1365-2893.2011.01440.x.

Epub 2011 Feb 17.

Trends in incidence of hepatocellular carcinoma after diagnosis of hepatitis B

or C infection: a population-based cohort study, 1992-2007.

Thein HH, Walter SR, Gidding HF, Amin J, Law MG, J, Dore GJ.

Source

National Centre in HIV Epidemiology and Clinical Research, The University of New

South Wales, Sydney, NSW, Australia Dalla Lana School of Public Health,

University of Toronto, Toronto, ON, Canada Toronto Health Economics and

Technology Assessment Collaborative (THETA), Toronto, ON, Canada Storr Liver

Unit, Westmead Hospital and Westmead Millennium Institute, University of Sydney,

Sydney, NSW, Australia HIV/Immunology/Infectious Diseases Clinical Services

Unit, St 's Hospital, Sydney, NSW, Australia.

Abstract

Summary.  Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV)

infections are the major risk factors for hepatocellular carcinoma (HCC). We

examined trends in the incidence of HCC among a population-based cohort of

people infected with HBV or HCV. HBV and HCV cases notified to the New South

Wales Health Department between 1992 and 2007 were linked to the Central Cancer

Registry, Registry of Births, Deaths and Marriages, and National HIV/AIDS

Registries. Crude HCC incidence rates were estimated using person-time

methodology. Age-standardized incidence rates were calculated using the 2001

Australian population. Trends in incidence were examined using join point

regression models. Between 1992 and 2007, 1201 people had a linked HCC record:

556 of those with HBV; 592 with HCV; 45 with HBV/HCV co-infection; and 8 with

HIV co-infection. The overall age-standardized HCC incidence rates declined

non-significantly from 148.0 (95% confidence intervals (CI) 63.7, 287.4) per

100 000 population in 1995 to 101.2 (95% CI 67.3, 144.6) in 2007 among the HBV

monoinfected group and significantly from 151.8 (95% CI 62.4, 299.8) per

100 000 population to 75.3 (95% CI 50.8, 105.5) among the HCV monoinfected

group. However, incidence rates in the HCV monoinfected group progressively

increased from the period 1992-1997 to 2004-2007 when adjusted for age, sex, and

birth cohort, and the total number of cases per annum continued to increase.

Despite declines in the age-adjusted incidence rates of HCC over time, the

absolute number of cases increased likely due to the ageing cohort and an

increasing prevalence of both hepatitis B and C in Australia.

© 2011 Blackwell Publishing Ltd.

PMID: 21692938 [PubMed - as supplied by publisher]

[Guest guest]

J Viral Hepat. 2011 Jul;18(7):e232-e241. doi: 10.1111/j.1365-2893.2011.01440.x.

Epub 2011 Feb 17.

Trends in incidence of hepatocellular carcinoma after diagnosis of hepatitis B

or C infection: a population-based cohort study, 1992-2007.

Thein HH, Walter SR, Gidding HF, Amin J, Law MG, J, Dore GJ.

Source

National Centre in HIV Epidemiology and Clinical Research, The University of New

South Wales, Sydney, NSW, Australia Dalla Lana School of Public Health,

University of Toronto, Toronto, ON, Canada Toronto Health Economics and

Technology Assessment Collaborative (THETA), Toronto, ON, Canada Storr Liver

Unit, Westmead Hospital and Westmead Millennium Institute, University of Sydney,

Sydney, NSW, Australia HIV/Immunology/Infectious Diseases Clinical Services

Unit, St 's Hospital, Sydney, NSW, Australia.

Abstract

Summary.  Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV)

infections are the major risk factors for hepatocellular carcinoma (HCC). We

examined trends in the incidence of HCC among a population-based cohort of

people infected with HBV or HCV. HBV and HCV cases notified to the New South

Wales Health Department between 1992 and 2007 were linked to the Central Cancer

Registry, Registry of Births, Deaths and Marriages, and National HIV/AIDS

Registries. Crude HCC incidence rates were estimated using person-time

methodology. Age-standardized incidence rates were calculated using the 2001

Australian population. Trends in incidence were examined using join point

regression models. Between 1992 and 2007, 1201 people had a linked HCC record:

556 of those with HBV; 592 with HCV; 45 with HBV/HCV co-infection; and 8 with

HIV co-infection. The overall age-standardized HCC incidence rates declined

non-significantly from 148.0 (95% confidence intervals (CI) 63.7, 287.4) per

100 000 population in 1995 to 101.2 (95% CI 67.3, 144.6) in 2007 among the HBV

monoinfected group and significantly from 151.8 (95% CI 62.4, 299.8) per

100 000 population to 75.3 (95% CI 50.8, 105.5) among the HCV monoinfected

group. However, incidence rates in the HCV monoinfected group progressively

increased from the period 1992-1997 to 2004-2007 when adjusted for age, sex, and

birth cohort, and the total number of cases per annum continued to increase.

Despite declines in the age-adjusted incidence rates of HCC over time, the

absolute number of cases increased likely due to the ageing cohort and an

increasing prevalence of both hepatitis B and C in Australia.

© 2011 Blackwell Publishing Ltd.

PMID: 21692938 [PubMed - as supplied by publisher]

[Guest guest]

J Viral Hepat. 2011 Jul;18(7):e232-e241. doi: 10.1111/j.1365-2893.2011.01440.x.

Epub 2011 Feb 17.

Trends in incidence of hepatocellular carcinoma after diagnosis of hepatitis B

or C infection: a population-based cohort study, 1992-2007.

Thein HH, Walter SR, Gidding HF, Amin J, Law MG, J, Dore GJ.

Source

National Centre in HIV Epidemiology and Clinical Research, The University of New

South Wales, Sydney, NSW, Australia Dalla Lana School of Public Health,

University of Toronto, Toronto, ON, Canada Toronto Health Economics and

Technology Assessment Collaborative (THETA), Toronto, ON, Canada Storr Liver

Unit, Westmead Hospital and Westmead Millennium Institute, University of Sydney,

Sydney, NSW, Australia HIV/Immunology/Infectious Diseases Clinical Services

Unit, St 's Hospital, Sydney, NSW, Australia.

Abstract

Summary.  Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV)

infections are the major risk factors for hepatocellular carcinoma (HCC). We

examined trends in the incidence of HCC among a population-based cohort of

people infected with HBV or HCV. HBV and HCV cases notified to the New South

Wales Health Department between 1992 and 2007 were linked to the Central Cancer

Registry, Registry of Births, Deaths and Marriages, and National HIV/AIDS

Registries. Crude HCC incidence rates were estimated using person-time

methodology. Age-standardized incidence rates were calculated using the 2001

Australian population. Trends in incidence were examined using join point

regression models. Between 1992 and 2007, 1201 people had a linked HCC record:

556 of those with HBV; 592 with HCV; 45 with HBV/HCV co-infection; and 8 with

HIV co-infection. The overall age-standardized HCC incidence rates declined

non-significantly from 148.0 (95% confidence intervals (CI) 63.7, 287.4) per

100 000 population in 1995 to 101.2 (95% CI 67.3, 144.6) in 2007 among the HBV

monoinfected group and significantly from 151.8 (95% CI 62.4, 299.8) per

100 000 population to 75.3 (95% CI 50.8, 105.5) among the HCV monoinfected

group. However, incidence rates in the HCV monoinfected group progressively

increased from the period 1992-1997 to 2004-2007 when adjusted for age, sex, and

birth cohort, and the total number of cases per annum continued to increase.

Despite declines in the age-adjusted incidence rates of HCC over time, the

absolute number of cases increased likely due to the ageing cohort and an

increasing prevalence of both hepatitis B and C in Australia.

© 2011 Blackwell Publishing Ltd.

PMID: 21692938 [PubMed - as supplied by publisher]